Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/40051 |
Resumo: | The growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testosterone exposure has become an important tool to study prostatic carcinogenesis and chemopreventive approaches. Over prolonged treatment, this model develops prostatic lesions that closely mimic those observed in human patients. By modifying the experimental conditions, different research groups have been able to induce a vast spectrum of lesions, ranging from early prostatic intraepithelial neoplasia to metastatic cancer. These carefully tuned experimental settings allowed researchers to test lifestyle interventions, and different pharmacological and chemopreventive strategies. However, this model's great flexibility requires careful planning to ensure that the experimental conditions are adequate to obtain the spectrum of lesions intended. The present review addresses such issues, highlighting the value of the rat prostate cancer model and the multiple challenges and opportunities it offers to researchers worldwide. |
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Appraising Animal Models of Prostate Cancer for Translational Research: Future DirectionsAnimal modelsProstate cancerReviewThe growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testosterone exposure has become an important tool to study prostatic carcinogenesis and chemopreventive approaches. Over prolonged treatment, this model develops prostatic lesions that closely mimic those observed in human patients. By modifying the experimental conditions, different research groups have been able to induce a vast spectrum of lesions, ranging from early prostatic intraepithelial neoplasia to metastatic cancer. These carefully tuned experimental settings allowed researchers to test lifestyle interventions, and different pharmacological and chemopreventive strategies. However, this model's great flexibility requires careful planning to ensure that the experimental conditions are adequate to obtain the spectrum of lesions intended. The present review addresses such issues, highlighting the value of the rat prostate cancer model and the multiple challenges and opportunities it offers to researchers worldwide.International Institute of Anticancer Research2024-01-10T16:31:57Z2023-01-01T00:00:00Z2023-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/40051eng0250-700510.21873/anticanres.16160Nascimento Gonçalves, ElisabeteSeixas, FernandaDa Costa, Rui M. GilPires, Maria JoaoNeuparth, Maria JoaoMoreira-Goncalves, DanielFardilha, MargaridaFaustino-Rocha, Ana I.Colaco, BrunoFerreira, RitaOliveira, Paula A.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:18:14Zoai:ria.ua.pt:10773/40051Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:10:04.647628Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
title |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
spellingShingle |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions Nascimento Gonçalves, Elisabete Animal models Prostate cancer Review |
title_short |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
title_full |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
title_fullStr |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
title_full_unstemmed |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
title_sort |
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions |
author |
Nascimento Gonçalves, Elisabete |
author_facet |
Nascimento Gonçalves, Elisabete Seixas, Fernanda Da Costa, Rui M. Gil Pires, Maria Joao Neuparth, Maria Joao Moreira-Goncalves, Daniel Fardilha, Margarida Faustino-Rocha, Ana I. Colaco, Bruno Ferreira, Rita Oliveira, Paula A. |
author_role |
author |
author2 |
Seixas, Fernanda Da Costa, Rui M. Gil Pires, Maria Joao Neuparth, Maria Joao Moreira-Goncalves, Daniel Fardilha, Margarida Faustino-Rocha, Ana I. Colaco, Bruno Ferreira, Rita Oliveira, Paula A. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento Gonçalves, Elisabete Seixas, Fernanda Da Costa, Rui M. Gil Pires, Maria Joao Neuparth, Maria Joao Moreira-Goncalves, Daniel Fardilha, Margarida Faustino-Rocha, Ana I. Colaco, Bruno Ferreira, Rita Oliveira, Paula A. |
dc.subject.por.fl_str_mv |
Animal models Prostate cancer Review |
topic |
Animal models Prostate cancer Review |
description |
The growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testosterone exposure has become an important tool to study prostatic carcinogenesis and chemopreventive approaches. Over prolonged treatment, this model develops prostatic lesions that closely mimic those observed in human patients. By modifying the experimental conditions, different research groups have been able to induce a vast spectrum of lesions, ranging from early prostatic intraepithelial neoplasia to metastatic cancer. These carefully tuned experimental settings allowed researchers to test lifestyle interventions, and different pharmacological and chemopreventive strategies. However, this model's great flexibility requires careful planning to ensure that the experimental conditions are adequate to obtain the spectrum of lesions intended. The present review addresses such issues, highlighting the value of the rat prostate cancer model and the multiple challenges and opportunities it offers to researchers worldwide. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-01T00:00:00Z 2023-01 2024-01-10T16:31:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/40051 |
url |
http://hdl.handle.net/10773/40051 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0250-7005 10.21873/anticanres.16160 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
International Institute of Anticancer Research |
publisher.none.fl_str_mv |
International Institute of Anticancer Research |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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