Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers

Detalhes bibliográficos
Autor(a) principal: F. Fernández, Sandra
Data de Publicação: 2023
Outros Autores: Poteser, Michael, Govarts, Eva, Pardo, Olga, Coscollà, Clara, Schettgen, Thomas, Vogel, Nina, Weber, Till, Murawski, Aline, Kolossa-Gehring, Marike, Rüther, Maria, Schmidt, Phillipp, Namorado, Sónia, Van Nieuwenhuyse, An, Appenzeller, Brice, Ólafsdóttir, Kristín, Halldorsson, Thorhallur I., Haug, Line S., Thomsen, Cathrine, Barbone, Fabio, Mariuz, Marika, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Göen, Thomas, Nübler, Stefanie, Schäfer, Moritz, Zarrabi, Karin H.A., Sepai, Ovnair, Martin, Laura Rodriguez, Schoeters, Greet, Gilles, Liese, Leander, Karin, Moshammer, Hanns, Akesson, Agneta, Laguzzi, Federica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/167128
Resumo: The original version of this Article contained an error in the name of the author Federica Laguzzi, which was incorrectly given as Laguzzi Federica. https://doi.org/10.1038/s41598-024-52775-0 Funding Information: Open access funding provided by Karolinska Institute. This work was supported by the European Union Horizon-2020 Research and Innovation Programme under Grant Agreement No. 733032 (HBM4EU project). The funding of the German data by the German Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection is gratefully acknowledged. The Norwegian Institute of Public Health (NIPH) has contributed to funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research Projects (275903 and 268465). Funding Information: The authors thank all the partners of the HBM4EU project. Fernández S.F. acknowledges the CIBEFP/2021/51 funding provided by the Valencian Government (Spain) and the European Social Fund. We also thank Frumento P and Discacciati A. for their statistical support. Publisher Copyright: © 2023, The Author(s).
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spelling Determinants of exposure to acrylamide in European children and adults based on urinary biomarkersresults from the “European Human Biomonitoring Initiative” HBM4EU participating studiesGeneralThe original version of this Article contained an error in the name of the author Federica Laguzzi, which was incorrectly given as Laguzzi Federica. https://doi.org/10.1038/s41598-024-52775-0 Funding Information: Open access funding provided by Karolinska Institute. This work was supported by the European Union Horizon-2020 Research and Innovation Programme under Grant Agreement No. 733032 (HBM4EU project). The funding of the German data by the German Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection is gratefully acknowledged. The Norwegian Institute of Public Health (NIPH) has contributed to funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research Projects (275903 and 268465). Funding Information: The authors thank all the partners of the HBM4EU project. Fernández S.F. acknowledges the CIBEFP/2021/51 funding provided by the Valencian Government (Spain) and the European Social Fund. We also thank Frumento P and Discacciati A. for their statistical support. Publisher Copyright: © 2023, The Author(s).Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014–2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3–18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20–45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = − 9.1 µg/g creatinine, 95% CI − 15.8, − 2.4; GAMA: β = − 3.4 µg/g creatinine, 95% CI − 4.7, − 2.2), living in rural areas (AAMA:β = − 4.7 µg/g creatinine, 95% CI − 8.6, − 0.8; GAMA:β = − 1.1 µg/g creatinine, 95% CI − 1.9, − 0.4) and increasing age (AAMA:β = − 1.9 µg/g creatinine, 95% CI − 2.4, − 1.4; GAMA:β = − 0.7 µg/g creatinine, 95% CI − 0.8, − 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries.Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNF. Fernández, SandraPoteser, MichaelGovarts, EvaPardo, OlgaCoscollà, ClaraSchettgen, ThomasVogel, NinaWeber, TillMurawski, AlineKolossa-Gehring, MarikeRüther, MariaSchmidt, PhillippNamorado, SóniaVan Nieuwenhuyse, AnAppenzeller, BriceÓlafsdóttir, KristínHalldorsson, Thorhallur I.Haug, Line S.Thomsen, CathrineBarbone, FabioMariuz, MarikaRosolen, ValentinaRambaud, LoïcRiou, MargauxGöen, ThomasNübler, StefanieSchäfer, MoritzZarrabi, Karin H.A.Sepai, OvnairMartin, Laura RodriguezSchoeters, GreetGilles, LieseLeander, KarinMoshammer, HannsAkesson, AgnetaLaguzzi, Federica2024-05-08T00:13:56Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/167128eng2045-2322PURE: 84853539https://doi.org/10.1038/s41598-023-48738-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-06-10T01:48:30Zoai:run.unl.pt:10362/167128Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-06-10T01:48:30Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
results from the “European Human Biomonitoring Initiative” HBM4EU participating studies
title Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
spellingShingle Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
F. Fernández, Sandra
General
title_short Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
title_full Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
title_fullStr Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
title_full_unstemmed Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
title_sort Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers
author F. Fernández, Sandra
author_facet F. Fernández, Sandra
Poteser, Michael
Govarts, Eva
Pardo, Olga
Coscollà, Clara
Schettgen, Thomas
Vogel, Nina
Weber, Till
Murawski, Aline
Kolossa-Gehring, Marike
Rüther, Maria
Schmidt, Phillipp
Namorado, Sónia
Van Nieuwenhuyse, An
Appenzeller, Brice
Ólafsdóttir, Kristín
Halldorsson, Thorhallur I.
