Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis

Detalhes bibliográficos
Autor(a) principal: Huang, Hua
Data de Publicação: 2020
Outros Autores: Zuzarte-Luis, Vanessa, Fragoso, Gabriela, Calvé, Annie, Hoang, Tuan Anh, Oliero, Manon, Chabot-Roy, Geneviève, Mullins-Dansereau, Victor, Lesage, Sylvie, Santos, Manuela M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47213
Resumo: © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licen ses/by/4.0/.
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spelling Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licen ses/by/4.0/.Iron homeostasis is an essential biological process that ensures the tissue distribution of iron for various cellular processes. As the major producer of hepcidin, the liver is central to the regulation of iron metabolism. The liver is also home to many immune cells, which upon activation may greatly impact iron metabolism. Here, we focus on the role of invariant natural killer T (iNKT) cells, a subset of T lymphocytes that, in mice, is most abundant in the liver. Activation of iNKT cells with the prototypical glycosphingolipid antigen, α-galactosylceramide, resulted in immune cell proliferation and biphasic changes in iron metabolism. This involved an early phase characterized by hypoferremia, hepcidin induction and ferroportin suppression, and a second phase associated with strong suppression of hepcidin despite elevated levels of circulating and tissue iron. We further show that these changes in iron metabolism are fully dependent on iNKT cell activation. Finally, we demonstrate that the biphasic regulation of hepcidin is independent of NK and Kupffer cells, and is initially driven by the STAT3 inflammatory pathway, whereas the second phase is regulated by repression of the BMP/SMAD signaling pathway. These findings indicate that iNKT activation and the resulting cell proliferation influence iron homeostasis.This work was supported by grants from the Canadian Institutes of Health Research (CIHR, Grant no. PJT-159775) and Natural Sciences and Engineering Research Council of Canada (NSERC, Grant RGPIN-2018-06442) to MMS. HH received a PhD scholarship from the NSERC. SL is a Research Scholars Emeritus awardee from the FRQS.Springer NatureRepositório da Universidade de LisboaHuang, HuaZuzarte-Luis, VanessaFragoso, GabrielaCalvé, AnnieHoang, Tuan AnhOliero, ManonChabot-Roy, GenevièveMullins-Dansereau, VictorLesage, SylvieSantos, Manuela M.2021-04-01T16:13:55Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47213engSci Rep. 2020 Dec 3;10(1):2102610.1038/s41598-020-78037-32045-2322info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:58Zoai:repositorio.ul.pt:10451/47213Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:17.684809Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
title Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
spellingShingle Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
Huang, Hua
title_short Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
title_full Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
title_fullStr Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
title_full_unstemmed Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
title_sort Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
author Huang, Hua
author_facet Huang, Hua
Zuzarte-Luis, Vanessa
Fragoso, Gabriela
Calvé, Annie
Hoang, Tuan Anh
Oliero, Manon
Chabot-Roy, Geneviève
Mullins-Dansereau, Victor
Lesage, Sylvie
Santos, Manuela M.
author_role author
author2 Zuzarte-Luis, Vanessa
Fragoso, Gabriela
Calvé, Annie
Hoang, Tuan Anh
Oliero, Manon
Chabot-Roy, Geneviève
Mullins-Dansereau, Victor
Lesage, Sylvie
Santos, Manuela M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Huang, Hua
Zuzarte-Luis, Vanessa
Fragoso, Gabriela
Calvé, Annie
Hoang, Tuan Anh
Oliero, Manon
Chabot-Roy, Geneviève
Mullins-Dansereau, Victor
Lesage, Sylvie
Santos, Manuela M.
description © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licen ses/by/4.0/.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-01T16:13:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47213
url http://hdl.handle.net/10451/47213
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sci Rep. 2020 Dec 3;10(1):21026
10.1038/s41598-020-78037-3
2045-2322
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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