A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/64610 |
Resumo: | Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnetite at 50 °C was found to produce an interaction reaction between the ester groups of the PLLA and the metallic cations of the magnetite, causing the formation of complexes. This fact was confirmed by the analysis of the infrared spectroscopy and the gel permeation chromatography test results. They, respectively, showed a displacement of the absorption bands of the carbonyl group (C=O) of the PLLA and a scission of the polymer chains. The iron from the magnetite acted as a catalyser of the macromolecular scission reaction, which determines the final biomedical applications of the scaffolds—it does so because the reaction shortens the degradation process without appearing to influence its toxicity. None of the samples studied in the tests presented cytotoxicity, even at 70% magnetite concentrations. |
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A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffoldspolymer scissionPLLAmagnetitecytotoxicitymagnetismin vitro degradationScience & TechnologyMagnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnetite at 50 °C was found to produce an interaction reaction between the ester groups of the PLLA and the metallic cations of the magnetite, causing the formation of complexes. This fact was confirmed by the analysis of the infrared spectroscopy and the gel permeation chromatography test results. They, respectively, showed a displacement of the absorption bands of the carbonyl group (C=O) of the PLLA and a scission of the polymer chains. The iron from the magnetite acted as a catalyser of the macromolecular scission reaction, which determines the final biomedical applications of the scaffolds—it does so because the reaction shortens the degradation process without appearing to influence its toxicity. None of the samples studied in the tests presented cytotoxicity, even at 70% magnetite concentrations.This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoDíaz, E.Valle, M. B.Ribeiro, Sylvie OliveiraLanceros-Méndez, S.Barandiarán, J. M.20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/64610engDíaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros‑Mendez, S.; Barandiarán, J.M. A New Approach for the Fabrication of Cytocompatible PLLA-Magnetite Nanoparticle Composite Scaffolds. Int. J. Mol. Sci. 2019, 20, 4664.1661-65961422-006710.3390/ijms2019466431547060https://www.mdpi.com/1422-0067/20/19/4664info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:45Zoai:repositorium.sdum.uminho.pt:1822/64610Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:29.449567Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
title |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
spellingShingle |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds Díaz, E. polymer scission PLLA magnetite cytotoxicity magnetism in vitro degradation Science & Technology |
title_short |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
title_full |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
title_fullStr |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
title_full_unstemmed |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
title_sort |
A new approach for the fabrication of cytocompatible PLLA-magnetite nanoparticle composite scaffolds |
author |
Díaz, E. |
author_facet |
Díaz, E. Valle, M. B. Ribeiro, Sylvie Oliveira Lanceros-Méndez, S. Barandiarán, J. M. |
author_role |
author |
author2 |
Valle, M. B. Ribeiro, Sylvie Oliveira Lanceros-Méndez, S. Barandiarán, J. M. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Díaz, E. Valle, M. B. Ribeiro, Sylvie Oliveira Lanceros-Méndez, S. Barandiarán, J. M. |
dc.subject.por.fl_str_mv |
polymer scission PLLA magnetite cytotoxicity magnetism in vitro degradation Science & Technology |
topic |
polymer scission PLLA magnetite cytotoxicity magnetism in vitro degradation Science & Technology |
description |
Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnetite at 50 °C was found to produce an interaction reaction between the ester groups of the PLLA and the metallic cations of the magnetite, causing the formation of complexes. This fact was confirmed by the analysis of the infrared spectroscopy and the gel permeation chromatography test results. They, respectively, showed a displacement of the absorption bands of the carbonyl group (C=O) of the PLLA and a scission of the polymer chains. The iron from the magnetite acted as a catalyser of the macromolecular scission reaction, which determines the final biomedical applications of the scaffolds—it does so because the reaction shortens the degradation process without appearing to influence its toxicity. None of the samples studied in the tests presented cytotoxicity, even at 70% magnetite concentrations. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/64610 |
url |
http://hdl.handle.net/1822/64610 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Díaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros‑Mendez, S.; Barandiarán, J.M. A New Approach for the Fabrication of Cytocompatible PLLA-Magnetite Nanoparticle Composite Scaffolds. Int. J. Mol. Sci. 2019, 20, 4664. 1661-6596 1422-0067 10.3390/ijms20194664 31547060 https://www.mdpi.com/1422-0067/20/19/4664 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132809762177024 |