Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes

Detalhes bibliográficos
Autor(a) principal: Khrystyna, Kucheryava
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/70421
Resumo: "Therapeutic antibodies and antibody derivatives comprise the majority of today’s biotherapeutics. Their stability, resistance to stress conditions and high solubility have allowed the successful development and commercialization of over 40 antibody-based drugs. These antibodies are, in their majority, based on the IgG1 isotype, and are capable of evoking effector functions as ADCC and CDC. However there has been an increased interest in producing other antibody formats like IgG2, IgG4S228P or aglycosylated IgG1s when effector functions are unnecessary or unwanted.(...)"
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spelling Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other IsotypesAnticorpo monoclonalIsótipo de IgGCaracterização comparativaEstabilidade de anticorpoAgregação proteicaFragmentação"Therapeutic antibodies and antibody derivatives comprise the majority of today’s biotherapeutics. Their stability, resistance to stress conditions and high solubility have allowed the successful development and commercialization of over 40 antibody-based drugs. These antibodies are, in their majority, based on the IgG1 isotype, and are capable of evoking effector functions as ADCC and CDC. However there has been an increased interest in producing other antibody formats like IgG2, IgG4S228P or aglycosylated IgG1s when effector functions are unnecessary or unwanted.(...)"Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de LisboaRUNKhrystyna, Kucheryava2019-05-22T15:43:07Z2016-112016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/70421TID:202247600engmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:33:22Zoai:run.unl.pt:10362/70421Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:35:05.977586Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
title Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
spellingShingle Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
Khrystyna, Kucheryava
Anticorpo monoclonal
Isótipo de IgG
Caracterização comparativa
Estabilidade de anticorpo
Agregação proteica
Fragmentação
title_short Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
title_full Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
title_fullStr Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
title_full_unstemmed Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
title_sort Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
author Khrystyna, Kucheryava
author_facet Khrystyna, Kucheryava
author_role author
dc.contributor.none.fl_str_mv RUN
dc.contributor.author.fl_str_mv Khrystyna, Kucheryava
dc.subject.por.fl_str_mv Anticorpo monoclonal
Isótipo de IgG
Caracterização comparativa
Estabilidade de anticorpo
Agregação proteica
Fragmentação
topic Anticorpo monoclonal
Isótipo de IgG
Caracterização comparativa
Estabilidade de anticorpo
Agregação proteica
Fragmentação
description "Therapeutic antibodies and antibody derivatives comprise the majority of today’s biotherapeutics. Their stability, resistance to stress conditions and high solubility have allowed the successful development and commercialization of over 40 antibody-based drugs. These antibodies are, in their majority, based on the IgG1 isotype, and are capable of evoking effector functions as ADCC and CDC. However there has been an increased interest in producing other antibody formats like IgG2, IgG4S228P or aglycosylated IgG1s when effector functions are unnecessary or unwanted.(...)"
publishDate 2016
dc.date.none.fl_str_mv 2016-11
2016-11-01T00:00:00Z
2019-05-22T15:43:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/70421
TID:202247600
url http://hdl.handle.net/10362/70421
identifier_str_mv TID:202247600
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa
publisher.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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