Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin

Detalhes bibliográficos
Autor(a) principal: Veloso, Sérgio Rafael Silva
Data de Publicação: 2023
Outros Autores: Marta, Eva S., Rodrigues, Pedro V., Moura, Cacilda, Amorim, Carlos O., Amaral, Vítor S., Correa-Duarte, Miguel A., Castanheira, Elisabete M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/86590
Resumo: In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe2O4 nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulation efficiencies (~70%) using doxorubicin as a model drug. The nanogels exhibited sustained drug release, with enhanced release under near-infrared (NIR) laser irradiation and acidic pH. The nanogels containing BSA-functionalized nanoparticles displayed improved sustained drug release at physiological pH, and the release kinetics followed a diffusion-controlled mechanism. These results demonstrate the potential of synthesized nanoparticles and nanogels for controlled drug delivery, offering opportunities for targeted and on-demand release in biomedical applications.
id RCAP_35e998b0d8c770e11836531a03cc9b28
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/86590
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicinnanogelschitosanalginatemulticore nanoparticlesmagnetic hyperthermiaphotothermiacontrolled releasedoxorubicincancer therapydrug deliveryCiências Médicas::Biotecnologia MédicaCiências Naturais::Ciências FísicasCiências Naturais::Ciências QuímicasEngenharia e Tecnologia::NanotecnologiaSaúde de qualidadeProdução e consumo sustentáveisIn this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe2O4 nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulation efficiencies (~70%) using doxorubicin as a model drug. The nanogels exhibited sustained drug release, with enhanced release under near-infrared (NIR) laser irradiation and acidic pH. The nanogels containing BSA-functionalized nanoparticles displayed improved sustained drug release at physiological pH, and the release kinetics followed a diffusion-controlled mechanism. These results demonstrate the potential of synthesized nanoparticles and nanogels for controlled drug delivery, offering opportunities for targeted and on-demand release in biomedical applications.This work was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020), and by the Ministerio de Economía y Competitividad de España (PID2020-113704RB-I00 and PID2020-119242RB-I00), Xunta de Galicia (Centro Singular de Investigación de Galicia—Accreditation 2019-2022 ED431G 2019/06 and IN607A 2018/5 and project ED431C 2020-06), the European Union (EU-ERDF Interreg V-A—Spain-Portugal 0245_IBEROS_1_E, 0712_ACUINANO_1_E, and 0624_2IQBIONEURO_6_E, and Interreg Atlantic Area NANOCULTURE 1.102.531), and the European Union H2020-MSCA-RISE-2019 PEPSA-MATE project. S.R.S. Veloso acknowledges FCT for a PhD grant (SFRH/BD/144017/2019). Support from MAP-Fis Doctoral Programme is also acknowledged.MDPIUniversidade do MinhoVeloso, Sérgio Rafael SilvaMarta, Eva S.Rodrigues, Pedro V.Moura, CacildaAmorim, Carlos O.Amaral, Vítor S.Correa-Duarte, Miguel A.Castanheira, Elisabete M. S.2023-08-242023-08-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/1822/86590engVeloso, S.R.S.; Marta, E.S.; Rodrigues, P.V.; Moura, C.; Amorim, C.O.; Amaral, V.S.; Correa-Duarte, M.A.; Castanheira, E.M.S. Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin. Pharmaceutics 2023, 15, 2194. https://doi.org/10.3390/pharmaceutics150921941999-492310.3390/pharmaceutics150921942194https://www.mdpi.com/1999-4923/15/9/2194info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-30T01:32:43Zoai:repositorium.sdum.uminho.pt:1822/86590Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:31:44.796613Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
title Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
spellingShingle Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
Veloso, Sérgio Rafael Silva
nanogels
chitosan
alginate
multicore nanoparticles
magnetic hyperthermia
photothermia
controlled release
doxorubicin
cancer therapy
drug delivery
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Ciências Naturais::Ciências Químicas
Engenharia e Tecnologia::Nanotecnologia
Saúde de qualidade
Produção e consumo sustentáveis
title_short Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
title_full Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
title_fullStr Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
title_full_unstemmed Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
title_sort Chitosan/alginate nanogels containing multicore magnetic nanoparticles for delivery of doxorubicin
author Veloso, Sérgio Rafael Silva
author_facet Veloso, Sérgio Rafael Silva
Marta, Eva S.
Rodrigues, Pedro V.
Moura, Cacilda
Amorim, Carlos O.
Amaral, Vítor S.
Correa-Duarte, Miguel A.
Castanheira, Elisabete M. S.
author_role author
author2 Marta, Eva S.
Rodrigues, Pedro V.
Moura, Cacilda
Amorim, Carlos O.
Amaral, Vítor S.
Correa-Duarte, Miguel A.
Castanheira, Elisabete M. S.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Veloso, Sérgio Rafael Silva
Marta, Eva S.
Rodrigues, Pedro V.
Moura, Cacilda
Amorim, Carlos O.
Amaral, Vítor S.
Correa-Duarte, Miguel A.
Castanheira, Elisabete M. S.
dc.subject.por.fl_str_mv nanogels
chitosan
alginate
multicore nanoparticles
magnetic hyperthermia
photothermia
controlled release
doxorubicin
cancer therapy
drug delivery
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Ciências Naturais::Ciências Químicas
Engenharia e Tecnologia::Nanotecnologia
Saúde de qualidade
Produção e consumo sustentáveis
topic nanogels
chitosan
alginate
multicore nanoparticles
magnetic hyperthermia
photothermia
controlled release
doxorubicin
cancer therapy
drug delivery
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Físicas
Ciências Naturais::Ciências Químicas
Engenharia e Tecnologia::Nanotecnologia
Saúde de qualidade
Produção e consumo sustentáveis
description In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe2O4 nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulation efficiencies (~70%) using doxorubicin as a model drug. The nanogels exhibited sustained drug release, with enhanced release under near-infrared (NIR) laser irradiation and acidic pH. The nanogels containing BSA-functionalized nanoparticles displayed improved sustained drug release at physiological pH, and the release kinetics followed a diffusion-controlled mechanism. These results demonstrate the potential of synthesized nanoparticles and nanogels for controlled drug delivery, offering opportunities for targeted and on-demand release in biomedical applications.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-24
2023-08-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/86590
url https://hdl.handle.net/1822/86590
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Veloso, S.R.S.; Marta, E.S.; Rodrigues, P.V.; Moura, C.; Amorim, C.O.; Amaral, V.S.; Correa-Duarte, M.A.; Castanheira, E.M.S. Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin. Pharmaceutics 2023, 15, 2194. https://doi.org/10.3390/pharmaceutics15092194
1999-4923
10.3390/pharmaceutics15092194
2194
https://www.mdpi.com/1999-4923/15/9/2194
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133585863606272

Registros relacionados