Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2021000200023 |
Resumo: | Abstract Introduction: Clinical characteristics of Portuguese inpatients with coronavirus disease 2019 (COVID-19) are scarce. We aim to describe the demographic characteristics, clinical course and outcomes of hospitalized patients with COVID-19 and to analyze risk factors for in-hospital mortality. Material and Methods: Ambispective cohort study of adult COVID-19 patients admitted to a Portuguese tertiary hospital between March and August 2020. Asymptomatic, pregnant and all patients admitted due to social reasons were excluded. Results: Of the 432 admitted patients, 279 individuals were included. The median age was 69 years and 57% were male. The most common comorbidities were high blood pressure (66.3%), dyslipidemia (33.3%), diabetes (27.1%) and cardiovascular disease (CVD) (26.5%). The most common symptoms included fever (74.4%), cough (67.0%) and dyspnea (59.9%). Ferritin, C-reactive protein and D-dimer levels were elevated in 86.3%, 74.8% and 73.9% of patients, respectively. Mortality rate was 17.3%. 32.3% of the patients developed acute respiratory distress syndrome, 31.9% were admitted to intensive care unit and 20.8% were ventilated. In multivariable analysis, age (OR 1.04, 95% CI 1.01-1.09, p=0.023), CVD (OR 2.68, 95% CI 1.21-5.93, p=0.015) and lymphocyte count <0.5x109/L (OR 6.61, 95% CI 2.23-19.62, p=0.001) were risk factors for in-hospital mortality. Discussion: Our demographics, clinical and severity outcomes are in-line with international reports. Compared to other European countries, our less expressive in-hospital mortality rate might reflect a modestly controlled first outbreak in our country. Conclusion: This single-center study provides data on the clinical characteristics and outcomes of hospitalized patients with COVID-19 in Portugal. |
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Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in PortugalCOVID-19DemographyMortalityPortugalRisk FactorsSARS-CoV-2.Abstract Introduction: Clinical characteristics of Portuguese inpatients with coronavirus disease 2019 (COVID-19) are scarce. We aim to describe the demographic characteristics, clinical course and outcomes of hospitalized patients with COVID-19 and to analyze risk factors for in-hospital mortality. Material and Methods: Ambispective cohort study of adult COVID-19 patients admitted to a Portuguese tertiary hospital between March and August 2020. Asymptomatic, pregnant and all patients admitted due to social reasons were excluded. Results: Of the 432 admitted patients, 279 individuals were included. The median age was 69 years and 57% were male. The most common comorbidities were high blood pressure (66.3%), dyslipidemia (33.3%), diabetes (27.1%) and cardiovascular disease (CVD) (26.5%). The most common symptoms included fever (74.4%), cough (67.0%) and dyspnea (59.9%). Ferritin, C-reactive protein and D-dimer levels were elevated in 86.3%, 74.8% and 73.9% of patients, respectively. Mortality rate was 17.3%. 32.3% of the patients developed acute respiratory distress syndrome, 31.9% were admitted to intensive care unit and 20.8% were ventilated. In multivariable analysis, age (OR 1.04, 95% CI 1.01-1.09, p=0.023), CVD (OR 2.68, 95% CI 1.21-5.93, p=0.015) and lymphocyte count <0.5x109/L (OR 6.61, 95% CI 2.23-19.62, p=0.001) were risk factors for in-hospital mortality. Discussion: Our demographics, clinical and severity outcomes are in-line with international reports. Compared to other European countries, our less expressive in-hospital mortality rate might reflect a modestly controlled first outbreak in our country. Conclusion: This single-center study provides data on the clinical characteristics and outcomes of hospitalized patients with COVID-19 in Portugal.Sociedade Portuguesa de Medicina Interna2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2021000200023Medicina Interna v.28 n.2 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2021000200023Meireles,Pedro AntunesGaspar,PedroParreira,InêsAbrantes,Ana MafaldaSilva,Virgílio DiasBessa,FilipeLacerda,António Pais deMota,Catarinainfo:eu-repo/semantics/openAccess2024-02-06T17:08:32Zoai:scielo:S0872-671X2021000200023Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:53.971978Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
title |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
spellingShingle |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal Meireles,Pedro Antunes COVID-19 Demography Mortality Portugal Risk Factors SARS-CoV-2. |
title_short |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
title_full |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
title_fullStr |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
title_full_unstemmed |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
title_sort |
Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal |
author |
Meireles,Pedro Antunes |
author_facet |
Meireles,Pedro Antunes Gaspar,Pedro Parreira,Inês Abrantes,Ana Mafalda Silva,Virgílio Dias Bessa,Filipe Lacerda,António Pais de Mota,Catarina |
author_role |
author |
author2 |
Gaspar,Pedro Parreira,Inês Abrantes,Ana Mafalda Silva,Virgílio Dias Bessa,Filipe Lacerda,António Pais de Mota,Catarina |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Meireles,Pedro Antunes Gaspar,Pedro Parreira,Inês Abrantes,Ana Mafalda Silva,Virgílio Dias Bessa,Filipe Lacerda,António Pais de Mota,Catarina |
dc.subject.por.fl_str_mv |
COVID-19 Demography Mortality Portugal Risk Factors SARS-CoV-2. |
topic |
COVID-19 Demography Mortality Portugal Risk Factors SARS-CoV-2. |
description |
Abstract Introduction: Clinical characteristics of Portuguese inpatients with coronavirus disease 2019 (COVID-19) are scarce. We aim to describe the demographic characteristics, clinical course and outcomes of hospitalized patients with COVID-19 and to analyze risk factors for in-hospital mortality. Material and Methods: Ambispective cohort study of adult COVID-19 patients admitted to a Portuguese tertiary hospital between March and August 2020. Asymptomatic, pregnant and all patients admitted due to social reasons were excluded. Results: Of the 432 admitted patients, 279 individuals were included. The median age was 69 years and 57% were male. The most common comorbidities were high blood pressure (66.3%), dyslipidemia (33.3%), diabetes (27.1%) and cardiovascular disease (CVD) (26.5%). The most common symptoms included fever (74.4%), cough (67.0%) and dyspnea (59.9%). Ferritin, C-reactive protein and D-dimer levels were elevated in 86.3%, 74.8% and 73.9% of patients, respectively. Mortality rate was 17.3%. 32.3% of the patients developed acute respiratory distress syndrome, 31.9% were admitted to intensive care unit and 20.8% were ventilated. In multivariable analysis, age (OR 1.04, 95% CI 1.01-1.09, p=0.023), CVD (OR 2.68, 95% CI 1.21-5.93, p=0.015) and lymphocyte count <0.5x109/L (OR 6.61, 95% CI 2.23-19.62, p=0.001) were risk factors for in-hospital mortality. Discussion: Our demographics, clinical and severity outcomes are in-line with international reports. Compared to other European countries, our less expressive in-hospital mortality rate might reflect a modestly controlled first outbreak in our country. Conclusion: This single-center study provides data on the clinical characteristics and outcomes of hospitalized patients with COVID-19 in Portugal. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2021000200023 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2021000200023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2021000200023 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Interna |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Interna |
dc.source.none.fl_str_mv |
Medicina Interna v.28 n.2 2021 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137296043212800 |