The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity

Detalhes bibliográficos
Autor(a) principal: Salústio, Paulo
Data de Publicação: 2008
Outros Autores: Feio, Gabriel, Figueirinhas, João, Pinto, João, Marques, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/3805
Resumo: NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17.
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spelling The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavityIbuprofenIndomethacinCyclodextrinFreeze-dryingSpray-dryingPhysical mixtureKneadingNMRX-rayOptical microscopyFT-IR spectroscopyUV spectroscopyDSCNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17.The work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by bcyclodextrin (bCD), and the effect of water in such a process, and makes a comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug, bCD, and inclusion of either IB or IN in aqueous solutions of bCD. In the latter method water was removed by air stream, spray-drying and freeze-drying. To prove the formation of complexes in final products, optical microscopy, UV spectroscopy, IR spectroscopy, DSC, X-ray and NMR were considered. Each powder was added to an acidic solution (pH = 2) to quantify the concentration of the drug inside bCD cavity. Other media (pH = 5 and 7) were used to prove the existence of drug not complexed in each powder, as the drugs solubility increases with the pH. It was observed that complexation occurred in all powders, and that the fraction of drug inside the bCD did not depend neither on the method of complexation nor on the processes of drying considered.ElsevierRepositório da Universidade de LisboaSalústio, PauloFeio, GabrielFigueirinhas, JoãoPinto, JoãoMarques, Helena2011-07-22T12:26:25Z2008-10-172008-10-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/3805engEur J Pharm Biopharm. 2009 Feb; 71(2):377-3860939-6411info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:44:09Zoai:repositorio.ul.pt:10451/3805Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:29:28.762468Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
title The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
spellingShingle The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
Salústio, Paulo
Ibuprofen
Indomethacin
Cyclodextrin
Freeze-drying
Spray-drying
Physical mixture
Kneading
NMR
X-ray
Optical microscopy
FT-IR spectroscopy
UV spectroscopy
DSC
title_short The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
title_full The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
title_fullStr The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
title_full_unstemmed The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
title_sort The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
author Salústio, Paulo
author_facet Salústio, Paulo
Feio, Gabriel
Figueirinhas, João
Pinto, João
Marques, Helena
author_role author
author2 Feio, Gabriel
Figueirinhas, João
Pinto, João
Marques, Helena
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Salústio, Paulo
Feio, Gabriel
Figueirinhas, João
Pinto, João
Marques, Helena
dc.subject.por.fl_str_mv Ibuprofen
Indomethacin
Cyclodextrin
Freeze-drying
Spray-drying
Physical mixture
Kneading
NMR
X-ray
Optical microscopy
FT-IR spectroscopy
UV spectroscopy
DSC
topic Ibuprofen
Indomethacin
Cyclodextrin
Freeze-drying
Spray-drying
Physical mixture
Kneading
NMR
X-ray
Optical microscopy
FT-IR spectroscopy
UV spectroscopy
DSC
description NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17.
publishDate 2008
dc.date.none.fl_str_mv 2008-10-17
2008-10-17T00:00:00Z
2011-07-22T12:26:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/3805
url http://hdl.handle.net/10451/3805
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Pharm Biopharm. 2009 Feb; 71(2):377-386
0939-6411
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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