Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications

Detalhes bibliográficos
Autor(a) principal: Pimentel, E. S.
Data de Publicação: 2020
Outros Autores: Pereira, Ricardo Brito, Marques-Almeida, T., Ribeiro, Clarisse Marta Oliveira, Vaz, F., Lanceros-Méndez, S., Cardoso, Vanessa Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/64841
Resumo: Novel microfluidic substrates based on electrospun poly(l-lactic acid) (PLLA) membranes were developed to increase the limited range of commercially available paper substrates, commonly used for the fabrication of microfluidic paper-based analytical devices. PLLA’s advantageous properties include biodegradability, biocompatibility, ease of being processed in various tailored morphologies, and cost effectiveness, among others. Oriented and nonoriented electrospun PLLA membranes were fabricated using electrospinning and the influence of fiber orientation, addition of hydrophilic additives, and plasma treatments on the morphology, physicochemical properties, and capillary flow rates were evaluated and compared with the commercial Whatman paper. In addition, a proof-of-concept application based on the colorimetric detection of glucose in printed PLLA and paper-based microfluidic systems was also performed. The results show the potential of PLLA substrates for the fabrication of portable, disposable, eco-friendly, and cost-effective microfluidic systems with controllable properties that can be tailored according to specific biotechnological application requirements, being a suitable alternative to conventional paper-based substrates.
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spelling Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applicationsMicrofluidic paper-based analytical devicesPoly(l-lactic acid) electroactive polymersMicrofluidic hydrophilicityCapillary flowElectrospun membranesPoly(L-lactic acid)Electroactive polymersMicrofluidicHydrophilicityScience & TechnologyNovel microfluidic substrates based on electrospun poly(l-lactic acid) (PLLA) membranes were developed to increase the limited range of commercially available paper substrates, commonly used for the fabrication of microfluidic paper-based analytical devices. PLLA’s advantageous properties include biodegradability, biocompatibility, ease of being processed in various tailored morphologies, and cost effectiveness, among others. Oriented and nonoriented electrospun PLLA membranes were fabricated using electrospinning and the influence of fiber orientation, addition of hydrophilic additives, and plasma treatments on the morphology, physicochemical properties, and capillary flow rates were evaluated and compared with the commercial Whatman paper. In addition, a proof-of-concept application based on the colorimetric detection of glucose in printed PLLA and paper-based microfluidic systems was also performed. The results show the potential of PLLA substrates for the fabrication of portable, disposable, eco-friendly, and cost-effective microfluidic systems with controllable properties that can be tailored according to specific biotechnological application requirements, being a suitable alternative to conventional paper-based substrates.This work was supported by the Portuguese Foundation for Science and Technology (FCT) under strategic funding UID/EEA/04436/2019 and UID/FIS/04650/2019 and projects POCI-01-0145-FEDER-028159 and POCI-01-0145-FEDER-028237. Funds provided by FCT in the framework of EuroNanoMed 2016 call, Project LungCheck ENMed/0049/2016 are also gratefully acknowledged. The authors also thank the FCT for financial support under grants SFRH/BD/140698/2018 (R.B.P.) and SFRH/BD/141136/2018 (T.M.A.) The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016- 76039-C4-3-R (AEI/FEDER, UE). Financial support from the Basque Government Industry and Education Departments under ELKARTEK, HAZITEK and PIBA (PIBA2018-06) programs, respectively, is also acknowledgeds.American Chemical SocietyUniversidade do MinhoPimentel, E. S.Pereira, Ricardo BritoMarques-Almeida, T.Ribeiro, Clarisse Marta OliveiraVaz, F.Lanceros-Méndez, S.Cardoso, Vanessa Fernandes20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/64841eng1944-82441944-825210.1021/acsami.9b1246131808332https://pubs.acs.org/doi/10.1021/acsami.9b12461#info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-07T01:20:14Zoai:repositorium.sdum.uminho.pt:1822/64841Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:18.687203Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
title Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
spellingShingle Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
Pimentel, E. S.
Microfluidic paper-based analytical devices
Poly(l-lactic acid) electroactive polymers
Microfluidic hydrophilicity
Capillary flow
Electrospun membranes
Poly(L-lactic acid)
Electroactive polymers
Microfluidic
Hydrophilicity
Science & Technology
title_short Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
title_full Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
title_fullStr Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
title_full_unstemmed Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
title_sort Tailoring electrospun Poly(L-lactic acid) nanofibers as substrates for microfluidic applications
author Pimentel, E. S.
author_facet Pimentel, E. S.
Pereira, Ricardo Brito
Marques-Almeida, T.
Ribeiro, Clarisse Marta Oliveira
Vaz, F.
Lanceros-Méndez, S.
Cardoso, Vanessa Fernandes
author_role author
author2 Pereira, Ricardo Brito
Marques-Almeida, T.
Ribeiro, Clarisse Marta Oliveira
Vaz, F.
Lanceros-Méndez, S.
Cardoso, Vanessa Fernandes
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pimentel, E. S.
Pereira, Ricardo Brito
Marques-Almeida, T.
Ribeiro, Clarisse Marta Oliveira
Vaz, F.
Lanceros-Méndez, S.
Cardoso, Vanessa Fernandes
dc.subject.por.fl_str_mv Microfluidic paper-based analytical devices
Poly(l-lactic acid) electroactive polymers
Microfluidic hydrophilicity
Capillary flow
Electrospun membranes
Poly(L-lactic acid)
Electroactive polymers
Microfluidic
Hydrophilicity
Science & Technology
topic Microfluidic paper-based analytical devices
Poly(l-lactic acid) electroactive polymers
Microfluidic hydrophilicity
Capillary flow
Electrospun membranes
Poly(L-lactic acid)
Electroactive polymers
Microfluidic
Hydrophilicity
Science & Technology
description Novel microfluidic substrates based on electrospun poly(l-lactic acid) (PLLA) membranes were developed to increase the limited range of commercially available paper substrates, commonly used for the fabrication of microfluidic paper-based analytical devices. PLLA’s advantageous properties include biodegradability, biocompatibility, ease of being processed in various tailored morphologies, and cost effectiveness, among others. Oriented and nonoriented electrospun PLLA membranes were fabricated using electrospinning and the influence of fiber orientation, addition of hydrophilic additives, and plasma treatments on the morphology, physicochemical properties, and capillary flow rates were evaluated and compared with the commercial Whatman paper. In addition, a proof-of-concept application based on the colorimetric detection of glucose in printed PLLA and paper-based microfluidic systems was also performed. The results show the potential of PLLA substrates for the fabrication of portable, disposable, eco-friendly, and cost-effective microfluidic systems with controllable properties that can be tailored according to specific biotechnological application requirements, being a suitable alternative to conventional paper-based substrates.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/64841
url https://hdl.handle.net/1822/64841
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1944-8244
1944-8252
10.1021/acsami.9b12461
31808332
https://pubs.acs.org/doi/10.1021/acsami.9b12461#
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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