Targeting NF-κB signaling pathway in cancer by dietary polyphenols

• Autor(a) principal: Khan, Haroon
• Data de Publicação: 2019
• Outros Autores: Ullah, Hammad, Castilho, Paula Cristina Machado Ferreira, Gomila, Antoni Sureda, D'Onofrio, Grazia, Filosa, Rosanna, Wang, Fang, Nabavi, Seyed Mohammad, Daglia, Maria, Silva, Ana Sanches, Rengasamy, Kannan R. R., Ou, Juanying, Zou, Xiaobo, Xiao, Jianbo, Cao, Hui
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.13/3198
• topic: Dietary polyphenols; Cancer; Signaling pathway; Nuclear factor-jB; Phosphorylation; .; Faculdade de Ciências Exatas e da Engenharia; Centro de Química da Madeira

Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.