Vimentin diversity in health and disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.13/4424 |
Resumo: | Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn’s disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives. |
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Vimentin diversity in health and diseaseVimentinIntermediate filamentsCell-extracellular matrix adhesionsExtracellular vimentinCell mechanical stiffness or elasticityCellular contractilityBiomechanicsEpithelial-mesenchymal transitionTissue regenerationCancer and metastasisDrug targetClinical biomarkers.Faculdade de Ciências da VidaVimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn’s disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives.MDPIDigitUMaDanielsson, FridaPeterson, McKenzieAraújo, Helena CaldeiraLautenschläger, FranziskaGad, Annica Karin Britt2022-07-19T11:04:12Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/4424engDanielsson, F., Peterson, M. K., Araújo, H. C., Lautenschläger, F., & Gad, A. K. B. (2018). Vimentin diversity in health and disease. Cells, 7(10), 147.10.3390/cells7100147info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-19T05:37:00Zoai:digituma.uma.pt:10400.13/4424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:27.459979Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Vimentin diversity in health and disease |
title |
Vimentin diversity in health and disease |
spellingShingle |
Vimentin diversity in health and disease Danielsson, Frida Vimentin Intermediate filaments Cell-extracellular matrix adhesions Extracellular vimentin Cell mechanical stiffness or elasticity Cellular contractility Biomechanics Epithelial-mesenchymal transition Tissue regeneration Cancer and metastasis Drug target Clinical biomarkers . Faculdade de Ciências da Vida |
title_short |
Vimentin diversity in health and disease |
title_full |
Vimentin diversity in health and disease |
title_fullStr |
Vimentin diversity in health and disease |
title_full_unstemmed |
Vimentin diversity in health and disease |
title_sort |
Vimentin diversity in health and disease |
author |
Danielsson, Frida |
author_facet |
Danielsson, Frida Peterson, McKenzie Araújo, Helena Caldeira Lautenschläger, Franziska Gad, Annica Karin Britt |
author_role |
author |
author2 |
Peterson, McKenzie Araújo, Helena Caldeira Lautenschläger, Franziska Gad, Annica Karin Britt |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
DigitUMa |
dc.contributor.author.fl_str_mv |
Danielsson, Frida Peterson, McKenzie Araújo, Helena Caldeira Lautenschläger, Franziska Gad, Annica Karin Britt |
dc.subject.por.fl_str_mv |
Vimentin Intermediate filaments Cell-extracellular matrix adhesions Extracellular vimentin Cell mechanical stiffness or elasticity Cellular contractility Biomechanics Epithelial-mesenchymal transition Tissue regeneration Cancer and metastasis Drug target Clinical biomarkers . Faculdade de Ciências da Vida |
topic |
Vimentin Intermediate filaments Cell-extracellular matrix adhesions Extracellular vimentin Cell mechanical stiffness or elasticity Cellular contractility Biomechanics Epithelial-mesenchymal transition Tissue regeneration Cancer and metastasis Drug target Clinical biomarkers . Faculdade de Ciências da Vida |
description |
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn’s disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2022-07-19T11:04:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.13/4424 |
url |
http://hdl.handle.net/10400.13/4424 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Danielsson, F., Peterson, M. K., Araújo, H. C., Lautenschläger, F., & Gad, A. K. B. (2018). Vimentin diversity in health and disease. Cells, 7(10), 147. 10.3390/cells7100147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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