Gal-3 Protein Expression and Localization in Prostate Tumours

Detalhes bibliográficos
Autor(a) principal: Lima, Tânia
Data de Publicação: 2023
Outros Autores: Macedo-Silva, Catarina, Felizardo, Diana, Fraga, João, Carneiro, Isa, Jerónimo, Carmen, Henrique, Rui, Fardilha, Margarida, Vitorino, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/40040
Resumo: Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-related biological processes (e.g., morphogenesis of the prostate gland epithelium), we aimed to investigate this protein immunohistochemically in tumour and normal prostate tissues. Gal-3 protein expression was evaluated in 48 tumour prostate tissues, eight normal prostate tissues and 14 adjacent-normal prostate tissues. Decreased Gal-3 staining was detected in tumour tissues compared with normal tissues. Although Gal-3 staining was decreased in tumour tissues with GS 5-8 and pT2 and pT3 stages compared with normal prostate tissue, no correlation was found between Gal-3 expression and PCa progression. In the present study, the pattern of cellular localization differed between groups, as Gal-3 was predominantly excluded from the nucleus in tumour tissues. Furthermore, Gal-3 had no significant effect on survival and relapse in these PCa patients. This work confirms Gal-3 as a promising marker for PCa diagnosis.
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spelling Gal-3 Protein Expression and Localization in Prostate TumoursGal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-related biological processes (e.g., morphogenesis of the prostate gland epithelium), we aimed to investigate this protein immunohistochemically in tumour and normal prostate tissues. Gal-3 protein expression was evaluated in 48 tumour prostate tissues, eight normal prostate tissues and 14 adjacent-normal prostate tissues. Decreased Gal-3 staining was detected in tumour tissues compared with normal tissues. Although Gal-3 staining was decreased in tumour tissues with GS 5-8 and pT2 and pT3 stages compared with normal prostate tissue, no correlation was found between Gal-3 expression and PCa progression. In the present study, the pattern of cellular localization differed between groups, as Gal-3 was predominantly excluded from the nucleus in tumour tissues. Furthermore, Gal-3 had no significant effect on survival and relapse in these PCa patients. This work confirms Gal-3 as a promising marker for PCa diagnosis.MDPI2024-01-10T11:26:41Z2023-03-01T00:00:00Z2023-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/40040eng1718-772910.3390/curroncol30030206Lima, TâniaMacedo-Silva, CatarinaFelizardo, DianaFraga, JoãoCarneiro, IsaJerónimo, CarmenHenrique, RuiFardilha, MargaridaVitorino, Ruiinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:18:13Zoai:ria.ua.pt:10773/40040Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:10:04.550746Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gal-3 Protein Expression and Localization in Prostate Tumours
title Gal-3 Protein Expression and Localization in Prostate Tumours
spellingShingle Gal-3 Protein Expression and Localization in Prostate Tumours
Lima, Tânia
title_short Gal-3 Protein Expression and Localization in Prostate Tumours
title_full Gal-3 Protein Expression and Localization in Prostate Tumours
title_fullStr Gal-3 Protein Expression and Localization in Prostate Tumours
title_full_unstemmed Gal-3 Protein Expression and Localization in Prostate Tumours
title_sort Gal-3 Protein Expression and Localization in Prostate Tumours
author Lima, Tânia
author_facet Lima, Tânia
Macedo-Silva, Catarina
Felizardo, Diana
Fraga, João
Carneiro, Isa
Jerónimo, Carmen
Henrique, Rui
Fardilha, Margarida
Vitorino, Rui
author_role author
author2 Macedo-Silva, Catarina
Felizardo, Diana
Fraga, João
Carneiro, Isa
Jerónimo, Carmen
Henrique, Rui
Fardilha, Margarida
Vitorino, Rui
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Tânia
Macedo-Silva, Catarina
Felizardo, Diana
Fraga, João
Carneiro, Isa
Jerónimo, Carmen
Henrique, Rui
Fardilha, Margarida
Vitorino, Rui
description Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-related biological processes (e.g., morphogenesis of the prostate gland epithelium), we aimed to investigate this protein immunohistochemically in tumour and normal prostate tissues. Gal-3 protein expression was evaluated in 48 tumour prostate tissues, eight normal prostate tissues and 14 adjacent-normal prostate tissues. Decreased Gal-3 staining was detected in tumour tissues compared with normal tissues. Although Gal-3 staining was decreased in tumour tissues with GS 5-8 and pT2 and pT3 stages compared with normal prostate tissue, no correlation was found between Gal-3 expression and PCa progression. In the present study, the pattern of cellular localization differed between groups, as Gal-3 was predominantly excluded from the nucleus in tumour tissues. Furthermore, Gal-3 had no significant effect on survival and relapse in these PCa patients. This work confirms Gal-3 as a promising marker for PCa diagnosis.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-01T00:00:00Z
2023-03
2024-01-10T11:26:41Z
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10.3390/curroncol30030206
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