Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties

Detalhes bibliográficos
Autor(a) principal: Mesquita, Rui
Data de Publicação: 2001
Outros Autores: Pires, Ivo, Saldanha, Carlota, Martins-Silva, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/20162
Resumo: © 2001 – IOS Press. All rights reserved
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spelling Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties© 2001 – IOS Press. All rights reservedPurpose of the study: To determine the effects of acetylcholine and SpermineNONOate – a NO donor – on RBC membrane and oxygen carrying properties. Material and methods: Aliquots of venous blood from eleven heathy subjects were incubated with ACh 10−3 M, ACh 10−5 M, SpermineNONOate 10−5 M and SpermineNONOate 10−4 M. The following parameters were determined: erythrocyte aggregation and deformability, hematocrit, plasma pH, osmolality, K+, Na+, Ca2+ concentrations, hemoglobin, oxyhemoglobin, carboxihemoglobin and methemoglobin concentrations, oxygen saturation of hemoglobin, oxygen and carbon dioxide parcial pressures and p50. Results: In presence of ACh there is an increase of erythrocyte deformability, decrease of erythrocyte aggregation, plasma pH, K+ and Na+ concentration, increase of Ca2+ concentration and p50. In presence of SpermineNONOate there an increase of erythrocyte deformability, plasma pH, decrease of Na+ and Ca2+ concentration, increase of metHb concentration and decrease of p50. Conclusion: Acetylcholine and SpermineNONOate are able to induce changes on RBC membrane and oxygen carrying properties.IOS PressRepositório da Universidade de LisboaMesquita, RuiPires, IvoSaldanha, CarlotaMartins-Silva, João2015-09-29T14:21:11Z20012001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/20162engClinical Hemorheology and Microcirculation 25 (2001) 153–1631386-0291http://content.iospress.com/journals/clinical-hemorheology-and-microcirculation/25/3,4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:05:22Zoai:repositorio.ul.pt:10451/20162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:38:16.014134Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
title Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
spellingShingle Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
Mesquita, Rui
title_short Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
title_full Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
title_fullStr Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
title_full_unstemmed Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
title_sort Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
author Mesquita, Rui
author_facet Mesquita, Rui
Pires, Ivo
Saldanha, Carlota
Martins-Silva, João
author_role author
author2 Pires, Ivo
Saldanha, Carlota
Martins-Silva, João
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mesquita, Rui
Pires, Ivo
Saldanha, Carlota
Martins-Silva, João
description © 2001 – IOS Press. All rights reserved
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01T00:00:00Z
2015-09-29T14:21:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/20162
url http://hdl.handle.net/10451/20162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 25 (2001) 153–163
1386-0291
http://content.iospress.com/journals/clinical-hemorheology-and-microcirculation/25/3,4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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