The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/3805 |
Resumo: | NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17. |
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The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavityIbuprofenIndomethacinCyclodextrinFreeze-dryingSpray-dryingPhysical mixtureKneadingNMRX-rayOptical microscopyFT-IR spectroscopyUV spectroscopyDSCNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17.The work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by bcyclodextrin (bCD), and the effect of water in such a process, and makes a comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug, bCD, and inclusion of either IB or IN in aqueous solutions of bCD. In the latter method water was removed by air stream, spray-drying and freeze-drying. To prove the formation of complexes in final products, optical microscopy, UV spectroscopy, IR spectroscopy, DSC, X-ray and NMR were considered. Each powder was added to an acidic solution (pH = 2) to quantify the concentration of the drug inside bCD cavity. Other media (pH = 5 and 7) were used to prove the existence of drug not complexed in each powder, as the drugs solubility increases with the pH. It was observed that complexation occurred in all powders, and that the fraction of drug inside the bCD did not depend neither on the method of complexation nor on the processes of drying considered.ElsevierRepositório da Universidade de LisboaSalústio, PauloFeio, GabrielFigueirinhas, JoãoPinto, JoãoMarques, Helena2011-07-22T12:26:25Z2008-10-172008-10-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/3805engEur J Pharm Biopharm. 2009 Feb; 71(2):377-3860939-6411info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:44:09Zoai:repositorio.ul.pt:10451/3805Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:29:28.762468Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
title |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
spellingShingle |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity Salústio, Paulo Ibuprofen Indomethacin Cyclodextrin Freeze-drying Spray-drying Physical mixture Kneading NMR X-ray Optical microscopy FT-IR spectroscopy UV spectroscopy DSC |
title_short |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
title_full |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
title_fullStr |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
title_full_unstemmed |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
title_sort |
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity |
author |
Salústio, Paulo |
author_facet |
Salústio, Paulo Feio, Gabriel Figueirinhas, João Pinto, João Marques, Helena |
author_role |
author |
author2 |
Feio, Gabriel Figueirinhas, João Pinto, João Marques, Helena |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Salústio, Paulo Feio, Gabriel Figueirinhas, João Pinto, João Marques, Helena |
dc.subject.por.fl_str_mv |
Ibuprofen Indomethacin Cyclodextrin Freeze-drying Spray-drying Physical mixture Kneading NMR X-ray Optical microscopy FT-IR spectroscopy UV spectroscopy DSC |
topic |
Ibuprofen Indomethacin Cyclodextrin Freeze-drying Spray-drying Physical mixture Kneading NMR X-ray Optical microscopy FT-IR spectroscopy UV spectroscopy DSC |
description |
NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-10-17 2008-10-17T00:00:00Z 2011-07-22T12:26:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/3805 |
url |
http://hdl.handle.net/10451/3805 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Eur J Pharm Biopharm. 2009 Feb; 71(2):377-386 0939-6411 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134179810607104 |