Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/14952 |
Resumo: | PURPOSE We aimed to compare two different methods of region of interest (ROI) demarcation and determine interobserver variability on apparent diffusion coefficient (ADC) in breast lesions. METHODS Thirty-two patients with 39 lesions were evaluated with a 3.0 Tesla scanner using a diffusion-weighted sequence with several b-values. Two observers independently performed the ADC measurements using: 1) a small fixed area of 10 mm2 ROI within the area with highest restriction; 2) a large ROI so as to include the whole lesion. Differences were assessed using the Wilcoxon-rank test. Bland-Altman method and Spearman coefficient were applied for interobserver variability and correlation analysis. RESULTS ADC values measured using the two ROI demarcation methods were significantly different for both observers (P = 0.026; P = 0.033). There was no interobserver variability in ADC values using either method (large ROI, P = 0.21; small ROI, P = 0.64). ADC values of malignant lesions were significantly different between the two methods (P < 0.001). Variability in ADC was ≤0.008×10−3 mm2/s for both methods. When using the same method, ADC values were significantly correlated between the observers (small ROI: r=0.990, P < 0.001; large ROI: r=0.985, P < 0.001). CONCLUSION The choice of ROI demarcation method influences ADC measurements. Small ROIs show less overlap in ADC values and higher ADC reproducibility, suggesting that this method may improve lesion discrimination. Interobserver variability was low for both methods. |
id |
RCAP_31735ef1b38ead200a1a13069a49cd1d |
---|---|
oai_identifier_str |
oai:recipp.ipp.pt:10400.22/14952 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variabilityBreast NeoplasmsDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingImage Interpretation, Computer-AssistedMiddle AgedObserver VariationReproducibility of ResultsPURPOSE We aimed to compare two different methods of region of interest (ROI) demarcation and determine interobserver variability on apparent diffusion coefficient (ADC) in breast lesions. METHODS Thirty-two patients with 39 lesions were evaluated with a 3.0 Tesla scanner using a diffusion-weighted sequence with several b-values. Two observers independently performed the ADC measurements using: 1) a small fixed area of 10 mm2 ROI within the area with highest restriction; 2) a large ROI so as to include the whole lesion. Differences were assessed using the Wilcoxon-rank test. Bland-Altman method and Spearman coefficient were applied for interobserver variability and correlation analysis. RESULTS ADC values measured using the two ROI demarcation methods were significantly different for both observers (P = 0.026; P = 0.033). There was no interobserver variability in ADC values using either method (large ROI, P = 0.21; small ROI, P = 0.64). ADC values of malignant lesions were significantly different between the two methods (P < 0.001). Variability in ADC was ≤0.008×10−3 mm2/s for both methods. When using the same method, ADC values were significantly correlated between the observers (small ROI: r=0.990, P < 0.001; large ROI: r=0.985, P < 0.001). CONCLUSION The choice of ROI demarcation method influences ADC measurements. Small ROIs show less overlap in ADC values and higher ADC reproducibility, suggesting that this method may improve lesion discrimination. Interobserver variability was low for both methods.Repositório Científico do Instituto Politécnico do PortoNogueira, LuísaBrandão, SofiaMatos, EduardaNunes, Rita GouveiaFerreira, Hugo AlexandreLoureiro, JoanaRamos, Isabel2019-11-26T13:45:41Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14952eng10.5152/dir.2014.14217info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:58:39Zoai:recipp.ipp.pt:10400.22/14952Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:45.254907Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
title |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
spellingShingle |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability Nogueira, Luísa Breast Neoplasms Diagnosis, Differential Diffusion Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Middle Aged Observer Variation Reproducibility of Results |
title_short |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
title_full |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
title_fullStr |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
title_full_unstemmed |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
title_sort |
Region of interest demarcation for quantification of the apparent diffusion coefficient in breast lesions and its interobserver variability |
author |
Nogueira, Luísa |
author_facet |
Nogueira, Luísa Brandão, Sofia Matos, Eduarda Nunes, Rita Gouveia Ferreira, Hugo Alexandre Loureiro, Joana Ramos, Isabel |
author_role |
author |
author2 |
Brandão, Sofia Matos, Eduarda Nunes, Rita Gouveia Ferreira, Hugo Alexandre Loureiro, Joana Ramos, Isabel |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Nogueira, Luísa Brandão, Sofia Matos, Eduarda Nunes, Rita Gouveia Ferreira, Hugo Alexandre Loureiro, Joana Ramos, Isabel |
dc.subject.por.fl_str_mv |
Breast Neoplasms Diagnosis, Differential Diffusion Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Middle Aged Observer Variation Reproducibility of Results |
topic |
Breast Neoplasms Diagnosis, Differential Diffusion Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Middle Aged Observer Variation Reproducibility of Results |
description |
PURPOSE We aimed to compare two different methods of region of interest (ROI) demarcation and determine interobserver variability on apparent diffusion coefficient (ADC) in breast lesions. METHODS Thirty-two patients with 39 lesions were evaluated with a 3.0 Tesla scanner using a diffusion-weighted sequence with several b-values. Two observers independently performed the ADC measurements using: 1) a small fixed area of 10 mm2 ROI within the area with highest restriction; 2) a large ROI so as to include the whole lesion. Differences were assessed using the Wilcoxon-rank test. Bland-Altman method and Spearman coefficient were applied for interobserver variability and correlation analysis. RESULTS ADC values measured using the two ROI demarcation methods were significantly different for both observers (P = 0.026; P = 0.033). There was no interobserver variability in ADC values using either method (large ROI, P = 0.21; small ROI, P = 0.64). ADC values of malignant lesions were significantly different between the two methods (P < 0.001). Variability in ADC was ≤0.008×10−3 mm2/s for both methods. When using the same method, ADC values were significantly correlated between the observers (small ROI: r=0.990, P < 0.001; large ROI: r=0.985, P < 0.001). CONCLUSION The choice of ROI demarcation method influences ADC measurements. Small ROIs show less overlap in ADC values and higher ADC reproducibility, suggesting that this method may improve lesion discrimination. Interobserver variability was low for both methods. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z 2019-11-26T13:45:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/14952 |
url |
http://hdl.handle.net/10400.22/14952 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5152/dir.2014.14217 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131439720038400 |