Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/46285 |
Resumo: | © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
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Social cognition impairment in genetic frontotemporal dementia within the GENFI cohortFrontotemporal dementiaTheory of mindEmotion processingFaux pasFacial emotion recognitionC9orf72ProgranulinMAPT© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).A key symptom of frontotemporal dementia (FTD) is difficulty interacting socially with others. Social cognition problems in FTD include impaired emotion processing and theory of mind difficulties, and whilst these have been studied extensively in sporadic FTD, few studies have investigated them in familial FTD. Facial Emotion Recognition (FER) and Faux Pas (FP) recognition tests were used to study social cognition within the Genetic Frontotemporal Dementia Initiative (GENFI), a large familial FTD cohort of C9orf72, GRN, and MAPT mutation carriers. 627 participants undertook at least one of the tasks, and were separated into mutation-negative healthy controls, presymptomatic mutation carriers (split into early and late groups) and symptomatic mutation carriers. Groups were compared using a linear regression model with bootstrapping, adjusting for age, sex, education, and for the FP recognition test, language. Neural correlates of social cognition deficits were explored using a voxel-based morphometry (VBM) study. All three of the symptomatic genetic groups were impaired on both tasks with no significant difference between them. However, prior to onset, only the late presymptomatic C9orf72 mutation carriers on the FER test were impaired compared to the control group, with a subanalysis showing differences particularly in fear and sadness. The VBM analysis revealed that impaired social cognition was mainly associated with a left hemisphere predominant network of regions involving particularly the striatum, orbitofrontal cortex and insula, and to a lesser extent the inferomedial temporal lobe and other areas of the frontal lobe. In conclusion, theory of mind and emotion processing abilities are impaired in familial FTD, with early changes occurring prior to symptom onset in C9orf72 presymptomatic mutation carriers. Future work should investigate how performance changes over time, in order to gain a clearer insight into social cognitive impairment over the course of the disease.ElsevierRepositório da Universidade de LisboaRussell, Lucy L.Greaves, Caroline V.Bocchetta, MartinaNicholas, JenniferConvery, Rhian S.Moore, KatrinaCash, David M.van Swieten, JohnJiskoot, LizeMoreno, FerminSanchez-Valle, RaquelScarpini, ElioFumagalli, GiorgioTaipa, RicardoCope, ThomasTimberlake, CarolynRittman, TimothyShoesmith, ChristenBartha, RobartRademakers, RosaWilke, CarloTiraboschi, PietroKarnarth, Hans-OttoBender, BenjaminBruffaerts, RoseCaroppo, PaolaVandamme, PhilipVandenbulcke, MathieuFerreira, Catarina B.Miltenberger-Miltenyi, GabrielMaruta, CarolinaVerdelho, AnaDuro NPsych, DianaAfonso, SóniaDi Fede, GiuseppeGiaccone, GiorgioMuscio, CristinaPrioni, SaraRedaelli, VeronicaRossi, GiacominaBorroni, BarbaraAlmeida, Maria R.Castelo-Branco, MiguelLeitão, Maria J.Tabuas-Pereira, MiguelSantiago, BeatrizGauthier, SergeRosa-Neto, PedroFinger, ElizabethVeldsman, MicheleThompson, PaulLangheinrich, TobiasLaforce, RobertPrix, CatharinaHoegen, TobiasWlasich, ElisabethLoosli, SandraSchonecker, SonjaSemler, ElisaSynofzik, MatthisAnderl-Straub, SarahMasellis, MarioTartaglia, Maria CarmelaGraff, CarolineRotondo, EmanuelaGalimberti, DanielaRowe, James B.Vandenberghe, RikDe Mendonça, AlexandreTagliavini, FabrizioSantana, IsabelDucharme, SimonButler, ChrisGerhard, AlexLevin, Johannesvan Minkelen, RickDanek, AdrianOtto, MarkusWarren, Jason D.Rohrer, Jonathan D.Rossor, Martin N.Fox, Nick C.Woollacott, Ione O.C.Shafei, RachelleHeller, CarolinGuerreiro, RitaPijnenburg, YolandaBras, JoseThomas, David L.Mead, SimonMeeter, LiekePanman, JessicaPapma, JannePoos, JackieBarandiaran, MyriamIndakoetxea, BegoñaGabilondo, AlazneTainta, Mikelde Arriba, MariaGorostidi, AnaZulaica, MirenVillanua, JorgeKeren, RonDiaz, ZigorBorrego-Ecija, SergiOlives, JaumeLladó, AlbertBalasa, MirceaAntonell, AnnaBargallo, NuriaPremi, EnricoCosseddu MPsych, MauraGazzina, StefanoTang-Wai, DaidPadovani, AlessandroGasparotti, RobertoArchetti, SilvanaBlack, SandraMitchell, SaraRogaeva, EkaterinaFreedman, MorrisÖijerstedt, LinnAndersson, ChristinJelic, VesnaThonberg, HakanArighi, AndreaFenoglio, Chiara2021-02-11T13:53:40Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46285engCortex. 