The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort

Detalhes bibliográficos
Autor(a) principal: Franklin, Hannah D.
Data de Publicação: 2021
Outros Autores: Russell, Lucy L., Peakman, Georgia, Greaves, Caroline V., Bocchetta, Martina, Nicholas, Jennifer, Poos, Jackie, Convery, Rhian S., Cash, David M., van Swieten, John, Jiskoot, Lize, Miltenberger-Miltenyi, Gabriel, van Minkelen, Rick, Mitchell, Sara, Moore, Katrina, Nacmias, Benedetta, Nelson, Annabel, Öijerstedt, Linn, Olives, Jaume, Ourselin, Sebastien, Padovani, Alessandro, Moreno, Fermin, Panman, Jessica, Papma, Janne M., Pijnenburg, Yolande, Polito, Cristina, Premi, Enrico, Prioni, Sara, Prix, Catharina, Rademakers, Rosa, Redaelli, Veronica, Rinaldi, Daisy, Sanchez-Valle, Raquel, Rittman, Tim, Rogaeva, Ekaterina, Rollin, Adeline, Rosa-Neto, Pedro, Rossi, Giacomina, Rossor, Martin, Santiago, Beatriz, Saracino, Dario, Sayah, Sabrina, Scarpini, Elio, Borroni, Barbara, Schönecker, Sonja, Seelaar, Harro, Semler, Elisa, Shafei, Rachelle, Shoesmith, Christen, Swift, Imogen, Tábuas-Pereira, Miguel, Tainta, Mikel, Taipa, Ricardo, Tang-Wai, David, Laforce, Robert, Thomas, David L., Thompson, Paul, Thonberg, Hakan, Timberlake, Carolyn, Tiraboschi, Pietro, Todd, Emily, Van Damme, Philip, Vandenbulcke, Mathieu, Veldsman, Michele, Verdelho, Ana, Masellis, Mario, Villanua, Jorge, Warren, Jason, Wilke, Carlo, Woollacott, Ione, Wlasich, Elisabeth, Zetterberg, Henrik, Zulaica, Miren, Tartaglia, Maria Carmela, Graff, Caroline, Galimberti, Daniela, Rowe, James B., Finger, Elizabeth, Synofzik, Matthis, Vandenberghe, Rik, De Mendonça, Alexandre, Tagliavini, Fabrizio, Santana, Isabel, Ducharme, Simon, Butler, Chris, Gerhard, Alex, Levin, Johannes, Danek, Adrian, Otto, Markus, Sorbi, Sandro, Le Ber, Isabelle, Pasquier, Florence, Rohrer, Jonathan D., Afonso, Sónia, Almeida, Maria Rosario, Anderl-Straub, Sarah, Andersson, Christin, Antonell, Anna, Archetti, Silvana, Arighi, Andrea, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Benussi, Alberto, Bertoux, Maxime, Bertrand, Anne, Bessi, Valentina, Black, Sandra, Borrego-Ecija, Sergi, Bras, Jose, Brice, Alexis, Bruffaerts, Rose, Camuzat, Agnès, Cañada, Marta, Cantoni, Valentina, Caroppo, Paola, Castelo-Branco, Miguel, Colliot, Olivier, Cope, Thomas, Deramecourt, Vincent, de Arriba, María, Di Fede, Giuseppe, Díez, Alina, Duro, Diana, Fenoglio, Chiara, Ferrari, Camilla, Ferreira, Catarina B., Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Funkiewiez, Aurélie, Gabilondo, Alazne, Gasparotti, Roberto, Gauthier, Serge, Gazzina, Stefano, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Heller, Carolin, Hoegen, Tobias, Indakoetxea, Begoña, Jelic, Vesna, Karnath, Hans-Otto, Keren, Ron, Kuchcinski, Gregory, Langheinrich, Tobias, Lebouvier, Thibaud, Leitão, Maria João, Lladó, Albert, Lombardi, Gemma, Loosli, Sandra, Maruta, Carolina, Mead, Simon, Meeter, Lieke
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49174
Resumo: © The Author(s). 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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spelling The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohortC9orf72CDR® plus NACC FTLDFamilialFrontotemporal dementiaGRNMAPTRSMSVBM© The Author(s). 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Although social cognitive dysfunction is a major feature of frontotemporal dementia (FTD), it has been poorly studied in familial forms. A key goal of studies is to detect early cognitive impairment using validated measures in large patient cohorts. Methods: We used the Revised Self-Monitoring Scale (RSMS) as a measure of socioemotional sensitivity in 730 participants from the genetic FTD initiative (GENFI) observational study: 269 mutation-negative healthy controls, 193 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. All participants underwent the standardised GENFI clinical assessment including the 'CDR® plus NACC FTLD' scale and RSMS. The RSMS total score and its two subscores, socioemotional expressiveness (EX score) and modification of self-presentation (SP score) were measured. Volumetric T1-weighted magnetic resonance imaging was available from 377 mutation carriers for voxel-based morphometry (VBM) analysis. Results: The RSMS was decreased in symptomatic mutation carriers in all genetic groups but at a prodromal stage only in the C9orf72 (for the total score and both subscores) and GRN (for the modification of self-presentation