Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/153787 |
Resumo: | Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. |
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Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for CancerBio-availabilityCancer therapyClinical applicationsDrug-delivery systemsResveratrolResveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/153787eng2296-889X10.3389/fmolb.2021.649395Sharifi-Rad, JQuispe, CMukazhanova, ZKnut, ETurgumbayeva, AKipchakbayeva, ASeitimova, GMahomoodally, MFLobine, DKoay, AWang, JSheridan, HLeyva-Gómez, GPrado-Audelo, MLDCortes, HRescigno, AZucca, PSytar, OImran, MRodrigues, CFMartins, NEkiert, HKumar, MAbdull Razis, AFSunusi, UKamal, RMSzopa, Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:20:36Zoai:repositorio-aberto.up.pt:10216/153787Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:38:55.100506Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
spellingShingle |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer Sharifi-Rad, J Bio-availability Cancer therapy Clinical applications Drug-delivery systems Resveratrol |
title_short |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_full |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_fullStr |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_full_unstemmed |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_sort |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
author |
Sharifi-Rad, J |
author_facet |
Sharifi-Rad, J Quispe, C Mukazhanova, Z Knut, E Turgumbayeva, A Kipchakbayeva, A Seitimova, G Mahomoodally, MF Lobine, D Koay, A Wang, J Sheridan, H Leyva-Gómez, G Prado-Audelo, MLD Cortes, H Rescigno, A Zucca, P Sytar, O Imran, M Rodrigues, CF Martins, N Ekiert, H Kumar, M Abdull Razis, AF Sunusi, U Kamal, RM Szopa, A |
author_role |
author |
author2 |
Quispe, C Mukazhanova, Z Knut, E Turgumbayeva, A Kipchakbayeva, A Seitimova, G Mahomoodally, MF Lobine, D Koay, A Wang, J Sheridan, H Leyva-Gómez, G Prado-Audelo, MLD Cortes, H Rescigno, A Zucca, P Sytar, O Imran, M Rodrigues, CF Martins, N Ekiert, H Kumar, M Abdull Razis, AF Sunusi, U Kamal, RM Szopa, A |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sharifi-Rad, J Quispe, C Mukazhanova, Z Knut, E Turgumbayeva, A Kipchakbayeva, A Seitimova, G Mahomoodally, MF Lobine, D Koay, A Wang, J Sheridan, H Leyva-Gómez, G Prado-Audelo, MLD Cortes, H Rescigno, A Zucca, P Sytar, O Imran, M Rodrigues, CF Martins, N Ekiert, H Kumar, M Abdull Razis, AF Sunusi, U Kamal, RM Szopa, A |
dc.subject.por.fl_str_mv |
Bio-availability Cancer therapy Clinical applications Drug-delivery systems Resveratrol |
topic |
Bio-availability Cancer therapy Clinical applications Drug-delivery systems Resveratrol |
description |
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/153787 |
url |
https://hdl.handle.net/10216/153787 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2296-889X 10.3389/fmolb.2021.649395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135702778118144 |