Non-Coding RNAs : multi-tasking molecules in the cell
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/7218 |
Resumo: | Articles in International Journals |
id |
RCAP_338d75a0e85f2d5ae244e496665c208f |
---|---|
oai_identifier_str |
oai:www.repository.utl.pt:10400.5/7218 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Non-Coding RNAs : multi-tasking molecules in the cellsncRNAslncRNAsmiRNAssiRNAspiRNAsgene expression regulationepigenetic regulationArticles in International JournalsIn the last years it has become increasingly clear that the mammalian transcriptome is highly complex and includes a large number of small non-coding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs). Here we review the biogenesis pathways of the three classes of sncRNAs, namely short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). These ncRNAs have been extensively studied and are involved in pathways leading to specific gene silencing and the protection of genomes against virus and transposons, for example. Also, lncRNAs have emerged as pivotal molecules for the transcriptional and post-transcriptional regulation of gene expression which is supported by their tissue-specific expression patterns, subcellular distribution, and developmental regulation. Therefore, we also focus our attention on their role in differentiation and development. SncRNAs and lncRNAs play critical roles in defining DNA methylation patterns, as well as chromatin remodeling thus having a substantial effect in epigenetics. The identification of some overlaps in their biogenesis pathways and functional roles raises the hypothesis that these molecules play concerted functions in vivo, creating complex regulatory networks where cooperation with regulatory proteins is necessary. We also highlighted the implications of biogenesis and gene expression deregulation of sncRNAs and lncRNAs in human diseases like cancer.International Journal of Molecular SciencesRepositório da Universidade de LisboaGomes, Anita QuintalNolasco, SofiaSoares, Helena2014-09-26T10:54:47Z2013-07-312013-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7218engGomes, A. Q., Nolasco, S., Soares, H. (2013). Non-Coding RNAs : multi-tasking molecules in the cell. International Journal of Molecular Sciences, 14(8),16010-16039. doi:10.3390/ijms1408160101422-0067 (online)10.3390/ijms140816010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:37:57Zoai:www.repository.utl.pt:10400.5/7218Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:54:26.430740Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Non-Coding RNAs : multi-tasking molecules in the cell |
title |
Non-Coding RNAs : multi-tasking molecules in the cell |
spellingShingle |
Non-Coding RNAs : multi-tasking molecules in the cell Gomes, Anita Quintal sncRNAs lncRNAs miRNAs siRNAs piRNAs gene expression regulation epigenetic regulation |
title_short |
Non-Coding RNAs : multi-tasking molecules in the cell |
title_full |
Non-Coding RNAs : multi-tasking molecules in the cell |
title_fullStr |
Non-Coding RNAs : multi-tasking molecules in the cell |
title_full_unstemmed |
Non-Coding RNAs : multi-tasking molecules in the cell |
title_sort |
Non-Coding RNAs : multi-tasking molecules in the cell |
author |
Gomes, Anita Quintal |
author_facet |
Gomes, Anita Quintal Nolasco, Sofia Soares, Helena |
author_role |
author |
author2 |
Nolasco, Sofia Soares, Helena |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Gomes, Anita Quintal Nolasco, Sofia Soares, Helena |
dc.subject.por.fl_str_mv |
sncRNAs lncRNAs miRNAs siRNAs piRNAs gene expression regulation epigenetic regulation |
topic |
sncRNAs lncRNAs miRNAs siRNAs piRNAs gene expression regulation epigenetic regulation |
description |
Articles in International Journals |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07-31 2013-07-31T00:00:00Z 2014-09-26T10:54:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/7218 |
url |
http://hdl.handle.net/10400.5/7218 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gomes, A. Q., Nolasco, S., Soares, H. (2013). Non-Coding RNAs : multi-tasking molecules in the cell. International Journal of Molecular Sciences, 14(8),16010-16039. doi:10.3390/ijms140816010 1422-0067 (online) 10.3390/ijms140816010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
International Journal of Molecular Sciences |
publisher.none.fl_str_mv |
International Journal of Molecular Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131020747866112 |