Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior

Detalhes bibliográficos
Autor(a) principal: Wan, Yizao
Data de Publicação: 2020
Outros Autores: Lin, Zhonghong, Zhang, Quanchao, Gan, Deqiang, Gama, F. M., Tu, Junpin, Luo, Honglin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/65083
Resumo: Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10570-020-03078-w) contains supplementary material, which is available to authorized users.
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spelling Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behaviorBiomaterialsFibersBiomimeticCelluloseBiocompatibilityMechanical propertiesScience & TechnologyElectronic supplementary material The online version of this article (https://doi.org/10.1007/s10570-020-03078-w) contains supplementary material, which is available to authorized users.The impact of graphene oxide (GO) on normal cells has been widely investigated. However, much less is known on its effect on cancer cells. Herein, GO nanosheets were incorporated into electrospun cellulose acetate (CA) microfibers. The GO-incorporated CA (GO/CA) microfibers were combined with bacterial cellulose (BC) nanofibers via in situ biosynthesis to obtain the nano-microfibrous scaffolds. The GO/CA-BC scaffolds were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). The GO/CA-BC scaffolds were used for breast cancer cell culture to evaluate the effect of GO on cancer cell behavior. Fluorescence images revealed large multicellular clusters on the surface of GO/CA-BC scaffolds. Compared to the bare CA-BC scaffold, the GO/CA-BC scaffolds not only showed enhanced mechanical properties but also improved cell proliferation. It is expected that the GO/CA-BC scaffolds would provide a suitable microenvironment for the culture of cancer cells which is necessary for drug screening and cell biology study.This work was supported by National Natural Science Foundation of China (Grant nos. 51572187, 51973058, 31660264, 31870963), the Key Research and Development Program of Jiangxi Province (No. 20192ACB80008), and the Youth Science Foundation of Jiangxi Province (No. 20181BAB216010), and Key Project of Natural Science Foundation of Jiangxi Province (No. 20161ACB20018).info:eu-repo/semantics/publishedVersionSpringerUniversidade do MinhoWan, YizaoLin, ZhonghongZhang, QuanchaoGan, DeqiangGama, F. M.Tu, JunpinLuo, Honglin2020-03-032020-03-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65083engWan, Yizao; Lin, Zhonghong; Zhang, Quanchao; Gan, Deqiang; Gama, F. M.; Tu, Junpin; Luo, Honglin, Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior. Cellulose, 27, 4471-4485, 20200969-023910.1007/s10570-020-03078-whttp://www.springer.com/chemistry/organic+chemistry/journal/10570info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T05:38:44Zoai:repositorium.sdum.uminho.pt:1822/65083Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T05:38:44Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
title Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
spellingShingle Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
Wan, Yizao
Biomaterials
Fibers
Biomimetic
Cellulose
Biocompatibility
Mechanical properties
Science & Technology
title_short Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
title_full Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
title_fullStr Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
title_full_unstemmed Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
title_sort Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior
author Wan, Yizao
author_facet Wan, Yizao
Lin, Zhonghong
Zhang, Quanchao
Gan, Deqiang
Gama, F. M.
Tu, Junpin
Luo, Honglin
author_role author
author2 Lin, Zhonghong
Zhang, Quanchao
Gan, Deqiang
Gama, F. M.
Tu, Junpin
Luo, Honglin
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Wan, Yizao
Lin, Zhonghong
Zhang, Quanchao
Gan, Deqiang
Gama, F. M.
Tu, Junpin
Luo, Honglin
dc.subject.por.fl_str_mv Biomaterials
Fibers
Biomimetic
Cellulose
Biocompatibility
Mechanical properties
Science & Technology
topic Biomaterials
Fibers
Biomimetic
Cellulose
Biocompatibility
Mechanical properties
Science & Technology
description Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10570-020-03078-w) contains supplementary material, which is available to authorized users.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-03
2020-03-03T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/65083
url http://hdl.handle.net/1822/65083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Wan, Yizao; Lin, Zhonghong; Zhang, Quanchao; Gan, Deqiang; Gama, F. M.; Tu, Junpin; Luo, Honglin, Incorporating graphene oxide into biomimetic nano-microfibrous cellulose scaffolds for enhanced breast cancer cell behavior. Cellulose, 27, 4471-4485, 2020
0969-0239
10.1007/s10570-020-03078-w
http://www.springer.com/chemistry/organic+chemistry/journal/10570
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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