Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.

Detalhes bibliográficos
Autor(a) principal: Giestas, Anabela
Data de Publicação: 2010
Outros Autores: Palma, Isabel, Ramos, Maria Helena
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687
Resumo: The renin-angiotensin-aldosterone system (RAAS) is a neuroendocrine complex system that regulates the modulation of salt and water homeostasis, and regulation of blood pressure. Through its multiple interactions it protects the endothelium, heart, brain and kidney. In addition, the RAAS regulates the vascular response to injury and inflammation. Chronic activation/dysregulation of the RAAS leads to hypertension and perpetuates a cascade of proinflammatory, prothrombotic and atherogenic effects associated with endorgan damage (heart, brain, kidney, endothelium). Consequently, the RAAS is an important therapeutic target in these situations. This article presents an overview of physiology, pathophysiology and pharmacologic modulation of the RAAS.
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spelling Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.Sistema renina-angiotensina-aldosterona e sua modulação farmacológica.The renin-angiotensin-aldosterone system (RAAS) is a neuroendocrine complex system that regulates the modulation of salt and water homeostasis, and regulation of blood pressure. Through its multiple interactions it protects the endothelium, heart, brain and kidney. In addition, the RAAS regulates the vascular response to injury and inflammation. Chronic activation/dysregulation of the RAAS leads to hypertension and perpetuates a cascade of proinflammatory, prothrombotic and atherogenic effects associated with endorgan damage (heart, brain, kidney, endothelium). Consequently, the RAAS is an important therapeutic target in these situations. This article presents an overview of physiology, pathophysiology and pharmacologic modulation of the RAAS.The renin-angiotensin-aldosterone system (RAAS) is a neuroendocrine complex system that regulates the modulation of salt and water homeostasis, and regulation of blood pressure. Through its multiple interactions it protects the endothelium, heart, brain and kidney. In addition, the RAAS regulates the vascular response to injury and inflammation. Chronic activation/dysregulation of the RAAS leads to hypertension and perpetuates a cascade of proinflammatory, prothrombotic and atherogenic effects associated with endorgan damage (heart, brain, kidney, endothelium). Consequently, the RAAS is an important therapeutic target in these situations. This article presents an overview of physiology, pathophysiology and pharmacologic modulation of the RAAS.Ordem dos Médicos2010-07-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687oai:ojs.www.actamedicaportuguesa.com:article/687Acta Médica Portuguesa; Vol. 23 No. 4 (2010): July-August; 677-88Acta Médica Portuguesa; Vol. 23 N.º 4 (2010): Julho-Agosto; 677-881646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687/365Giestas, AnabelaPalma, IsabelRamos, Maria Helenainfo:eu-repo/semantics/openAccess2022-12-20T10:56:42Zoai:ojs.www.actamedicaportuguesa.com:article/687Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:40.982135Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
Sistema renina-angiotensina-aldosterona e sua modulação farmacológica.
title Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
spellingShingle Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
Giestas, Anabela
title_short Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
title_full Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
title_fullStr Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
title_full_unstemmed Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
title_sort Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation.
author Giestas, Anabela
author_facet Giestas, Anabela
Palma, Isabel
Ramos, Maria Helena
author_role author
author2 Palma, Isabel
Ramos, Maria Helena
author2_role author
author
dc.contributor.author.fl_str_mv Giestas, Anabela
Palma, Isabel
Ramos, Maria Helena
description The renin-angiotensin-aldosterone system (RAAS) is a neuroendocrine complex system that regulates the modulation of salt and water homeostasis, and regulation of blood pressure. Through its multiple interactions it protects the endothelium, heart, brain and kidney. In addition, the RAAS regulates the vascular response to injury and inflammation. Chronic activation/dysregulation of the RAAS leads to hypertension and perpetuates a cascade of proinflammatory, prothrombotic and atherogenic effects associated with endorgan damage (heart, brain, kidney, endothelium). Consequently, the RAAS is an important therapeutic target in these situations. This article presents an overview of physiology, pathophysiology and pharmacologic modulation of the RAAS.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687
oai:ojs.www.actamedicaportuguesa.com:article/687
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/687
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/687/365
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 23 No. 4 (2010): July-August; 677-88
Acta Médica Portuguesa; Vol. 23 N.º 4 (2010): Julho-Agosto; 677-88
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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