Non-Coding RNAs : multi-tasking molecules in the cell

Detalhes bibliográficos
Autor(a) principal: Gomes, Anita Quintal
Data de Publicação: 2013
Outros Autores: Nolasco, Sofia, Soares, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/7218
Resumo: Articles in International Journals
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spelling Non-Coding RNAs : multi-tasking molecules in the cellsncRNAslncRNAsmiRNAssiRNAspiRNAsgene expression regulationepigenetic regulationArticles in International JournalsIn the last years it has become increasingly clear that the mammalian transcriptome is highly complex and includes a large number of small non-coding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs). Here we review the biogenesis pathways of the three classes of sncRNAs, namely short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). These ncRNAs have been extensively studied and are involved in pathways leading to specific gene silencing and the protection of genomes against virus and transposons, for example. Also, lncRNAs have emerged as pivotal molecules for the transcriptional and post-transcriptional regulation of gene expression which is supported by their tissue-specific expression patterns, subcellular distribution, and developmental regulation. Therefore, we also focus our attention on their role in differentiation and development. SncRNAs and lncRNAs play critical roles in defining DNA methylation patterns, as well as chromatin remodeling thus having a substantial effect in epigenetics. The identification of some overlaps in their biogenesis pathways and functional roles raises the hypothesis that these molecules play concerted functions in vivo, creating complex regulatory networks where cooperation with regulatory proteins is necessary. We also highlighted the implications of biogenesis and gene expression deregulation of sncRNAs and lncRNAs in human diseases like cancer.International Journal of Molecular SciencesRepositório da Universidade de LisboaGomes, Anita QuintalNolasco, SofiaSoares, Helena2014-09-26T10:54:47Z2013-07-312013-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7218engGomes, A. Q., Nolasco, S., Soares, H. (2013). Non-Coding RNAs : multi-tasking molecules in the cell. International Journal of Molecular Sciences, 14(8),16010-16039. doi:10.3390/ijms1408160101422-0067 (online)10.3390/ijms140816010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:37:57Zoai:www.repository.utl.pt:10400.5/7218Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:54:26.430740Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Non-Coding RNAs : multi-tasking molecules in the cell
title Non-Coding RNAs : multi-tasking molecules in the cell
spellingShingle Non-Coding RNAs : multi-tasking molecules in the cell
Gomes, Anita Quintal
sncRNAs
lncRNAs
miRNAs
siRNAs
piRNAs
gene expression regulation
epigenetic regulation
title_short Non-Coding RNAs : multi-tasking molecules in the cell
title_full Non-Coding RNAs : multi-tasking molecules in the cell
title_fullStr Non-Coding RNAs : multi-tasking molecules in the cell
title_full_unstemmed Non-Coding RNAs : multi-tasking molecules in the cell
title_sort Non-Coding RNAs : multi-tasking molecules in the cell
author Gomes, Anita Quintal
author_facet Gomes, Anita Quintal
Nolasco, Sofia
Soares, Helena
author_role author
author2 Nolasco, Sofia
Soares, Helena
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes, Anita Quintal
Nolasco, Sofia
Soares, Helena
dc.subject.por.fl_str_mv sncRNAs
lncRNAs
miRNAs
siRNAs
piRNAs
gene expression regulation
epigenetic regulation
topic sncRNAs
lncRNAs
miRNAs
siRNAs
piRNAs
gene expression regulation
epigenetic regulation
description Articles in International Journals
publishDate 2013
dc.date.none.fl_str_mv 2013-07-31
2013-07-31T00:00:00Z
2014-09-26T10:54:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/7218
url http://hdl.handle.net/10400.5/7218
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes, A. Q., Nolasco, S., Soares, H. (2013). Non-Coding RNAs : multi-tasking molecules in the cell. International Journal of Molecular Sciences, 14(8),16010-16039. doi:10.3390/ijms140816010
1422-0067 (online)
10.3390/ijms140816010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Journal of Molecular Sciences
publisher.none.fl_str_mv International Journal of Molecular Sciences
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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