More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis

Detalhes bibliográficos
Autor(a) principal: dos Santos, Ricardo F.
Data de Publicação: 2018
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/93883
Resumo: Ribosome biogenesis is a complex process involving multiple factors. The work described here is primarily centered in the study of ribosomal RNA, highlighting its central role in translation regulation. We have uncovered new regulators involved in rRNA processing, folding and degradation pathways. For the first time, we demonstrate that the widely conserved RNA chaperone Hfq, mostly known as the sRNA-mRNA matchmaker, acts as a ribosomal assembly factor in Escherichia coli, affecting rRNA processing, ribosome levels, translation efficiency and accuracy. This function is suggested to be independent of its activity as sRNA-regulator.(...)
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spelling More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesisRNARibosomeBiologyRibosome biogenesis is a complex process involving multiple factors. The work described here is primarily centered in the study of ribosomal RNA, highlighting its central role in translation regulation. We have uncovered new regulators involved in rRNA processing, folding and degradation pathways. For the first time, we demonstrate that the widely conserved RNA chaperone Hfq, mostly known as the sRNA-mRNA matchmaker, acts as a ribosomal assembly factor in Escherichia coli, affecting rRNA processing, ribosome levels, translation efficiency and accuracy. This function is suggested to be independent of its activity as sRNA-regulator.(...)Arraiano, CecíliaAndrade, JoséRUNdos Santos, Ricardo F.2022-02-28T01:30:32Z2019-022018-122019-02-01T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/93883enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:43:55Zoai:run.unl.pt:10362/93883Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:43:55Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
title More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
spellingShingle More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
dos Santos, Ricardo F.
RNA
Ribosome
Biology
title_short More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
title_full More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
title_fullStr More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
title_full_unstemmed More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
title_sort More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
author dos Santos, Ricardo F.
author_facet dos Santos, Ricardo F.
author_role author
dc.contributor.none.fl_str_mv Arraiano, Cecília
Andrade, José
RUN
dc.contributor.author.fl_str_mv dos Santos, Ricardo F.
dc.subject.por.fl_str_mv RNA
Ribosome
Biology
topic RNA
Ribosome
Biology
description Ribosome biogenesis is a complex process involving multiple factors. The work described here is primarily centered in the study of ribosomal RNA, highlighting its central role in translation regulation. We have uncovered new regulators involved in rRNA processing, folding and degradation pathways. For the first time, we demonstrate that the widely conserved RNA chaperone Hfq, mostly known as the sRNA-mRNA matchmaker, acts as a ribosomal assembly factor in Escherichia coli, affecting rRNA processing, ribosome levels, translation efficiency and accuracy. This function is suggested to be independent of its activity as sRNA-regulator.(...)
publishDate 2018
dc.date.none.fl_str_mv 2018-12
2019-02
2019-02-01T00:00:00Z
2022-02-28T01:30:32Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/93883
url http://hdl.handle.net/10362/93883
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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