Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/6945 |
Resumo: | "This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology." |
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7160 |
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Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial CellsAngiogenesisEndothelial CellFamilial Amyloidotic PolyneuropathyGene ExpressionMicroarrayTransthyretinVascular Biology"This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology.""Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."ASBMBRepositório ComumNunes, Raquel J.Oliveira, Paula deLages, AnaBecker, Jörg D.Marcelino, PauloBarroso, EduardoPerdigoto, RuiKelly, Jeffery W.Quintas, AlexandreSantos, Susana C. R.2014-11-06T14:20:47Z2013-11-012013-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/6945engTHE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 44, pp. 31752–31760, November 1, 20130021-925810.1074/jbc.M113.469858info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:30:55Zoai:comum.rcaap.pt:10400.26/6945Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:05.883748Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
title |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
spellingShingle |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells Nunes, Raquel J. Angiogenesis Endothelial Cell Familial Amyloidotic Polyneuropathy Gene Expression Microarray Transthyretin Vascular Biology |
title_short |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
title_full |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
title_fullStr |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
title_full_unstemmed |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
title_sort |
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells |
author |
Nunes, Raquel J. |
author_facet |
Nunes, Raquel J. Oliveira, Paula de Lages, Ana Becker, Jörg D. Marcelino, Paulo Barroso, Eduardo Perdigoto, Rui Kelly, Jeffery W. Quintas, Alexandre Santos, Susana C. R. |
author_role |
author |
author2 |
Oliveira, Paula de Lages, Ana Becker, Jörg D. Marcelino, Paulo Barroso, Eduardo Perdigoto, Rui Kelly, Jeffery W. Quintas, Alexandre Santos, Susana C. R. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Nunes, Raquel J. Oliveira, Paula de Lages, Ana Becker, Jörg D. Marcelino, Paulo Barroso, Eduardo Perdigoto, Rui Kelly, Jeffery W. Quintas, Alexandre Santos, Susana C. R. |
dc.subject.por.fl_str_mv |
Angiogenesis Endothelial Cell Familial Amyloidotic Polyneuropathy Gene Expression Microarray Transthyretin Vascular Biology |
topic |
Angiogenesis Endothelial Cell Familial Amyloidotic Polyneuropathy Gene Expression Microarray Transthyretin Vascular Biology |
description |
"This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology." |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-01 2013-11-01T00:00:00Z 2014-11-06T14:20:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/6945 |
url |
http://hdl.handle.net/10400.26/6945 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 44, pp. 31752–31760, November 1, 2013 0021-9258 10.1074/jbc.M113.469858 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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ASBMB |
publisher.none.fl_str_mv |
ASBMB |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129931461951488 |