The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/49174 |
Resumo: | © The Author(s). 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohortC9orf72CDR® plus NACC FTLDFamilialFrontotemporal dementiaGRNMAPTRSMSVBM© The Author(s). 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Although social cognitive dysfunction is a major feature of frontotemporal dementia (FTD), it has been poorly studied in familial forms. A key goal of studies is to detect early cognitive impairment using validated measures in large patient cohorts. Methods: We used the Revised Self-Monitoring Scale (RSMS) as a measure of socioemotional sensitivity in 730 participants from the genetic FTD initiative (GENFI) observational study: 269 mutation-negative healthy controls, 193 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. All participants underwent the standardised GENFI clinical assessment including the 'CDR® plus NACC FTLD' scale and RSMS. The RSMS total score and its two subscores, socioemotional expressiveness (EX score) and modification of self-presentation (SP score) were measured. Volumetric T1-weighted magnetic resonance imaging was available from 377 mutation carriers for voxel-based morphometry (VBM) analysis. Results: The RSMS was decreased in symptomatic mutation carriers in all genetic groups but at a prodromal stage only in the C9orf72 (for the total score and both subscores) and GRN (for the modification of self-presentation subscore) groups. RSMS score correlated with disease severity in all groups. The VBM analysis implicated an overlapping network of regions including the orbitofrontal cortex, insula, temporal pole, medial temporal lobe and striatum. Conclusions: The RSMS indexes socioemotional impairment at an early stage of genetic FTD and may be a suitable outcome measure in forthcoming trials.The Dementia Research Centre is supported by Alzheimer’s Research UK, Brain Research Trust and The Wolfson Foundation. This work was supported by the NIHR Queen Square Dementia Biomedical Research Unit, the NIHR UCL/H Biomedical Research Centre and the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility as well as an Alzheimer’s Society grant [AS-PG-16-007]. This work was also supported by the MRC UK GENFI grant [MR/M023664/1], the Italian Ministry of Health (CoEN015 and Ricerca Corrente) and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, a Canadian Institutes of Health Research operating grant, The Bluefield Project and the JPND GENFI-PROX grant [2019-02248]. JDR is supported by an MRC Clinician Scientist Fellowship [MR/M008525/1] and has received funding from the NIHR Rare Disease Translational Research Collaboration [BRC149/NS/MH], the Bluefield Project and the Association for Frontotemporal Degeneration. MB is supported by a Fellowship award from the Alzheimer’s Society, UK [AS-JF-19a-004-517]. JBR is supported by the Wellcome Trust [103838], the Medical Research Council and NIHR Cambridge Biomedical Research Centre. This work was also funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology [EXC 2145 SyNergy – ID 390857198]. Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases - Project ID No 739510.Springer NatureRepositório da Universidade de LisboaFranklin, Hannah D.Russell, Lucy L.Peakman, GeorgiaGreaves, Caroline V.Bocchetta, MartinaNicholas, JenniferPoos, JackieConvery, Rhian S.Cash, David M.van Swieten, JohnJiskoot, LizeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraMoore, KatrinaNacmias, BenedettaNelson, AnnabelÖijerstedt, LinnOlives, JaumeOurselin, SebastienPadovani, AlessandroMoreno, FerminPanman, JessicaPapma, Janne M.Pijnenburg, YolandePolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRinaldi, DaisySanchez-Valle, RaquelRittman, TimRogaeva, EkaterinaRollin, AdelineRosa-Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizSaracino, DarioSayah, SabrinaScarpini, ElioBorroni, BarbaraSchönecker, SonjaSeelaar, HarroSemler, ElisaShafei, RachelleShoesmith, ChristenSwift, ImogenTábuas-Pereira, MiguelTainta, MikelTaipa, RicardoTang-Wai, DavidLaforce, RobertThomas, David L.Thompson, PaulThonberg, HakanTimberlake, CarolynTiraboschi, PietroTodd, EmilyVan