Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death

Detalhes bibliográficos
Autor(a) principal: Penha-Gonçalves, Carlos
Data de Publicação: 2014
Outros Autores: Gozzelino, Raffaella, de Moraes, Luciana V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/369
Resumo: This deposit is composed by the main article, and it hasn't any supplementary materials associated.
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spelling Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal deathpregnancy malariahemeironfetal deathtrophoblastThis deposit is composed by the main article, and it hasn't any supplementary materials associated.Plasmodium infection during gestation may lead to severe clinical manifestations including abortion, stillbirth, intrauterine growth retardation, and low birth weight. Mechanisms underlying such poor pregnancy outcomes are still unclear. In the animal model of severe placental malaria (PM), in utero fetal death frequently occurs and mothers often succumb to infection before or immediately after delivery. Plasmodium berghei-infected erythrocytes (IEs) continuously accumulate in the placenta, where they are then phagocytosed by fetal-derived placental cells, namely trophoblasts. Inside the phagosomes, disruption of IEs leads to the release of non-hemoglobin bound heme, which is subsequently catabolized by heme oxygenase-1 into carbon monoxide, biliverdin, and labile iron. Fine-tuned regulatory mechanisms operate to maintain iron homeostasis, preventing the deleterious effect of iron-induced oxidative stress. Our preliminary results demonstrate that iron overload in trophoblasts of P. berghei-infected placenta is associated with fetal death. Placentas which supported normally developing embryos showed no iron accumulation within the trophoblasts. Placentas from dead fetuses showed massive iron accumulation, which was associated with parasitic burden. Here we present preliminary data suggesting that disruption of iron homeostasis in trophoblasts during the course of PM is a consequence of heme accumulation after intense IE engulfment. We propose that iron overload in placenta is a pathogenic component of PM, contributing to fetal death. The mechanism through which it operates still needs to be elucidated.FCT: Portugal (EXPL-IMI-IMU-0428/2013), SFRH/BPD/44256/2008, SFRH/BPD/44486/2008.Frontiers Research FoundationARCAPenha-Gonçalves, CarlosGozzelino, Raffaellade Moraes, Luciana V.2015-10-06T15:38:19Z2014-07-012014-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/369engPenha-Gonçalves C, Gozzelino R and de Moraes LV (2014) Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death. Front. Pharmacol. 5:155. doi: 10.3389/fphar.2014.0015510.3389/fphar.2014.00155info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:46ZPortal AgregadorONG
dc.title.none.fl_str_mv Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
title Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
spellingShingle Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
Penha-Gonçalves, Carlos
pregnancy malaria
heme
iron
fetal death
trophoblast
title_short Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
title_full Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
title_fullStr Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
title_full_unstemmed Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
title_sort Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death
author Penha-Gonçalves, Carlos
author_facet Penha-Gonçalves, Carlos
Gozzelino, Raffaella
de Moraes, Luciana V.
author_role author
author2 Gozzelino, Raffaella
de Moraes, Luciana V.
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Penha-Gonçalves, Carlos
Gozzelino, Raffaella
de Moraes, Luciana V.
dc.subject.por.fl_str_mv pregnancy malaria
heme
iron
fetal death
trophoblast
topic pregnancy malaria
heme
iron
fetal death
trophoblast
description This deposit is composed by the main article, and it hasn't any supplementary materials associated.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
2014-07-01T00:00:00Z
2015-10-06T15:38:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/369
url http://hdl.handle.net/10400.7/369
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Penha-Gonçalves C, Gozzelino R and de Moraes LV (2014) Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death. Front. Pharmacol. 5:155. doi: 10.3389/fphar.2014.00155
10.3389/fphar.2014.00155
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1777301592523931648

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