Haug, Line S.
Thomsen, Cathrine
Barbone, Fabio
Mariuz, Marika
Rosolen, Valentina
Rambaud, Loïc
Riou, Margaux
Göen, Thomas
Nübler, Stefanie
Schäfer, Moritz
Zarrabi, Karin H.A.
Sepai, Ovnair
Martin, Laura Rodriguez
Schoeters, Greet
Gilles, Liese
Leander, Karin
Moshammer, Hanns
Akesson, Agneta
Laguzzi, Federica
author_role author
author2 Poteser, Michael
Govarts, Eva
Pardo, Olga
Coscollà, Clara
Schettgen, Thomas
Vogel, Nina
Weber, Till
Murawski, Aline
Kolossa-Gehring, Marike
Rüther, Maria
Schmidt, Phillipp
Namorado, Sónia
Van Nieuwenhuyse, An
Appenzeller, Brice
Ólafsdóttir, Kristín
Halldorsson, Thorhallur I.
Haug, Line S.
Thomsen, Cathrine
Barbone, Fabio
Mariuz, Marika
Rosolen, Valentina
Rambaud, Loïc
Riou, Margaux
Göen, Thomas
Nübler, Stefanie
Schäfer, Moritz
Zarrabi, Karin H.A.
Sepai, Ovnair
Martin, Laura Rodriguez
Schoeters, Greet
Gilles, Liese
Leander, Karin
Moshammer, Hanns
Akesson, Agneta
Laguzzi, Federica
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv F. Fernández, Sandra
Poteser, Michael
Govarts, Eva
Pardo, Olga
Coscollà, Clara
Schettgen, Thomas
Vogel, Nina
Weber, Till
Murawski, Aline
Kolossa-Gehring, Marike
Rüther, Maria
Schmidt, Phillipp
Namorado, Sónia
Van Nieuwenhuyse, An
Appenzeller, Brice
Ólafsdóttir, Kristín
Halldorsson, Thorhallur I.
Haug, Line S.
Thomsen, Cathrine
Barbone, Fabio
Mariuz, Marika
Rosolen, Valentina
Rambaud, Loïc
Riou, Margaux
Göen, Thomas
Nübler, Stefanie
Schäfer, Moritz
Zarrabi, Karin H.A.
Sepai, Ovnair
Martin, Laura Rodriguez
Schoeters, Greet
Gilles, Liese
Leander, Karin
Moshammer, Hanns
Akesson, Agneta
Laguzzi, Federica
dc.subject.por.fl_str_mv General
topic General
description The original version of this Article contained an error in the name of the author Federica Laguzzi, which was incorrectly given as Laguzzi Federica. https://doi.org/10.1038/s41598-024-52775-0 Funding Information: Open access funding provided by Karolinska Institute. This work was supported by the European Union Horizon-2020 Research and Innovation Programme under Grant Agreement No. 733032 (HBM4EU project). The funding of the German data by the German Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection is gratefully acknowledged. The Norwegian Institute of Public Health (NIPH) has contributed to funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research Projects (275903 and 268465). Funding Information: The authors thank all the partners of the HBM4EU project. Fernández S.F. acknowledges the CIBEFP/2021/51 funding provided by the Valencian Government (Spain) and the European Social Fund. We also thank Frumento P and Discacciati A. for their statistical support. Publisher Copyright: © 2023, The Author(s).
publishDate 2023
dc.date.none.fl_str_mv 2023-12
2023-12-01T00:00:00Z
2024-05-08T00:13:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/167128
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dc.language.iso.fl_str_mv eng
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PURE: 84853539
https://doi.org/10.1038/s41598-023-48738-6
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