Damme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaMasellis, MarioVillanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneWlasich, ElisabethZetterberg, HenrikZulaica, MirenTartaglia, Maria CarmelaGraff, CarolineGalimberti, DanielaRowe, James B.Finger, ElizabethSynofzik, MatthisVandenberghe, RikDe Mendonça, AlexandreTagliavini, FabrizioSantana, IsabelDucharme, SimonButler, ChrisGerhard, AlexLevin, JohannesDanek, AdrianOtto, MarkusSorbi, SandroLe Ber, IsabellePasquier, FlorenceRohrer, Jonathan D.Afonso, SóniaAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, AlbertoBertoux, MaximeBertrand, AnneBessi, ValentinaBlack, SandraBorrego-Ecija, SergiBras, JoseBrice, AlexisBruffaerts, RoseCamuzat, AgnèsCañada, MartaCantoni, ValentinaCaroppo, PaolaCastelo-Branco, MiguelColliot, OlivierCope, ThomasDeramecourt, Vincentde Arriba, MaríaDi Fede, GiuseppeDíez, AlinaDuro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, Catarina B.Fox, NickFreedman, MorrisFumagalli, GiorgioFunkiewiez, AurélieGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaKarnath, Hans-OttoKeren, RonKuchcinski, GregoryLangheinrich, TobiasLebouvier, ThibaudLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, Lieke2021-07-27T14:53:23Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49174engAlzheimers Res Ther. 2021 Jul 12;13(1):12710.1186/s13195-021-00865-w1758-9193info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:37Zoai:repositorio.ul.pt:10451/49174Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:47.033114Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
title |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
spellingShingle |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort Franklin, Hannah D. C9orf72 CDR® plus NACC FTLD Familial Frontotemporal dementia GRN MAPT RSMS VBM |
title_short |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
title_full |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
title_fullStr |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
title_full_unstemmed |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
title_sort |
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort |
author |
Franklin, Hannah D. |
author_facet |
Franklin, Hannah D. Russell, Lucy L. Peakman, Georgia Greaves, Caroline V. Bocchetta, Martina Nicholas, Jennifer Poos, Jackie Convery, Rhian S. Cash, David M. van Swieten, John Jiskoot, Lize Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nacmias, Benedetta Nelson, Annabel Öijerstedt, Linn Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Moreno, Fermin Panman, Jessica Papma, Janne M. Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Sanchez-Valle, Raquel Rittman, Tim Rogaeva, Ekaterina Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Saracino, Dario Sayah, Sabrina Scarpini, Elio Borroni, Barbara Schönecker, Sonja Seelaar, Harro Semler, Elisa Shafei, Rachelle Shoesmith, Christen Swift, Imogen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Laforce, Robert Thomas, David L. Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Todd, Emily Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Masellis, Mario Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren Tartaglia, Maria Carmela Graff, Caroline Galimberti, Daniela Rowe, James B. Finger, Elizabeth Synofzik, Matthis Vandenberghe, Rik De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alex Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Le Ber, Isabelle Pasquier, Florence Rohrer, Jonathan D. Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Alberto Bertoux, Maxime Bertrand, Anne Bessi, Valentina Black, Sandra Borrego-Ecija, Sergi Bras, Jose Brice, Alexis Bruffaerts, Rose Camuzat, Agnès Cañada, Marta Cantoni, Valentina Caroppo, Paola Castelo-Branco, Miguel Colliot, Olivier Cope, Thomas Deramecourt, Vincent de Arriba, María Di Fede, Giuseppe Díez, Alina Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke |
author_role |
author |
author2 |
