Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/46278 |
Resumo: | Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia. |
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Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancerMagnetic nanoparticlesDrug deliveryMagnetoliposomesNew antitumor compoundsIron oxide nanoparticlesAqueous magnetoliposomesSolid magnetoliposomesAntitumor drugDual cancer therapyCiências Médicas::Biotecnologia MédicaCiências Naturais::Ciências FísicasEngenharia e Tecnologia::NanotecnologiaScience & TechnologyIron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013) and of CQUM (UID/QUI/00686/2013). FCT, POPH-QREN and FSE are acknowledged for the PhD grants of A.R.O. Rodrigues (SFRH/BD/90949/2012) and V.A. Machado (SFRH/BD/77373/2011) and for financial support to MAP-Fis Joint Doctoral Programme.info:eu-repo/semantics/publishedVersionElsevier 1Universidade do MinhoRodrigues, Ana Rita OliveiraMendes, Pedro M. F.Silva, Pedro M. L.Machado, Vera Alexandra PereiraAlmeida, B. G.Araújo, João P.Queiroz, Maria João R. P.Castanheira, Elisabete M. S.Coutinho, Paulo J. G.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/1822/46278engRodrigues, A. R. O., Mendes, P. M. F., Silva, P. M. L., Machado, V. A., Almeida, B. G., Araújo, J. P., … Coutinho, P. J. G. (2017, October). Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer. Colloids and Surfaces B: Biointerfaces. Elsevier BV. http://doi.org/10.1016/j.colsurfb.2017.07.0150927-776510.1016/j.colsurfb.2017.07.01528732311http://www.sciencedirect.com/science/article/pii/S0927776517304277info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-07-13T02:04:26Zoai:repositorium.sdum.uminho.pt:1822/46278Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-07-13T02:04:26Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
title |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
spellingShingle |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer Rodrigues, Ana Rita Oliveira Magnetic nanoparticles Drug delivery Magnetoliposomes New antitumor compounds Iron oxide nanoparticles Aqueous magnetoliposomes Solid magnetoliposomes Antitumor drug Dual cancer therapy Ciências Médicas::Biotecnologia Médica Ciências Naturais::Ciências Físicas Engenharia e Tecnologia::Nanotecnologia Science & Technology |
title_short |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
title_full |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
title_fullStr |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
title_full_unstemmed |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
title_sort |
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer |
author |
Rodrigues, Ana Rita Oliveira |
author_facet |
Rodrigues, Ana Rita Oliveira Mendes, Pedro M. F. Silva, Pedro M. L. Machado, Vera Alexandra Pereira Almeida, B. G. Araújo, João P. Queiroz, Maria João R. P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
author_role |
author |
author2 |
Mendes, Pedro M. F. Silva, Pedro M. L. Machado, Vera Alexandra Pereira Almeida, B. G. Araújo, João P. Queiroz, Maria João R. P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rodrigues, Ana Rita Oliveira Mendes, Pedro M. F. Silva, Pedro M. L. Machado, Vera Alexandra Pereira Almeida, B. G. Araújo, João P. Queiroz, Maria João R. P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
dc.subject.por.fl_str_mv |
Magnetic nanoparticles Drug delivery Magnetoliposomes New antitumor compounds Iron oxide nanoparticles Aqueous magnetoliposomes Solid magnetoliposomes Antitumor drug Dual cancer therapy Ciências Médicas::Biotecnologia Médica Ciências Naturais::Ciências Físicas Engenharia e Tecnologia::Nanotecnologia Science & Technology |
topic |
Magnetic nanoparticles Drug delivery Magnetoliposomes New antitumor compounds Iron oxide nanoparticles Aqueous magnetoliposomes Solid magnetoliposomes Antitumor drug Dual cancer therapy Ciências Médicas::Biotecnologia Médica Ciências Naturais::Ciências Físicas Engenharia e Tecnologia::Nanotecnologia Science & Technology |
description |
Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/46278 |
url |
https://hdl.handle.net/1822/46278 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rodrigues, A. R. O., Mendes, P. M. F., Silva, P. M. L., Machado, V. A., Almeida, B. G., Araújo, J. P., … Coutinho, P. J. G. (2017, October). Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer. Colloids and Surfaces B: Biointerfaces. Elsevier BV. http://doi.org/10.1016/j.colsurfb.2017.07.015 0927-7765 10.1016/j.colsurfb.2017.07.015 28732311 http://www.sciencedirect.com/science/article/pii/S0927776517304277 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier 1 |
publisher.none.fl_str_mv |
Elsevier 1 |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817544902037209088 |