2020 Dec;133:384-3980010-945210.1016/j.cortex.2020.08.0231973-8102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:32Zoai:repositorio.ul.pt:10451/46285Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:31.621080Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| title |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| spellingShingle |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort Russell, Lucy L. Frontotemporal dementia Theory of mind Emotion processing Faux pas Facial emotion recognition C9orf72 Progranulin MAPT |
| title_short |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| title_full |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| title_fullStr |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| title_full_unstemmed |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| title_sort |
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort |
| author |
Russell, Lucy L. |
| author_facet |
Russell, Lucy L. Greaves, Caroline V. Bocchetta, Martina Nicholas, Jennifer Convery, Rhian S. Moore, Katrina Cash, David M. van Swieten, John Jiskoot, Lize Moreno, Fermin Sanchez-Valle, Raquel Scarpini, Elio Fumagalli, Giorgio Taipa, Ricardo Cope, Thomas Timberlake, Carolyn Rittman, Timothy Shoesmith, Christen Bartha, Robart Rademakers, Rosa Wilke, Carlo Tiraboschi, Pietro Karnarth, Hans-Otto Bender, Benjamin Bruffaerts, Rose Caroppo, Paola Vandamme, Philip Vandenbulcke, Mathieu Ferreira, Catarina B. Miltenberger-Miltenyi, Gabriel Maruta, Carolina Verdelho, Ana Duro NPsych, Diana Afonso, Sónia Di Fede, Giuseppe Giaccone, Giorgio Muscio, Cristina Prioni, Sara Redaelli, Veronica Rossi, Giacomina Borroni, Barbara Almeida, Maria R. Castelo-Branco, Miguel Leitão, Maria J. Tabuas-Pereira, Miguel Santiago, Beatriz Gauthier, Serge Rosa-Neto, Pedro Finger, Elizabeth Veldsman, Michele Thompson, Paul Langheinrich, Tobias Laforce, Robert Prix, Catharina Hoegen, Tobias Wlasich, Elisabeth Loosli, Sandra Schonecker, Sonja Semler, Elisa Synofzik, Matthis Anderl-Straub, Sarah Masellis, Mario Tartaglia, Maria Carmela Graff, Caroline Rotondo, Emanuela Galimberti, Daniela Rowe, James B. Vandenberghe, Rik De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alex Levin, Johannes van Minkelen, Rick Danek, Adrian Otto, Markus Warren, Jason D. Rohrer, Jonathan D. Rossor, Martin N. Fox, Nick C. Woollacott, Ione O.C. Shafei, Rachelle Heller, Carolin Guerreiro, Rita Pijnenburg, Yolanda Bras, Jose Thomas, David L. Mead, Simon Meeter, Lieke Panman, Jessica Papma, Janne Poos, Jackie Barandiaran, Myriam Indakoetxea, Begoña Gabilondo, Alazne Tainta, Mikel de Arriba, Maria Gorostidi, Ana Zulaica, Miren Villanua, Jorge Keren, Ron Diaz, Zigor Borrego-Ecija, Sergi Olives, Jaume Lladó, Albert Balasa, Mircea Antonell, Anna Bargallo, Nuria Premi, Enrico Cosseddu MPsych, Maura Gazzina, Stefano Tang-Wai, Daid Padovani, Alessandro Gasparotti, Roberto Archetti, Silvana Black, Sandra Mitchell, Sara Rogaeva, Ekaterina Freedman, Morris Öijerstedt, Linn Andersson, Christin Jelic, Vesna Thonberg, Hakan Arighi, Andrea Fenoglio, Chiara |
| author_role |
author |
| author2 |
Greaves, Caroline V. Bocchetta, Martina Nicholas, Jennifer Convery, Rhian S. Moore, Katrina Cash, David M. van Swieten, John Jiskoot, Lize Moreno, Fermin Sanchez-Valle, Raquel Scarpini, Elio Fumagalli, Giorgio Taipa, Ricardo Cope, Thomas Timberlake, Carolyn Rittman, Timothy Shoesmith, Christen Bartha, Robart Rademakers, Rosa Wilke, Carlo Tiraboschi, Pietro Karnarth, Hans-Otto Bender, Benjamin Bruffaerts, Rose Caroppo, Paola Vandamme, Philip Vandenbulcke, Mathieu Ferreira, Catarina B. Miltenberger-Miltenyi, Gabriel Maruta, Carolina Verdelho, Ana Duro NPsych, Diana Afonso, Sónia Di Fede, Giuseppe Giaccone, Giorgio Muscio, Cristina Prioni, Sara Redaelli, Veronica Rossi, Giacomina Borroni, Barbara Almeida, Maria R. Castelo-Branco, Miguel Leitão, Maria J. Tabuas-Pereira, Miguel Santiago, Beatriz Gauthier, Serge Rosa-Neto, Pedro Finger, Elizabeth Veldsman, Michele