Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents

Detalhes bibliográficos
Autor(a) principal: Diana O. Silva
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/65531
Resumo: "Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"
id RCAP_32f36dd271ab773ea2ac2cc14ff50ab2
oai_identifier_str oai:run.unl.pt:10362/65531
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agentsHDACiChemical SynthesisBiochemistry"Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"Ventura, RitaRUNDiana O. Silva2019-04-04T15:36:44Z20162016-112016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/65531enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:31:15Zoai:run.unl.pt:10362/65531Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:34:22.716171Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
spellingShingle Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
Diana O. Silva
HDACi
Chemical Synthesis
Biochemistry
title_short Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_full Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_fullStr Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_full_unstemmed Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_sort Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
author Diana O. Silva
author_facet Diana O. Silva
author_role author
dc.contributor.none.fl_str_mv Ventura, Rita
RUN
dc.contributor.author.fl_str_mv Diana O. Silva
dc.subject.por.fl_str_mv HDACi
Chemical Synthesis
Biochemistry
topic HDACi
Chemical Synthesis
Biochemistry
description "Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-11
2016-01-01T00:00:00Z
2019-04-04T15:36:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/65531
url http://hdl.handle.net/10362/65531
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137965385973760

Registros relacionados