Ethanol and erythrocyte membrane interaction : a hemorheologic perspective

Detalhes bibliográficos
Autor(a) principal: Mesquita, R.
Data de Publicação: 1999
Outros Autores: Gonçalves, M. I., Dias, S., Sargento, L., Saldanha, C., Martins e Silva, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/17891
Resumo: © 1999 – IOS Press. All rights reserved
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spelling Ethanol and erythrocyte membrane interaction : a hemorheologic perspective© 1999 – IOS Press. All rights reservedPrevious studies have documented structural and functional changes induced by ethanol–erythrocyte membrane interaction. In order to perform an in vitro study on the effect of different ethanol concentrations on erythrocyte hemorheologic properties, blood samples were collected from 21 male donors at the Hospital of Santa Maria. Whole blood aliquots were incubated with ethanol solutions of rising concentrations. The following parameters were measured: erythrocyte aggregation, haemoglobin, carboxyhaemoglobin and methaemoglobin concentrations, hematocrit, plasma osmolality and erythrocyte membrane fluidity (fluorescence polarisation probes TMA-DPH and DPH). With ethanol blood concentrations of 45 mM a rise in plasma osmolality (0.352 Osm/kg H2O vs 0.310 Osm/kg H2O; p < 0.001) was verified. With 67 mM concentration a decrease of erythrocyte aggregation (11.03 vs 12.81; p < 0.05) and an increase in plasma osmolality (0.380 Osm/kg H2O vs 0.310 Osm/kg H2O;p < 0.001) were obtained. In conclusion, ethanol only changes erythrocyte aggregation for a concentration of 67 mM. These data could lead to future changes in therapeutic approaches to situations such as alcoholic coma.IOS PressRepositório da Universidade de LisboaMesquita, R.Gonçalves, M. I.Dias, S.Sargento, L.Saldanha, C.Martins e Silva, J.2015-04-14T10:26:47Z19991999-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17891engClinical Hemorheology and Microcirculation 21 (1999) 95–981386-0291http://iospress.metapress.com/content/455nmpjftq4ybkj7/?p=4d7a0fdd1d23412eabfc243594816b78&pi=2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:47Zoai:repositorio.ul.pt:10451/17891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:36.689269Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
title Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
spellingShingle Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
Mesquita, R.
title_short Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
title_full Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
title_fullStr Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
title_full_unstemmed Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
title_sort Ethanol and erythrocyte membrane interaction : a hemorheologic perspective
author Mesquita, R.
author_facet Mesquita, R.
Gonçalves, M. I.
Dias, S.
Sargento, L.
Saldanha, C.
Martins e Silva, J.
author_role author
author2 Gonçalves, M. I.
Dias, S.
Sargento, L.
Saldanha, C.
Martins e Silva, J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mesquita, R.
Gonçalves, M. I.
Dias, S.
Sargento, L.
Saldanha, C.
Martins e Silva, J.
description © 1999 – IOS Press. All rights reserved
publishDate 1999
dc.date.none.fl_str_mv 1999
1999-01-01T00:00:00Z
2015-04-14T10:26:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/17891
url http://hdl.handle.net/10451/17891
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 21 (1999) 95–98
1386-0291
http://iospress.metapress.com/content/455nmpjftq4ybkj7/?p=4d7a0fdd1d23412eabfc243594816b78&pi=2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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