Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/153816 |
Resumo: | The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients. |
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Brazilian Journal of Pharmaceutical Sciences |
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Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in MalaysiaType 2 Diabetes MellitusAnti-diabetic agentsMicrovascular complicationDiabetic macula edemaDiabetic retinopathyMalaysiaThe risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninode/x-emptyhttps://www.revistas.usp.br/bjps/article/view/15381610.1590/s2175-97902018000217484Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17484Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17484Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e174842175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153816/150193Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessHuri, Hasniza ZamanHuey, Chua ChewMustafa, NorasyikinMohamad, Nor FadhilahKamalden, Tengku Ain2019-03-17T13:56:22Zoai:revistas.usp.br:article/153816Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:56:22Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
spellingShingle |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia Huri, Hasniza Zaman Type 2 Diabetes Mellitus Anti-diabetic agents Microvascular complication Diabetic macula edema Diabetic retinopathy Malaysia |
title_short |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_full |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_fullStr |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_full_unstemmed |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_sort |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
author |
Huri, Hasniza Zaman |
author_facet |
Huri, Hasniza Zaman Huey, Chua Chew Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain |
author_role |
author |
author2 |
Huey, Chua Chew Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Huri, Hasniza Zaman Huey, Chua Chew Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain |
dc.subject.por.fl_str_mv |
Type 2 Diabetes Mellitus Anti-diabetic agents Microvascular complication Diabetic macula edema Diabetic retinopathy Malaysia |
topic |
Type 2 Diabetes Mellitus Anti-diabetic agents Microvascular complication Diabetic macula edema Diabetic retinopathy Malaysia |
description |
The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153816 10.1590/s2175-97902018000217484 |
url |
https://www.revistas.usp.br/bjps/article/view/153816 |
identifier_str_mv |
10.1590/s2175-97902018000217484 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153816/150193 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
inode/x-empty |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17484 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17484 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e17484 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222913751678976 |