Protein micro- and nano-capsules for biomedical applications
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/28584 |
Resumo: | Micro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules. |
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Protein micro- and nano-capsules for biomedical applicationsScience & TechnologyMicro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules.U.S. is grateful to Professor Aharon Gedanken, Chemistry Department, Bar-Ilan University, Israel, for his support and supervision during her PhD research work. G.J.L.B. is a Royal Society University Research Fellow at the Department of Chemistry, University of Cambridge and an Investigador FCT at the Instituto de Medicina Molecular, Lisboa. We thank Nuno Azoia assistance with the preparation of the figures. The authors thank the European Union Seventh Framework Programme (FP7/20072013) under grant agreement NMP4-LA-2009-228827 NANOFOL.Royal Society of ChemistryUniversidade do MinhoShimanovich, UlyanaBernardes, Gonçalo J. L.Knowles, T. P. J.Paulo, Artur Cavaco20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/28584engChemical Society Reviews, 43(5), 1361-1371, 20140306-001210.1039/C3CS60376H24336689info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:04:40Zoai:repositorium.sdum.uminho.pt:1822/28584Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:54:58.287729Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Protein micro- and nano-capsules for biomedical applications |
title |
Protein micro- and nano-capsules for biomedical applications |
spellingShingle |
Protein micro- and nano-capsules for biomedical applications Shimanovich, Ulyana Science & Technology |
title_short |
Protein micro- and nano-capsules for biomedical applications |
title_full |
Protein micro- and nano-capsules for biomedical applications |
title_fullStr |
Protein micro- and nano-capsules for biomedical applications |
title_full_unstemmed |
Protein micro- and nano-capsules for biomedical applications |
title_sort |
Protein micro- and nano-capsules for biomedical applications |
author |
Shimanovich, Ulyana |
author_facet |
Shimanovich, Ulyana Bernardes, Gonçalo J. L. Knowles, T. P. J. Paulo, Artur Cavaco |
author_role |
author |
author2 |
Bernardes, Gonçalo J. L. Knowles, T. P. J. Paulo, Artur Cavaco |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Shimanovich, Ulyana Bernardes, Gonçalo J. L. Knowles, T. P. J. Paulo, Artur Cavaco |
dc.subject.por.fl_str_mv |
Science & Technology |
topic |
Science & Technology |
description |
Micro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/28584 |
url |
http://hdl.handle.net/1822/28584 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemical Society Reviews, 43(5), 1361-1371, 2014 0306-0012 10.1039/C3CS60376H 24336689 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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