Elevated neopterin levels in non-allergic asthma

Detalhes bibliográficos
Autor(a) principal: Pinto, A. Mota
Data de Publicação: 2007
Outros Autores: Bom, A. Todo, Pereira, S. Vale, Alves, V., Rosa, M. Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/4717
https://doi.org/10.1016/j.pathophys.2006.10.001
Resumo: Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon- (IFN- ). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. In this study, we aimed to analyze the behaviour of neopterin in long lasting asthma considering its role as a marker of the Th1 environment and to establish the distinction between patients belonging either to the allergic or the non-allergic population, particularly in the elderly where asthma is often under diagnosed. Therefore we evaluated allergic parameters such as skin prick tests, IgE and hemogram (eosinophils count), and we compared our findings with neopterin values found in an age-matched control population. A group of individuals older than 65 was selected. It included 64 asthmatic patients (mean age 72±5 years) and 41 healthy individuals (mean age 79±7 years). In our study population, 42 patients presented positive skin tests, mainly to house dust mites. All patients were clinically stable and presented an average percentage of predicted forced expiratory volume in the first second (FEV1) of 73.6±25.3 and predicted median expiratory flow percentage (MEF50) of 38.8±26.7. Blood cell counts showed statistically different mean values of eosinophils between allergic and non-allergic controls (5.42±4.7% versus 2.8±2.8%; p < 0.04). IgE values were increased in allergic asthmatic patients when compared with non-allergic asthmatic patients (493.2±549.8 IU/ml versus 85.3±194.4 IU/ml; p = 0.000). Allergic asthmatic patients presented mean neopterin levels similar to those found in the control group (2.4±2.8 ng/ml versus 2.1±1.9 ng/ml). In contrast, in non-allergic asthmatic patients these values were higher when compared with the control group (4.0±4.7 ng/ml versus 2.1±1.9 ng/ml). Neopterin levels were lower in allergic asthmatic patients when compared with non-allergic asthmatic patients (2.4±2.8 ng/ml versus 4.0±4.7 ng/ml). Within asthmatic patients, those with higher neopterin values (>2.1 ng/ml) presented lower mean IgE values (IgE≤336.58 IU) than those with lower neopterin values (≤2.1 ng/ml) who presented mean IgE values of 402.70 IU. Our initial findings may lead to a better understanding of the immunoinflammatory pathways in asthma. Further studies will probably show that serum neopterin could became a useful marker for asthma classification including in elderly patients with long lasting disease.
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spelling Elevated neopterin levels in non-allergic asthmaNeopterinAllergyNeopterinaAsmaNeopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon- (IFN- ). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. In this study, we aimed to analyze the behaviour of neopterin in long lasting asthma considering its role as a marker of the Th1 environment and to establish the distinction between patients belonging either to the allergic or the non-allergic population, particularly in the elderly where asthma is often under diagnosed. Therefore we evaluated allergic parameters such as skin prick tests, IgE and hemogram (eosinophils count), and we compared our findings with neopterin values found in an age-matched control population. A group of individuals older than 65 was selected. It included 64 asthmatic patients (mean age 72±5 years) and 41 healthy individuals (mean age 79±7 years). In our study population, 42 patients presented positive skin tests, mainly to house dust mites. All patients were clinically stable and presented an average percentage of predicted forced expiratory volume in the first second (FEV1) of 73.6±25.3 and predicted median expiratory flow percentage (MEF50) of 38.8±26.7. Blood cell counts showed statistically different mean values of eosinophils between allergic and non-allergic controls (5.42±4.7% versus 2.8±2.8%; p < 0.04). IgE values were increased in allergic asthmatic patients when compared with non-allergic asthmatic patients (493.2±549.8 IU/ml versus 85.3±194.4 IU/ml; p = 0.000). Allergic asthmatic patients presented mean neopterin levels similar to those found in the control group (2.4±2.8 ng/ml versus 2.1±1.9 ng/ml). In contrast, in non-allergic asthmatic patients these values were higher when compared with the control group (4.0±4.7 ng/ml versus 2.1±1.9 ng/ml). Neopterin levels were lower in allergic asthmatic patients when compared with non-allergic asthmatic patients (2.4±2.8 ng/ml versus 4.0±4.7 ng/ml). Within asthmatic patients, those with higher neopterin values (>2.1 ng/ml) presented lower mean IgE values (IgE≤336.58 IU) than those with lower neopterin values (≤2.1 ng/ml) who presented mean IgE values of 402.70 IU. Our initial findings may lead to a better understanding of the immunoinflammatory pathways in asthma. Further studies will probably show that serum neopterin could became a useful marker for asthma classification including in elderly patients with long lasting disease.http://www.sciencedirect.com/science/article/B6TBB-4MCW9PR-1/1/bc45a63c4693fa42da0b7c7b88fbc9902007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4717http://hdl.handle.net/10316/4717https://doi.org/10.1016/j.pathophys.2006.10.001engPathophysiology. 