subscore) groups. RSMS score correlated with disease severity in all groups. The VBM analysis implicated an overlapping network of regions including the orbitofrontal cortex, insula, temporal pole, medial temporal lobe and striatum. Conclusions: The RSMS indexes socioemotional impairment at an early stage of genetic FTD and may be a suitable outcome measure in forthcoming trials.The Dementia Research Centre is supported by Alzheimer’s Research UK, Brain Research Trust and The Wolfson Foundation. This work was supported by the NIHR Queen Square Dementia Biomedical Research Unit, the NIHR UCL/H Biomedical Research Centre and the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility as well as an Alzheimer’s Society grant [AS-PG-16-007]. This work was also supported by the MRC UK GENFI grant [MR/M023664/1], the Italian Ministry of Health (CoEN015 and Ricerca Corrente) and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, a Canadian Institutes of Health Research operating grant, The Bluefield Project and the JPND GENFI-PROX grant [2019-02248]. JDR is supported by an MRC Clinician Scientist Fellowship [MR/M008525/1] and has received funding from the NIHR Rare Disease Translational Research Collaboration [BRC149/NS/MH], the Bluefield Project and the Association for Frontotemporal Degeneration. MB is supported by a Fellowship award from the Alzheimer’s Society, UK [AS-JF-19a-004-517]. JBR is supported by the Wellcome Trust [103838], the Medical Research Council and NIHR Cambridge Biomedical Research Centre. This work was also funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology [EXC 2145 SyNergy – ID 390857198]. Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases - Project ID No 739510.Springer NatureRepositório da Universidade de LisboaFranklin, Hannah D.Russell, Lucy L.Peakman, GeorgiaGreaves, Caroline V.Bocchetta, MartinaNicholas, JenniferPoos, JackieConvery, Rhian S.Cash, David M.van Swieten, JohnJiskoot, LizeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraMoore, KatrinaNacmias, BenedettaNelson, AnnabelÖijerstedt, LinnOlives, JaumeOurselin, SebastienPadovani, AlessandroMoreno, FerminPanman, JessicaPapma, Janne M.Pijnenburg, YolandePolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRinaldi, DaisySanchez-Valle, RaquelRittman, TimRogaeva, EkaterinaRollin, AdelineRosa-Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizSaracino, DarioSayah, SabrinaScarpini, ElioBorroni, BarbaraSchönecker, SonjaSeelaar, HarroSemler, ElisaShafei, RachelleShoesmith, ChristenSwift, ImogenTábuas-Pereira, MiguelTainta, MikelTaipa, RicardoTang-Wai, DavidLaforce, RobertThomas, David L.Thompson, PaulThonberg, HakanTimberlake, CarolynTiraboschi, PietroTodd, EmilyVan Damme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaMasellis, MarioVillanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneWlasich, ElisabethZetterberg, HenrikZulaica, MirenTartaglia, Maria CarmelaGraff, CarolineGalimberti, DanielaRowe, James B.Finger, ElizabethSynofzik, MatthisVandenberghe, RikDe Mendonça, AlexandreTagliavini, FabrizioSantana, IsabelDucharme, SimonButler, ChrisGerhard, AlexLevin, JohannesDanek, AdrianOtto, MarkusSorbi, SandroLe Ber, IsabellePasquier, FlorenceRohrer, Jonathan D.Afonso, SóniaAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, AlbertoBertoux, MaximeBertrand, AnneBessi, ValentinaBlack, SandraBorrego-Ecija, SergiBras, JoseBrice, AlexisBruffaerts, RoseCamuzat, AgnèsCañada, MartaCantoni, ValentinaCaroppo, PaolaCastelo-Branco, MiguelColliot, OlivierCope, ThomasDeramecourt, Vincentde Arriba, MaríaDi Fede, GiuseppeDíez, AlinaDuro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, Catarina B.Fox, NickFreedman, MorrisFumagalli, GiorgioFunkiewiez, AurélieGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaKarnath, Hans-OttoKeren, RonKuchcinski, GregoryLangheinrich, TobiasLebouvier, ThibaudLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, Lieke2021-07-27T14:53:23Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49174engAlzheimers Res Ther. 2021 Jul 12;13(1):12710.1186/s13195-021-00865-w1758-9193info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:37Zoai:repositorio.ul.pt:10451/49174Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:47.033114Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
title The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
spellingShingle The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
Franklin, Hannah D.
