Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50507 |
Resumo: | © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cellsAngiogenesisEndothelial CellFamilial Amyloidotic PolyneuropathyGene ExpressionMicroarrayTransthyretinVascular Biology© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.Familial amyloidotic polyneuropathy (FAP) has a high prevalence in Portugal, and the most common form of hereditary amyloidosis is caused by an amyloidogenic variant of transthyretin (TTR) with a substitution of methionine for valine at position 30 (V30M). Until now, the available efficient therapy is liver transplantation, when performed in an early phase of the onset of the disease symptoms. However, transplanted FAP patients have a significantly higher incidence of early hepatic artery thrombosis compared with non-FAP transplanted patients. Because FAP was described as an independent risk factor for early hepatic artery thrombosis, more studies to understand the underlying mechanisms involved in this outcome are of the utmost importance. Knowing that the liver is the major site for TTR production, we investigated the biological effects of TTR proteins in the vasculature and on angiogenesis. In this study, we identified genes differentially expressed in endothelial cells exposed to the WT or V30M tetramer. We found that endothelial cells may acquire different molecular identities when exposed to these proteins, and consequently TTR could regulate angiogenesis. Moreover, we show that V30M decreases endothelial survival by inducing apoptosis, and it inhibits migration. These findings provide new knowledge that may have critical implications in the prevention of early hepatic artery thrombosis in FAP patients after liver transplantation.This work was supported by Fundação para a Ciencia e Tecnologia Grant PIC/IC/83062/2007. Supported by Fundação para a Ciencia e Tecnologia (FCT) Fellowship SFRH/BPD/43482/2008.ElsevierRepositório da Universidade de LisboaNunes, Raquel J.de Oliveira, PaulaLages, AnaBecker, Jörg D.Marcelino, PauloBarroso, EduardoPerdigoto, RuiKelly, Jeffery W.Quintas, AlexandreSantos, Susana Constantino Rosa2021-12-21T16:50:07Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50507engJ Biol Chem. 2013 Nov 1;288(44):31752-600021-925810.1074/jbc.M113.4698581083-351Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:44Zoai:repositorio.ul.pt:10451/50507Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:57.487077Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
title |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
spellingShingle |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells Nunes, Raquel J. Angiogenesis Endothelial Cell Familial Amyloidotic Polyneuropathy Gene Expression Microarray Transthyretin Vascular Biology |
title_short |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
title_full |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
title_fullStr |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
title_full_unstemmed |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
title_sort |
Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells |
author |
Nunes, Raquel J. |
author_facet |
Nunes, Raquel J. de Oliveira, Paula Lages, Ana Becker, Jörg D. Marcelino, Paulo Barroso, Eduardo Perdigoto, Rui Kelly, Jeffery W. Quintas, Alexandre Santos, Susana Constantino Rosa |
author_role |
author |
author2 |
de Oliveira, Paula Lages, Ana Becker, Jörg D. Marcelino, Paulo Barroso, Eduardo Perdigoto, Rui Kelly, Jeffery W. Quintas, Alexandre Santos, Susana Constantino Rosa |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Nunes, Raquel J. de Oliveira, Paula Lages, Ana Becker, Jörg D. Marcelino, Paulo Barroso, Eduardo Perdigoto, Rui Kelly, Jeffery W. Quintas, Alexandre Santos, Susana Constantino Rosa |
dc.subject.por.fl_str_mv |
Angiogenesis Endothelial Cell Familial Amyloidotic Polyneuropathy Gene Expression Microarray Transthyretin Vascular Biology |
topic |
Angiogenesis Endothelial Cell Familial Amyloidotic Polyneuropathy Gene Expression Microarray Transthyretin Vascular Biology |
description |
© 2013 by The American Society for Biochemistry and Molecular Biology, Inc. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2021-12-21T16:50:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50507 |
url |
http://hdl.handle.net/10451/50507 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Biol Chem. 2013 Nov 1;288(44):31752-60 0021-9258 10.1074/jbc.M113.469858 1083-351X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134568587984896 |