14:1 (2007) 35-39http://www.sciencedirect.com/science/article/pii/S0928468006000897Pinto, A. MotaBom, A. TodoPereira, S. ValeAlves, V.Rosa, M. Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-08-19T15:40:11Zoai:estudogeral.uc.pt:10316/4717Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:34.413808Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Elevated neopterin levels in non-allergic asthma
title Elevated neopterin levels in non-allergic asthma
spellingShingle Elevated neopterin levels in non-allergic asthma
Pinto, A. Mota
Neopterin
Allergy
Neopterina
Asma
title_short Elevated neopterin levels in non-allergic asthma
title_full Elevated neopterin levels in non-allergic asthma
title_fullStr Elevated neopterin levels in non-allergic asthma
title_full_unstemmed Elevated neopterin levels in non-allergic asthma
title_sort Elevated neopterin levels in non-allergic asthma
author Pinto, A. Mota
author_facet Pinto, A. Mota
Bom, A. Todo
Pereira, S. Vale
Alves, V.
Rosa, M. Santos
author_role author
author2 Bom, A. Todo
Pereira, S. Vale
Alves, V.
Rosa, M. Santos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pinto, A. Mota
Bom, A. Todo
Pereira, S. Vale
Alves, V.
Rosa, M. Santos
dc.subject.por.fl_str_mv Neopterin
Allergy
Neopterina
Asma
topic Neopterin
Allergy
Neopterina
Asma
description Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon- (IFN- ). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. In this study, we aimed to analyze the behaviour of neopterin in long lasting asthma considering its role as a marker of the Th1 environment and to establish the distinction between patients belonging either to the allergic or the non-allergic population, particularly in the elderly where asthma is often under diagnosed. Therefore we evaluated allergic parameters such as skin prick tests, IgE and hemogram (eosinophils count), and we compared our findings with neopterin values found in an age-matched control population. A group of individuals older than 65 was selected. It included 64 asthmatic patients (mean age 72±5 years) and 41 healthy individuals (mean age 79±7 years). In our study population, 42 patients presented positive skin tests, mainly to house dust mites. All patients were clinically stable and presented an average percentage of predicted forced expiratory volume in the first second (FEV1) of 73.6±25.3 and predicted median expiratory flow percentage (MEF50) of 38.8±26.7. Blood cell counts showed statistically different mean values of eosinophils between allergic and non-allergic controls (5.42±4.7% versus 2.8±2.8%; p < 0.04). IgE values were increased in allergic asthmatic patients when compared with non-allergic asthmatic patients (493.2±549.8 IU/ml versus 85.3±194.4 IU/ml; p = 0.000). Allergic asthmatic patients presented mean neopterin levels similar to those found in the control group (2.4±2.8 ng/ml versus 2.1±1.9 ng/ml). In contrast, in non-allergic asthmatic patients these values were higher when compared with the control group (4.0±4.7 ng/ml versus 2.1±1.9 ng/ml). Neopterin levels were lower in allergic asthmatic patients when compared with non-allergic asthmatic patients (2.4±2.8 ng/ml versus 4.0±4.7 ng/ml). Within asthmatic patients, those with higher neopterin values (>2.1 ng/ml) presented lower mean IgE values (IgE≤336.58 IU) than those with lower neopterin values (≤2.1 ng/ml) who presented mean IgE values of 402.70 IU. Our initial findings may lead to a better understanding of the immunoinflammatory pathways in asthma. Further studies will probably show that serum neopterin could became a useful marker for asthma classification including in elderly patients with long lasting disease.
publishDate 2007
dc.date.none.fl_str_mv 2007
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/4717
http://hdl.handle.net/10316/4717
https://doi.org/10.1016/j.pathophys.2006.10.001
url http://hdl.handle.net/10316/4717
https://doi.org/10.1016/j.pathophys.2006.10.001
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Pathophysiology. 14:1 (2007) 35-39
http://www.sciencedirect.com/science/article/pii/S0928468006000897
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