Thompson, Paul Langheinrich, Tobias Laforce, Robert Prix, Catharina Hoegen, Tobias Wlasich, Elisabeth Loosli, Sandra Schonecker, Sonja Semler, Elisa Synofzik, Matthis Anderl-Straub, Sarah Masellis, Mario Tartaglia, Maria Carmela Graff, Caroline Rotondo, Emanuela Galimberti, Daniela Rowe, James B. Vandenberghe, Rik De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alex Levin, Johannes van Minkelen, Rick Danek, Adrian Otto, Markus Warren, Jason D. Rohrer, Jonathan D. Rossor, Martin N. Fox, Nick C. Woollacott, Ione O.C. Shafei, Rachelle Heller, Carolin Guerreiro, Rita Pijnenburg, Yolanda Bras, Jose Thomas, David L. Mead, Simon Meeter, Lieke Panman, Jessica Papma, Janne Poos, Jackie Barandiaran, Myriam Indakoetxea, Begoña Gabilondo, Alazne Tainta, Mikel de Arriba, Maria Gorostidi, Ana Zulaica, Miren Villanua, Jorge Keren, Ron Diaz, Zigor Borrego-Ecija, Sergi Olives, Jaume Lladó, Albert Balasa, Mircea Antonell, Anna Bargallo, Nuria Premi, Enrico Cosseddu MPsych, Maura Gazzina, Stefano Tang-Wai, Daid Padovani, Alessandro Gasparotti, Roberto Archetti, Silvana Black, Sandra Mitchell, Sara Rogaeva, Ekaterina Freedman, Morris Öijerstedt, Linn Andersson, Christin Jelic, Vesna Thonberg, Hakan Arighi, Andrea Fenoglio, Chiara |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Russell, Lucy L. Greaves, Caroline V. Bocchetta, Martina Nicholas, Jennifer Convery, Rhian S. Moore, Katrina Cash, David M. van Swieten, John Jiskoot, Lize Moreno, Fermin Sanchez-Valle, Raquel Scarpini, Elio Fumagalli, Giorgio Taipa, Ricardo Cope, Thomas Timberlake, Carolyn Rittman, Timothy Shoesmith, Christen Bartha, Robart Rademakers, Rosa Wilke, Carlo Tiraboschi, Pietro Karnarth, Hans-Otto Bender, Benjamin Bruffaerts, Rose Caroppo, Paola Vandamme, Philip Vandenbulcke, Mathieu Ferreira, Catarina B. Miltenberger-Miltenyi, Gabriel Maruta, Carolina Verdelho, Ana Duro NPsych, Diana Afonso, Sónia Di Fede, Giuseppe Giaccone, Giorgio Muscio, Cristina Prioni, Sara Redaelli, Veronica Rossi, Giacomina Borroni, Barbara Almeida, Maria R. Castelo-Branco, Miguel Leitão, Maria J. Tabuas-Pereira, Miguel Santiago, Beatriz Gauthier, Serge Rosa-Neto, Pedro Finger, Elizabeth Veldsman, Michele Thompson, Paul Langheinrich, Tobias Laforce, Robert Prix, Catharina Hoegen, Tobias Wlasich, Elisabeth Loosli, Sandra Schonecker, Sonja Semler, Elisa Synofzik, Matthis Anderl-Straub, Sarah Masellis, Mario Tartaglia, Maria Carmela Graff, Caroline Rotondo, Emanuela Galimberti, Daniela Rowe, James B. Vandenberghe, Rik De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alex Levin, Johannes van Minkelen, Rick Danek, Adrian Otto, Markus Warren, Jason D. Rohrer, Jonathan D. Rossor, Martin N. Fox, Nick C. Woollacott, Ione O.C. Shafei, Rachelle Heller, Carolin Guerreiro, Rita Pijnenburg, Yolanda Bras, Jose Thomas, David L. Mead, Simon Meeter, Lieke Panman, Jessica Papma, Janne Poos, Jackie Barandiaran, Myriam Indakoetxea, Begoña Gabilondo, Alazne Tainta, Mikel de Arriba, Maria Gorostidi, Ana Zulaica, Miren Villanua, Jorge Keren, Ron Diaz, Zigor Borrego-Ecija, Sergi Olives, Jaume Lladó, Albert Balasa, Mircea Antonell, Anna Bargallo, Nuria Premi, Enrico Cosseddu MPsych, Maura Gazzina, Stefano Tang-Wai, Daid Padovani, Alessandro Gasparotti, Roberto Archetti, Silvana Black, Sandra Mitchell, Sara Rogaeva, Ekaterina Freedman, Morris Öijerstedt, Linn Andersson, Christin Jelic, Vesna Thonberg, Hakan Arighi, Andrea Fenoglio, Chiara |
| dc.subject.por.fl_str_mv |
Frontotemporal dementia Theory of mind Emotion processing Faux pas Facial emotion recognition C9orf72 Progranulin MAPT |
| topic |
Frontotemporal dementia Theory of mind Emotion processing Faux pas Facial emotion recognition C9orf72 Progranulin MAPT |
| description |
© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-02-11T13:53:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/46285 |
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http://hdl.handle.net/10451/46285 |
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eng |
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eng |
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Cortex. 2020 Dec;133:384-398 0010-9452 10.1016/j.cortex.2020.08.023 1973-8102 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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