A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/24356 |
Resumo: | Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brainmachine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closedloop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders. |
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A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulationAlthough electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brainmachine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closedloop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.NatureVeritati - Repositório Institucional da Universidade Católica PortuguesaPais-Vieira, MiguelYadav, Amol P.Moreira, DerekGuggenmos, DavidSantos, AmílcarLebedev, MikhailNicolelis, Miguel A. L.2018-05-24T14:02:42Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/24356engPAIS-VIEIRA, Miguel; YADAV, Amol P.; MOREIRA, Derek; GUGGENMOS, David; SANTOS, Amílcar; LEBEDEV, Mikhail; NICOLELIS, Miguel A. L. - A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific Report. ISSN 2045-2322. N.º 6: 32814 (2016), 9 p.2045-232210.1038/srep32814000382643600001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:27:32Zoai:repositorio.ucp.pt:10400.14/24356Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:17:47.570814Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
title |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
spellingShingle |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation Pais-Vieira, Miguel |
title_short |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
title_full |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
title_fullStr |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
title_full_unstemmed |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
title_sort |
A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation |
author |
Pais-Vieira, Miguel |
author_facet |
Pais-Vieira, Miguel Yadav, Amol P. Moreira, Derek Guggenmos, David Santos, Amílcar Lebedev, Mikhail Nicolelis, Miguel A. L. |
author_role |
author |
author2 |
Yadav, Amol P. Moreira, Derek Guggenmos, David Santos, Amílcar Lebedev, Mikhail Nicolelis, Miguel A. L. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Pais-Vieira, Miguel Yadav, Amol P. Moreira, Derek Guggenmos, David Santos, Amílcar Lebedev, Mikhail Nicolelis, Miguel A. L. |
description |
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brainmachine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closedloop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z 2018-05-24T14:02:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/24356 |
url |
http://hdl.handle.net/10400.14/24356 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PAIS-VIEIRA, Miguel; YADAV, Amol P.; MOREIRA, Derek; GUGGENMOS, David; SANTOS, Amílcar; LEBEDEV, Mikhail; NICOLELIS, Miguel A. L. - A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific Report. ISSN 2045-2322. N.º 6: 32814 (2016), 9 p. 2045-2322 10.1038/srep32814 000382643600001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature |
publisher.none.fl_str_mv |
Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131866229374976 |