The Lifespan and Turnover of Microglia in the Human Brain

• Autor(a) principal: Réu, Pedro
• Data de Publicação: 2017
• Outros Autores: Khosravi, Azadeh, Bernard, Samuel, Mold, Jeff E, Salehpour, Mehran, Alkass, Kanar, Perl, Shira, Tisdale, John, Possnert, Göran, Druid, Henrik, Frisén, Jonas
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/108125; https://doi.org/10.1016/j.celrep.2017.07.004
• topic: human; microglia; proliferation; renewal; turnover; Adolescent; Adult; Brain; Cell Division; Cell Proliferation; Humans; Microglia; Stem Cells

The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life.