Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia

Detalhes bibliográficos
Autor(a) principal: Huri, Hasniza Zaman
Data de Publicação: 2018
Outros Autores: Huey, Chua Chew, Mustafa, Norasyikin, Mohamad, Nor Fadhilah, Kamalden, Tengku Ain
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/153816
Resumo: The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.
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spelling Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in MalaysiaType 2 Diabetes MellitusAnti-diabetic agentsMicrovascular complicationDiabetic macula edemaDiabetic retinopathyMalaysiaThe risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninode/x-emptyhttps://www.revistas.usp.br/bjps/article/view/15381610.1590/s2175-97902018000217484Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17484Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17484Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e174842175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153816/150193Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessHuri, Hasniza ZamanHuey, Chua ChewMustafa, NorasyikinMohamad, Nor FadhilahKamalden, Tengku Ain2019-03-17T13:56:22Zoai:revistas.usp.br:article/153816Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:56:22Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
title Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
spellingShingle Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
Huri, Hasniza Zaman
Type 2 Diabetes Mellitus
Anti-diabetic agents
Microvascular complication
Diabetic macula edema
Diabetic retinopathy
Malaysia
title_short Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
title_full Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
title_fullStr Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
title_full_unstemmed Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
title_sort Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
author Huri, Hasniza Zaman
author_facet Huri, Hasniza Zaman
Huey, Chua Chew
Mustafa, Norasyikin
Mohamad, Nor Fadhilah
Kamalden, Tengku Ain
author_role author
author2 Huey, Chua Chew
Mustafa, Norasyikin
Mohamad, Nor Fadhilah
Kamalden, Tengku Ain
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Huri, Hasniza Zaman
Huey, Chua Chew
Mustafa, Norasyikin
Mohamad, Nor Fadhilah
Kamalden, Tengku Ain
dc.subject.por.fl_str_mv Type 2 Diabetes Mellitus
Anti-diabetic agents
Microvascular complication
Diabetic macula edema
Diabetic retinopathy
Malaysia
topic Type 2 Diabetes Mellitus
Anti-diabetic agents
Microvascular complication
Diabetic macula edema
Diabetic retinopathy
Malaysia
description The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-07-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/153816
10.1590/s2175-97902018000217484
url https://www.revistas.usp.br/bjps/article/view/153816
identifier_str_mv 10.1590/s2175-97902018000217484
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/153816/150193
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv inode/x-empty
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17484
Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17484
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e17484
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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