Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances

Detalhes bibliográficos
Autor(a) principal: Luo, Honglin
Data de Publicação: 2020
Outros Autores: Gan, Deqiang, Gama, F. M., Tu, Junpin, Yao, Fanglian, Zhang, Quanchao, Ao, Haiyong, Yang, Zhiwei, Li, Junjie, Wan, Yizao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62344
Resumo: Supplementary data to this article can be found online at https:// doi.org/10.1016/j.msec.2019.110416.
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spelling Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performancesCelluloseMicrofiberNanofiberTissue regenerationBiomimeticScience & TechnologySupplementary data to this article can be found online at https:// doi.org/10.1016/j.msec.2019.110416.Developing fibrous scaffolds with hierarchical structures that closely mimic natural extracellular matrix (ECM) is highly desirable. However, fabricating scaffolds with true nanofibers (<100?nm) and submicrofibers (<1??m) remains a big challenge. In this work, to mimic the fibrillar structure of natural ECM, bacterial cellulose (BC) nanofibers were hybridized with cellulose acetate (CA) submicrofibers for the first time. The interpenetrated nano-submicron fibrous BC/CA scaffold was fabricated using the combined electrospinning and modified in situ biosynthesis method. The BC/CA scaffold has an integrated symmetrical nanostructure in which BC nanofibers (42?nm in diameter) penetrate into the submicrofibrous CA (820?nm in diameter) scaffold. The BC/CA scaffold shows an interconnected porous structure with a high porosity of >90%. Additionally, the combination of CA submicrofibers with BC nanofibers leads to significantly improved mechanical properties over nanofibrous BC and submicrofibrous CA scaffolds and enlarged pores over nanofibrous BC scaffold. In addition, the biological behaviors of prepared BC/CA on MC3T3-E1 cells were investigated. Results suggested that BC/CA scaffold is beneficial for cell migration and proliferation. Moreover, the BC/CA scaffold shows higher alkaline phosphatase (ALP) activity, and calcium depositions. In addition, the hierarchical structures can effectively improve the expression of osteogenic gene (ALP mRNA and Runx2 mRNA) and protein (ALP). We believe that the methodology might provide biomimetic morphological microenvironments for enhanced tissue regeneration.This work is supported by the National Natural Science Foundation of China (Grant nos. 51973058, 31870963, 51572187, and 51563008), the Excellent Young Scientists Fund by National Natural Science Foundation of China (No. 31722022), the Youth Science Foundation of Jiangxi Province (No. 20171ACB21036 and 20181BAB216010).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoLuo, HonglinGan, DeqiangGama, F. M.Tu, JunpinYao, FanglianZhang, QuanchaoAo, HaiyongYang, ZhiweiLi, JunjieWan, Yizao2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62344engLuo, Honglin; Gan, Deqiang; Gama, F. M.; Tu, Junpin; Yao, Fanglian; Zhang, Quanchao; Ao, Haiyong; Yang, Zhiwei; Li, Junjie; Wan, Yizao, Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances. Materials Science & Engineering C-Materials for Biological Applications, 108(110416), 20200928-49310928-493110.1016/j.msec.2019.11041631923960http://www.journals.elsevier.com/materials-science-and-engineering-c/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:28Zoai:repositorium.sdum.uminho.pt:1822/62344Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:20:55.055087Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
title Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
spellingShingle Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
Luo, Honglin
Cellulose
Microfiber
Nanofiber
Tissue regeneration
Biomimetic
Science & Technology
title_short Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
title_full Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
title_fullStr Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
title_full_unstemmed Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
title_sort Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances
author Luo, Honglin
author_facet Luo, Honglin
Gan, Deqiang
Gama, F. M.
Tu, Junpin
Yao, Fanglian
Zhang, Quanchao
Ao, Haiyong
Yang, Zhiwei
Li, Junjie
Wan, Yizao
author_role author
author2 Gan, Deqiang
Gama, F. M.
Tu, Junpin
Yao, Fanglian
Zhang, Quanchao
Ao, Haiyong
Yang, Zhiwei
Li, Junjie
Wan, Yizao
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Luo, Honglin
Gan, Deqiang
Gama, F. M.
Tu, Junpin
Yao, Fanglian
Zhang, Quanchao
Ao, Haiyong
Yang, Zhiwei
Li, Junjie
Wan, Yizao
dc.subject.por.fl_str_mv Cellulose
Microfiber
Nanofiber
Tissue regeneration
Biomimetic
Science & Technology
topic Cellulose
Microfiber
Nanofiber
Tissue regeneration
Biomimetic
Science & Technology
description Supplementary data to this article can be found online at https:// doi.org/10.1016/j.msec.2019.110416.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
2020-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62344
url http://hdl.handle.net/1822/62344
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Luo, Honglin; Gan, Deqiang; Gama, F. M.; Tu, Junpin; Yao, Fanglian; Zhang, Quanchao; Ao, Haiyong; Yang, Zhiwei; Li, Junjie; Wan, Yizao, Interpenetrated nano- and submicro-fibrous biomimetic scaffolds towards enhanced mechanical and biological performances. Materials Science & Engineering C-Materials for Biological Applications, 108(110416), 2020
0928-4931
0928-4931
10.1016/j.msec.2019.110416
31923960
http://www.journals.elsevier.com/materials-science-and-engineering-c/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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