Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine

Detalhes bibliográficos
Autor(a) principal: Martins, Ivone M.
Data de Publicação: 2016
Outros Autores: Reis, R. L., Azevedo, Helena S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/43247
Resumo: The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).
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spelling Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicineRegenerative MedicineBiomaterialsPhage DisplayScience & TechnologyThe Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in-vitro and in-vivo approaches that leverage on the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous system. Phage display has been successfully employed to identify peptide ligands for a wide variety of targets, ranging from relatively small molecules (enzymes, cell receptors) to inorganic, organic, and biological (tissues) materials. Over the last two decades, phage display technology has advanced tremendously and has become a powerful tool in the most varied fields of research, including biotechnology, materials science, cell biology, pharmacology, and diagnostics. The growing interest in and success of phage display libraries is largely due its incredible versatility and practical use. This review discusses the potential of phage display technology in biomaterials engineering for applications in regenerative medicine.This work was supported by national funds through the Portuguese Foundation for Science and Technology under the scope of the project PTDC/EBB-BIO/114523/2009 and by the European Regional Development Fund (ERDF) through the Operational Competitiveness Programme “COMPETE” (FCOMP-01-0124-FEDER-014758). The authors are also thankful for the financial support of the Portuguese Foundation for Science and Technology under the strategic funding of UID/ BIO/04469/2013 unit and RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and the European Union under the Marie Curie Career Integration Grant SuprHApolymers (PCIG14-GA-2013-631871). We thank L. Kluskens, from the Center of Biological Engineering at the University of Minho (Portugal) for his expert opinion on phage display and valuable comments during the reading of the manuscript. We are also very grateful to A. Mata from the School of Engineering & Materials Science at Queen Mary University of London for his insightful comments and suggestions on the manuscript.American Chemical SocietyUniversidade do MinhoMartins, Ivone M.Reis, R. L.Azevedo, Helena S.2016-09-232016-09-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/43247engMartins, I.; Reis, Rui L.; Azevedo, Helena S., Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine. ACS Chemical Biology, 11(11), 2962-2980, 20161554-89291554-893710.1021/acschembio.5b0071727661443http://pubs.acs.org/journal/acbcctinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:00:51Zoai:repositorium.sdum.uminho.pt:1822/43247Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:50:44.296019Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
title Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
spellingShingle Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
Martins, Ivone M.
Regenerative Medicine
Biomaterials
Phage Display
Science & Technology
title_short Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
title_full Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
title_fullStr Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
title_full_unstemmed Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
title_sort Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine
author Martins, Ivone M.
author_facet Martins, Ivone M.
Reis, R. L.
Azevedo, Helena S.
author_role author
author2 Reis, R. L.
Azevedo, Helena S.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martins, Ivone M.
Reis, R. L.
Azevedo, Helena S.
dc.subject.por.fl_str_mv Regenerative Medicine
Biomaterials
Phage Display
Science & Technology
topic Regenerative Medicine
Biomaterials
Phage Display
Science & Technology
description The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).
publishDate 2016
dc.date.none.fl_str_mv 2016-09-23
2016-09-23T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/43247
url http://hdl.handle.net/1822/43247
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, I.; Reis, Rui L.; Azevedo, Helena S., Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine. ACS Chemical Biology, 11(11), 2962-2980, 2016
1554-8929
1554-8937
10.1021/acschembio.5b00717
27661443
http://pubs.acs.org/journal/acbcct
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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