Protein micro- and nano-capsules for biomedical applications

Detalhes bibliográficos
Autor(a) principal: Shimanovich, Ulyana
Data de Publicação: 2014
Outros Autores: Bernardes, Gonçalo J. L., Knowles, T. P. J., Paulo, Artur Cavaco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/28584
Resumo: Micro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules.
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spelling Protein micro- and nano-capsules for biomedical applicationsScience & TechnologyMicro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules.U.S. is grateful to Professor Aharon Gedanken, Chemistry Department, Bar-Ilan University, Israel, for his support and supervision during her PhD research work. G.J.L.B. is a Royal Society University Research Fellow at the Department of Chemistry, University of Cambridge and an Investigador FCT at the Instituto de Medicina Molecular, Lisboa. We thank Nuno Azoia assistance with the preparation of the figures. The authors thank the European Union Seventh Framework Programme (FP7/20072013) under grant agreement NMP4-LA-2009-228827 NANOFOL.Royal Society of ChemistryUniversidade do MinhoShimanovich, UlyanaBernardes, Gonçalo J. L.Knowles, T. P. J.Paulo, Artur Cavaco20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/28584engChemical Society Reviews, 43(5), 1361-1371, 20140306-001210.1039/C3CS60376H24336689info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:04:40Zoai:repositorium.sdum.uminho.pt:1822/28584Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:54:58.287729Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Protein micro- and nano-capsules for biomedical applications
title Protein micro- and nano-capsules for biomedical applications
spellingShingle Protein micro- and nano-capsules for biomedical applications
Shimanovich, Ulyana
Science & Technology
title_short Protein micro- and nano-capsules for biomedical applications
title_full Protein micro- and nano-capsules for biomedical applications
title_fullStr Protein micro- and nano-capsules for biomedical applications
title_full_unstemmed Protein micro- and nano-capsules for biomedical applications
title_sort Protein micro- and nano-capsules for biomedical applications
author Shimanovich, Ulyana
author_facet Shimanovich, Ulyana
Bernardes, Gonçalo J. L.
Knowles, T. P. J.
Paulo, Artur Cavaco
author_role author
author2 Bernardes, Gonçalo J. L.
Knowles, T. P. J.
Paulo, Artur Cavaco
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Shimanovich, Ulyana
Bernardes, Gonçalo J. L.
Knowles, T. P. J.
Paulo, Artur Cavaco
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Micro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/28584
url http://hdl.handle.net/1822/28584
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chemical Society Reviews, 43(5), 1361-1371, 2014
0306-0012
10.1039/C3CS60376H
24336689
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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