Russell, Lucy L. Peakman, Georgia Greaves, Caroline V. Bocchetta, Martina Nicholas, Jennifer Poos, Jackie Convery, Rhian S. Cash, David M. van Swieten, John Jiskoot, Lize Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nacmias, Benedetta Nelson, Annabel Öijerstedt, Linn Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Moreno, Fermin Panman, Jessica Papma, Janne M. Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Sanchez-Valle, Raquel Rittman, Tim Rogaeva, Ekaterina Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Saracino, Dario Sayah, Sabrina Scarpini, Elio Borroni, Barbara Schönecker, Sonja Seelaar, Harro Semler, Elisa Shafei, Rachelle Shoesmith, Christen Swift, Imogen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Laforce, Robert Thomas, David L. Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Todd, Emily Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Masellis, Mario Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren Tartaglia, Maria Carmela Graff, Caroline Galimberti, Daniela Rowe, James B. Finger, Elizabeth Synofzik, Matthis Vandenberghe, Rik De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alex Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Le Ber, Isabelle Pasquier, Florence Rohrer, Jonathan D. Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Alberto Bertoux, Maxime Bertrand, Anne Bessi, Valentina Black, Sandra Borrego-Ecija, Sergi Bras, Jose Brice, Alexis Bruffaerts, Rose Camuzat, Agnès Cañada, Marta Cantoni, Valentina Caroppo, Paola Castelo-Branco, Miguel Colliot, Olivier Cope, Thomas Deramecourt, Vincent de Arriba, María Di Fede, Giuseppe Díez, Alina Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Franklin, Hannah D. Russell, Lucy L. Peakman, Georgia Greaves, Caroline V. Bocchetta, Martina Nicholas, Jennifer Poos, Jackie Convery, Rhian S. Cash, David M. van Swieten, John Jiskoot, Lize Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Moore, Katrina Nacmias, Benedetta Nelson, Annabel Öijerstedt, Linn Olives, Jaume Ourselin, Sebastien Padovani, Alessandro Moreno, Fermin Panman, Jessica Papma, Janne M. Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rinaldi, Daisy Sanchez-Valle, Raquel Rittman, Tim Rogaeva, Ekaterina Rollin, Adeline Rosa-Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Saracino, Dario Sayah, Sabrina Scarpini, Elio Borroni, Barbara Schönecker, Sonja Seelaar, Harro Semler, Elisa Shafei, Rachelle Shoesmith, Christen Swift, Imogen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Laforce, Robert Thomas, David L. Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Todd, Emily Van Damme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Masellis, Mario Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren Tartaglia, Maria Carmela Graff, Caroline Galimberti, Daniela Rowe, James B. Finger, Elizabeth Synofzik, Matthis Vandenberghe, Rik De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alex Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Le Ber, Isabelle Pasquier, Florence Rohrer, Jonathan D. Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Alberto Bertoux, Maxime Bertrand, Anne Bessi, Valentina Black, Sandra Borrego-Ecija, Sergi Bras, Jose Brice, Alexis Bruffaerts, Rose Camuzat, Agnès Cañada, Marta Cantoni, Valentina Caroppo, Paola Castelo-Branco, Miguel Colliot, Olivier Cope, Thomas Deramecourt, Vincent de Arriba, María Di Fede, Giuseppe Díez, Alina Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Fox, Nick Freedman, Morris Fumagalli, Giorgio Funkiewiez, Aurélie Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Karnath, Hans-Otto Keren, Ron Kuchcinski, Gregory Langheinrich, Tobias Lebouvier, Thibaud Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke |
dc.subject.por.fl_str_mv |
C9orf72 CDR® plus NACC FTLD Familial Frontotemporal dementia GRN MAPT RSMS VBM |
topic |
C9orf72 CDR® plus NACC FTLD Familial Frontotemporal dementia GRN MAPT RSMS VBM |
description |
© The Author(s). 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-27T14:53:23Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/49174 |
url |
http://hdl.handle.net/10451/49174 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.none.fl_str_mv |
Alzheimers Res Ther. 2021 Jul 12;13(1):127 10.1186/s13195-021-00865-w 1758-9193 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
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