Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Ana Rita Oliveira
Data de Publicação: 2017
Outros Autores: Mendes, Pedro M. F., Silva, Pedro M. L., Machado, Vera Alexandra Pereira, Almeida, B. G., Araújo, João P., Queiroz, Maria João R. P., Castanheira, Elisabete M. S., Coutinho, Paulo J. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/46278
Resumo: Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
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spelling Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancerMagnetic nanoparticlesDrug deliveryMagnetoliposomesNew antitumor compoundsIron oxide nanoparticlesAqueous magnetoliposomesSolid magnetoliposomesAntitumor drugDual cancer therapyCiências Médicas::Biotecnologia MédicaCiências Naturais::Ciências FísicasEngenharia e Tecnologia::NanotecnologiaScience & TechnologyIron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013) and of CQUM (UID/QUI/00686/2013). FCT, POPH-QREN and FSE are acknowledged for the PhD grants of A.R.O. Rodrigues (SFRH/BD/90949/2012) and V.A. Machado (SFRH/BD/77373/2011) and for financial support to MAP-Fis Joint Doctoral Programme.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoRodrigues, Ana Rita OliveiraMendes, Pedro M. F.Silva, Pedro M. L.Machado, Vera Alexandra PereiraAlmeida, B. G.Araújo, João P.Queiroz, Maria João R. P.Castanheira, Elisabete M. S.Coutinho, Paulo J. G.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/1822/46278engRodrigues, A. R. O., Mendes, P. M. F., Silva, P. M. L., Machado, V. A., Almeida, B. G., Araújo, J. P., … Coutinho, P. J. G. (2017, October). Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer. Colloids and Surfaces B: Biointerfaces. Elsevier BV. http://doi.org/10.1016/j.colsurfb.2017.07.0150927-776510.1016/j.colsurfb.2017.07.01528732311http://www.sciencedirect.com/science/article/pii/S0927776517304277info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:14Zoai:repositorium.sdum.uminho.pt:1822/46278Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:25:22.200988Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
title Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
spellingShingle Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
Rodrigues, Ana Rita Oliveira
Magnetic nanoparticles
Drug delivery
Magnetoliposomes
New antitumor compounds
Iron oxide nanoparticles
Aqueous magnetoliposomes
Solid magnetoliposomes
Antitumor drug
Dual cancer therapy
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
title_short Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
title_full Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
title_fullStr Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
title_full_unstemmed Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
title_sort Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
author Rodrigues, Ana Rita Oliveira
author_facet Rodrigues, Ana Rita Oliveira
Mendes, Pedro M. F.
Silva, Pedro M. L.
Machado, Vera Alexandra Pereira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
author_role author
author2 Mendes, Pedro M. F.
Silva, Pedro M. L.
Machado, Vera Alexandra Pereira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Ana Rita Oliveira
Mendes, Pedro M. F.
Silva, Pedro M. L.
Machado, Vera Alexandra Pereira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
dc.subject.por.fl_str_mv Magnetic nanoparticles
Drug delivery
Magnetoliposomes
New antitumor compounds
Iron oxide nanoparticles
Aqueous magnetoliposomes
Solid magnetoliposomes
Antitumor drug
Dual cancer therapy
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
topic Magnetic nanoparticles
Drug delivery
Magnetoliposomes
New antitumor compounds
Iron oxide nanoparticles
Aqueous magnetoliposomes
Solid magnetoliposomes
Antitumor drug
Dual cancer therapy
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
description Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/46278
url https://hdl.handle.net/1822/46278
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, A. R. O., Mendes, P. M. F., Silva, P. M. L., Machado, V. A., Almeida, B. G., Araújo, J. P., … Coutinho, P. J. G. (2017, October). Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer. Colloids and Surfaces B: Biointerfaces. Elsevier BV. http://doi.org/10.1016/j.colsurfb.2017.07.015
0927-7765
10.1016/j.colsurfb.2017.07.015
28732311
http://www.sciencedirect.com/science/article/pii/S0927776517304277
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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