Neopterin in tuberculous and neoplastic pleural fluids

Detalhes bibliográficos
Autor(a) principal: Fontes Baganha, Manuel
Data de Publicação: 1992
Outros Autores: Mota-Pinto, Anabela, Pêgo, Maria Alice, Marques, Maria Alcide, Santos-Rosa, Manuel, Robalo Cordeiro, António José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/25400
https://doi.org/10.1007/BF00174318
Resumo: Neopterin is derived from guanosine-triphosphate, produced by stimulated macrophages under the influence of gamma interferon of lymphocyte origin. It has been suggested as an excellent marker for activation of the monocyte/macrophage axis in some clinical situations. We evaluated its concentration in the pleural effusions of 25 individuals (10 tuberculous and 15 neoplastic) as well as in the blood of 22 of them (8 tuberculous and 14 neoplastic), comparing these levels with those of a control group in 99 normal individuals. The concentration of neopterin was determined by radioimmunologic assay. This showed a significant increase (p less than 0.001) of neopterin levels in the tuberculous pleural fluid, compared to the neoplastic group (42 +/- 23/17 +/- 9 nmol/L). In the blood, values were nearly identical to the pleural fluid (41.3 +/- 25/15.8 +/- 6.9 nmol/L), although with significant differences between them and in relation to the control group (p less than 0.001), which had a normal serum value (5.11 +/- 1.92 nmol/L). We emphasize the influence of the neopterin levels in the pleural fluid on the diagnosis of causes of pleurisy and its importance as a marker of immunologic cellular activity.
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spelling Neopterin in tuberculous and neoplastic pleural fluidsNeopterinaNeopterin is derived from guanosine-triphosphate, produced by stimulated macrophages under the influence of gamma interferon of lymphocyte origin. It has been suggested as an excellent marker for activation of the monocyte/macrophage axis in some clinical situations. We evaluated its concentration in the pleural effusions of 25 individuals (10 tuberculous and 15 neoplastic) as well as in the blood of 22 of them (8 tuberculous and 14 neoplastic), comparing these levels with those of a control group in 99 normal individuals. The concentration of neopterin was determined by radioimmunologic assay. This showed a significant increase (p less than 0.001) of neopterin levels in the tuberculous pleural fluid, compared to the neoplastic group (42 +/- 23/17 +/- 9 nmol/L). In the blood, values were nearly identical to the pleural fluid (41.3 +/- 25/15.8 +/- 6.9 nmol/L), although with significant differences between them and in relation to the control group (p less than 0.001), which had a normal serum value (5.11 +/- 1.92 nmol/L). We emphasize the influence of the neopterin levels in the pleural fluid on the diagnosis of causes of pleurisy and its importance as a marker of immunologic cellular activity.1992info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/25400http://hdl.handle.net/10316/25400https://doi.org/10.1007/BF00174318engFontes Baganha, ManuelMota-Pinto, AnabelaPêgo, Maria AliceMarques, Maria AlcideSantos-Rosa, ManuelRobalo Cordeiro, António Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T06:38:56Zoai:estudogeral.uc.pt:10316/25400Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:40.381405Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neopterin in tuberculous and neoplastic pleural fluids
title Neopterin in tuberculous and neoplastic pleural fluids
spellingShingle Neopterin in tuberculous and neoplastic pleural fluids
Fontes Baganha, Manuel
Neopterina
title_short Neopterin in tuberculous and neoplastic pleural fluids
title_full Neopterin in tuberculous and neoplastic pleural fluids
title_fullStr Neopterin in tuberculous and neoplastic pleural fluids
title_full_unstemmed Neopterin in tuberculous and neoplastic pleural fluids
title_sort Neopterin in tuberculous and neoplastic pleural fluids
author Fontes Baganha, Manuel
author_facet Fontes Baganha, Manuel
Mota-Pinto, Anabela
Pêgo, Maria Alice
Marques, Maria Alcide
Santos-Rosa, Manuel
Robalo Cordeiro, António José
author_role author
author2 Mota-Pinto, Anabela
Pêgo, Maria Alice
Marques, Maria Alcide
Santos-Rosa, Manuel
Robalo Cordeiro, António José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fontes Baganha, Manuel
Mota-Pinto, Anabela
Pêgo, Maria Alice
Marques, Maria Alcide
Santos-Rosa, Manuel
Robalo Cordeiro, António José
dc.subject.por.fl_str_mv Neopterina
topic Neopterina
description Neopterin is derived from guanosine-triphosphate, produced by stimulated macrophages under the influence of gamma interferon of lymphocyte origin. It has been suggested as an excellent marker for activation of the monocyte/macrophage axis in some clinical situations. We evaluated its concentration in the pleural effusions of 25 individuals (10 tuberculous and 15 neoplastic) as well as in the blood of 22 of them (8 tuberculous and 14 neoplastic), comparing these levels with those of a control group in 99 normal individuals. The concentration of neopterin was determined by radioimmunologic assay. This showed a significant increase (p less than 0.001) of neopterin levels in the tuberculous pleural fluid, compared to the neoplastic group (42 +/- 23/17 +/- 9 nmol/L). In the blood, values were nearly identical to the pleural fluid (41.3 +/- 25/15.8 +/- 6.9 nmol/L), although with significant differences between them and in relation to the control group (p less than 0.001), which had a normal serum value (5.11 +/- 1.92 nmol/L). We emphasize the influence of the neopterin levels in the pleural fluid on the diagnosis of causes of pleurisy and its importance as a marker of immunologic cellular activity.
publishDate 1992
dc.date.none.fl_str_mv 1992
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/25400
http://hdl.handle.net/10316/25400
https://doi.org/10.1007/BF00174318
url http://hdl.handle.net/10316/25400
https://doi.org/10.1007/BF00174318
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