More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/93883 |
Resumo: | Ribosome biogenesis is a complex process involving multiple factors. The work described here is primarily centered in the study of ribosomal RNA, highlighting its central role in translation regulation. We have uncovered new regulators involved in rRNA processing, folding and degradation pathways. For the first time, we demonstrate that the widely conserved RNA chaperone Hfq, mostly known as the sRNA-mRNA matchmaker, acts as a ribosomal assembly factor in Escherichia coli, affecting rRNA processing, ribosome levels, translation efficiency and accuracy. This function is suggested to be independent of its activity as sRNA-regulator.(...) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesisRNARibosomeBiologyRibosome biogenesis is a complex process involving multiple factors. The work described here is primarily centered in the study of ribosomal RNA, highlighting its central role in translation regulation. We have uncovered new regulators involved in rRNA processing, folding and degradation pathways. For the first time, we demonstrate that the widely conserved RNA chaperone Hfq, mostly known as the sRNA-mRNA matchmaker, acts as a ribosomal assembly factor in Escherichia coli, affecting rRNA processing, ribosome levels, translation efficiency and accuracy. This function is suggested to be independent of its activity as sRNA-regulator.(...)Arraiano, CecíliaAndrade, JoséRUNdos Santos, Ricardo F.2022-02-28T01:30:32Z2019-022018-122019-02-01T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/93883enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:43:55Zoai:run.unl.pt:10362/93883Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:43:55Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
title |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
spellingShingle |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis dos Santos, Ricardo F. RNA Ribosome Biology |
title_short |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
title_full |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
title_fullStr |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
title_full_unstemmed |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
title_sort |
More than an RNA matchmaker: Expanding the roles of Hfq into ribosome biogenesis |
author |
dos Santos, Ricardo F. |
author_facet |
dos Santos, Ricardo F. |
author_role |
author |
dc.contributor.none.fl_str_mv |
Arraiano, Cecília Andrade, José RUN |
dc.contributor.author.fl_str_mv |
dos Santos, Ricardo F. |
dc.subject.por.fl_str_mv |
RNA Ribosome Biology |
topic |
RNA Ribosome Biology |
description |
Ribosome biogenesis is a complex process involving multiple factors. The work described here is primarily centered in the study of ribosomal RNA, highlighting its central role in translation regulation. We have uncovered new regulators involved in rRNA processing, folding and degradation pathways. For the first time, we demonstrate that the widely conserved RNA chaperone Hfq, mostly known as the sRNA-mRNA matchmaker, acts as a ribosomal assembly factor in Escherichia coli, affecting rRNA processing, ribosome levels, translation efficiency and accuracy. This function is suggested to be independent of its activity as sRNA-regulator.(...) |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12 2019-02 2019-02-01T00:00:00Z 2022-02-28T01:30:32Z |
dc.type.driver.fl_str_mv |
doctoral thesis |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/93883 |
url |
http://hdl.handle.net/10362/93883 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817545730722627584 |