Accuracy of the new rapid test for monitoring adalimumab levels

Detalhes bibliográficos
Autor(a) principal: Rocha, C
Data de Publicação: 2019
Outros Autores: Afonso, J, Lago, P, Arroja, B, Vieira, AI, Dias, CC, Magro, F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/1323
Resumo: The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available rapid-test ADL quantification assay by comparing it with three established ELISA methods, using spiked samples and a set of clinical samples.
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spelling Accuracy of the new rapid test for monitoring adalimumab levelsAdalimumabThe loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available rapid-test ADL quantification assay by comparing it with three established ELISA methods, using spiked samples and a set of clinical samples.Repositório Científico do Hospital de BragaRocha, CAfonso, JLago, PArroja, BVieira, AIDias, CCMagro, F2019-05-16T12:44:42Z2019-01-01T00:00:00Z2019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1323engTherap Adv Gastroenterol. 2019 Feb 27;12:1756284819828238.10.1177/1756284819828238info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:03:14Zoai:repositorio.hospitaldebraga.pt:10400.23/1323Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:51.149702Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Accuracy of the new rapid test for monitoring adalimumab levels
title Accuracy of the new rapid test for monitoring adalimumab levels
spellingShingle Accuracy of the new rapid test for monitoring adalimumab levels
Rocha, C
Adalimumab
title_short Accuracy of the new rapid test for monitoring adalimumab levels
title_full Accuracy of the new rapid test for monitoring adalimumab levels
title_fullStr Accuracy of the new rapid test for monitoring adalimumab levels
title_full_unstemmed Accuracy of the new rapid test for monitoring adalimumab levels
title_sort Accuracy of the new rapid test for monitoring adalimumab levels
author Rocha, C
author_facet Rocha, C
Afonso, J
Lago, P
Arroja, B
Vieira, AI
Dias, CC
Magro, F
author_role author
author2 Afonso, J
Lago, P
Arroja, B
Vieira, AI
Dias, CC
Magro, F
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Rocha, C
Afonso, J
Lago, P
Arroja, B
Vieira, AI
Dias, CC
Magro, F
dc.subject.por.fl_str_mv Adalimumab
topic Adalimumab
description The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available rapid-test ADL quantification assay by comparing it with three established ELISA methods, using spiked samples and a set of clinical samples.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-16T12:44:42Z
2019-01-01T00:00:00Z
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/1323
url http://hdl.handle.net/10400.23/1323
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Therap Adv Gastroenterol. 2019 Feb 27;12:1756284819828238.
10.1177/1756284819828238
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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