C9orf72
CDR® plus NACC FTLD
Familial
Frontotemporal dementia
GRN
MAPT
RSMS
VBM
title_short The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
title_full The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
title_fullStr The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
title_full_unstemmed The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
title_sort The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
author Franklin, Hannah D.
author_facet Franklin, Hannah D.
Russell, Lucy L.
Peakman, Georgia
Greaves, Caroline V.
Bocchetta, Martina
Nicholas, Jennifer
Poos, Jackie
Convery, Rhian S.
Cash, David M.
van Swieten, John
Jiskoot, Lize
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Moore, Katrina
Nacmias, Benedetta
Nelson, Annabel
Öijerstedt, Linn
Olives, Jaume
Ourselin, Sebastien
Padovani, Alessandro
Moreno, Fermin
Panman, Jessica
Papma, Janne M.
Pijnenburg, Yolande
Polito, Cristina
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rinaldi, Daisy
Sanchez-Valle, Raquel
Rittman, Tim
Rogaeva, Ekaterina
Rollin, Adeline
Rosa-Neto, Pedro
Rossi, Giacomina
Rossor, Martin
Santiago, Beatriz
Saracino, Dario
Sayah, Sabrina
Scarpini, Elio
Borroni, Barbara
Schönecker, Sonja
Seelaar, Harro
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Swift, Imogen
Tábuas-Pereira, Miguel
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Laforce, Robert
Thomas, David L.
Thompson, Paul
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Todd, Emily
Van Damme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Masellis, Mario
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Woollacott, Ione
Wlasich, Elisabeth
Zetterberg, Henrik
Zulaica, Miren
Tartaglia, Maria Carmela
Graff, Caroline
Galimberti, Daniela
Rowe, James B.
Finger, Elizabeth
Synofzik, Matthis
Vandenberghe, Rik
De Mendonça, Alexandre
Tagliavini, Fabrizio
Santana, Isabel
Ducharme, Simon
Butler, Chris
Gerhard, Alex
Levin, Johannes
Danek, Adrian
Otto, Markus
Sorbi, Sandro
Le Ber, Isabelle
Pasquier, Florence
Rohrer, Jonathan D.
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Alberto
Bertoux, Maxime
Bertrand, Anne
Bessi, Valentina
Black, Sandra
Borrego-Ecija, Sergi
Bras, Jose
Brice, Alexis
Bruffaerts, Rose
Camuzat, Agnès
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Castelo-Branco, Miguel
Colliot, Olivier
Cope, Thomas
Deramecourt, Vincent
de Arriba, María
Di Fede, Giuseppe
Díez, Alina
Duro, Diana
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Funkiewiez, Aurélie
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Gazzina, Stefano
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Karnath, Hans-Otto
Keren, Ron
Kuchcinski, Gregory
Langheinrich, Tobias
Lebouvier, Thibaud
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
author_role author
author2 Russell, Lucy L.
Peakman, Georgia
Greaves, Caroline V.
Bocchetta, Martina
Nicholas, Jennifer
Poos, Jackie
Convery, Rhian S.
Cash, David M.
van Swieten, John
Jiskoot, Lize
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Moore, Katrina
Nacmias, Benedetta
Nelson, Annabel
Öijerstedt, Linn
Olives, Jaume
Ourselin, Sebastien
Padovani, Alessandro
Moreno, Fermin
Panman, Jessica
Papma, Janne M.
Pijnenburg, Yolande
Polito, Cristina
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rinaldi, Daisy
Sanchez-Valle, Raquel
Rittman, Tim
Rogaeva, Ekaterina
Rollin, Adeline
Rosa-Neto, Pedro
Rossi, Giacomina
Rossor, Martin
Santiago, Beatriz
Saracino, Dario
Sayah, Sabrina
Scarpini, Elio
Borroni, Barbara
Schönecker, Sonja
Seelaar, Harro
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Swift, Imogen
Tábuas-Pereira, Miguel
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Laforce, Robert
Thomas, David L.
Thompson, Paul
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Todd, Emily
Van Damme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Masellis, Mario
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Woollacott, Ione
Wlasich, Elisabeth
Zetterberg, Henrik
Zulaica, Miren
Tartaglia, Maria Carmela
Graff, Caroline
Galimberti, Daniela
Rowe, James B.
Finger, Elizabeth
Synofzik, Matthis
Vandenberghe, Rik
De Mendonça, Alexandre
Tagliavini, Fabrizio
Santana, Isabel
Ducharme, Simon
Butler, Chris
Gerhard, Alex
Levin, Johannes
Danek, Adrian
Otto, Markus
Sorbi, Sandro
Le Ber, Isabelle
Pasquier, Florence
Rohrer, Jonathan D.
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Alberto
Bertoux, Maxime
Bertrand, Anne
Bessi, Valentina
Black, Sandra
Borrego-Ecija, Sergi
Bras, Jose
Brice, Alexis
Bruffaerts, Rose
Camuzat, Agnès
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Castelo-Branco, Miguel
Colliot, Olivier
Cope, Thomas
Deramecourt, Vincent
de Arriba, María
Di Fede, Giuseppe
Díez, Alina
Duro, Diana
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Funkiewiez, Aurélie
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Gazzina, Stefano
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Karnath, Hans-Otto
Keren, Ron
Kuchcinski, Gregory
Langheinrich, Tobias
Lebouvier, Thibaud
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Franklin, Hannah D.
Russell, Lucy L.
Peakman, Georgia
Greaves, Caroline V.
Bocchetta, Martina
Nicholas, Jennifer
Poos, Jackie
Convery, Rhian S.
Cash, David M.
van Swieten, John
Jiskoot, Lize
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Moore, Katrina
Nacmias, Benedetta
Nelson, Annabel
Öijerstedt, Linn
Olives, Jaume
Ourselin, Sebastien
Padovani, Alessandro
Moreno, Fermin
Panman, Jessica
Papma, Janne M.
Pijnenburg, Yolande
Polito, Cristina
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rinaldi, Daisy
Sanchez-Valle, Raquel
Rittman, Tim
Rogaeva, Ekaterina
Rollin, Adeline
Rosa-Neto, Pedro
Rossi, Giacomina
Rossor, Martin
Santiago, Beatriz
Saracino, Dario
Sayah, Sabrina
Scarpini, Elio
Borroni, Barbara
Schönecker, Sonja
Seelaar, Harro
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Swift, Imogen
Tábuas-Pereira, Miguel
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Laforce, Robert
Thomas, David L.
Thompson, Paul
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Todd, Emily
Van Damme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Masellis, Mario
Villanua, Jorge
Warren, Jason
Wilke, Carlo
Woollacott, Ione
Wlasich, Elisabeth
Zetterberg, Henrik
Zulaica, Miren
Tartaglia, Maria Carmela
Graff, Caroline
Galimberti, Daniela
Rowe, James B.
Finger, Elizabeth
Synofzik, Matthis
Vandenberghe, Rik
De Mendonça, Alexandre
Tagliavini, Fabrizio
Santana, Isabel
Ducharme, Simon
Butler, Chris
Gerhard, Alex
Levin, Johannes
Danek, Adrian
Otto, Markus
Sorbi, Sandro
Le Ber, Isabelle
Pasquier, Florence
Rohrer, Jonathan D.
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Alberto
Bertoux, Maxime
Bertrand, Anne
Bessi, Valentina
Black, Sandra
Borrego-Ecija, Sergi
Bras, Jose
Brice, Alexis
Bruffaerts, Rose
Camuzat, Agnès
Cañada, Marta
Cantoni, Valentina
Caroppo, Paola
Castelo-Branco, Miguel
Colliot, Olivier
Cope, Thomas
Deramecourt, Vincent
de Arriba, María
Di Fede, Giuseppe
Díez, Alina
Duro, Diana
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Funkiewiez, Aurélie
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Gazzina, Stefano
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Karnath, Hans-Otto
Keren, Ron
Kuchcinski, Gregory
Langheinrich, Tobias
Lebouvier, Thibaud
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
dc.subject.por.fl_str_mv C9orf72
CDR® plus NACC FTLD
Familial
Frontotemporal dementia
GRN
MAPT
RSMS
VBM
topic C9orf72
CDR® plus NACC FTLD
Familial
Frontotemporal dementia
GRN
MAPT
RSMS
VBM
description © The Author(s). 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-27T14:53:23Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49174
url http://hdl.handle.net/10451/49174
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Alzheimers Res Ther. 2021 Jul 12;13(1):127
10.1186/s13195-021-00865-w
1758-9193
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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