Inhalation of peptide-loaded nanoparticles improves heart failure
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/8927 |
Resumo: | Peptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small (<50 nm in diameter) biocompatible and biodegradable calcium phosphate nanoparticles (CaPs) allows for rapid translocation of CaPs from the pulmonary tree to the bloodstream and to the myocardium, where their cargo is quickly released. Treatment of a rodent model of diabetic cardiomyopathy by inhalation of CaPs loaded with a therapeutic mimetic peptide that we previously demonstrated to improve myocardial contraction resulted in restoration of cardiac function. Translation to a porcine large animal model provides evidence that inhalation of a peptide-loaded CaP formulation is an effective method of targeted administration to the heart. Together, these results demonstrate that inhalation of biocompatible tailored peptide nanocarriers represents a pioneering approach for the pharmacological treatment of heart failure. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Inhalation of peptide-loaded nanoparticles improves heart failurePeptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small (<50 nm in diameter) biocompatible and biodegradable calcium phosphate nanoparticles (CaPs) allows for rapid translocation of CaPs from the pulmonary tree to the bloodstream and to the myocardium, where their cargo is quickly released. Treatment of a rodent model of diabetic cardiomyopathy by inhalation of CaPs loaded with a therapeutic mimetic peptide that we previously demonstrated to improve myocardial contraction resulted in restoration of cardiac function. Translation to a porcine large animal model provides evidence that inhalation of a peptide-loaded CaP formulation is an effective method of targeted administration to the heart. Together, these results demonstrate that inhalation of biocompatible tailored peptide nanocarriers represents a pioneering approach for the pharmacological treatment of heart failure.American Association for the Advancement of ScienceIC-OnlineMiragoli, MicheleCeriotti, PaolaIafisco, MicheleVacchiano, MarcoSalvarani, NicolòCarullo, PierluigiRamírez-Rodríguez, Gloria BelénFernandes Patrício, Tatiana MarisaDegli Esposti, LorenzoRossi, FrancescaRavanetti, FrancescaPinelli, SilvanaAlinovi, RossellaErreni, MarcoROSSI, StefanoCondorelli, GianluigiPost, HeinerTAMPIERI, ANNACatalucci, Daniele2023-11-15T17:50:50Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8927engMichele Miragoli et al. ,Inhalation of peptide-loaded nanoparticles improves heart failure.Sci. Transl. Med.10,eaan6205(2018).DOI:10.1126/scitranslmed.aan62051946-6234https://www.science.org/doi/10.1126/scitranslmed.aan62051946-6242info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:58:32Zoai:iconline.ipleiria.pt:10400.8/8927Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:32.571671Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inhalation of peptide-loaded nanoparticles improves heart failure |
title |
Inhalation of peptide-loaded nanoparticles improves heart failure |
spellingShingle |
Inhalation of peptide-loaded nanoparticles improves heart failure Miragoli, Michele |
title_short |
Inhalation of peptide-loaded nanoparticles improves heart failure |
title_full |
Inhalation of peptide-loaded nanoparticles improves heart failure |
title_fullStr |
Inhalation of peptide-loaded nanoparticles improves heart failure |
title_full_unstemmed |
Inhalation of peptide-loaded nanoparticles improves heart failure |
title_sort |
Inhalation of peptide-loaded nanoparticles improves heart failure |
author |
Miragoli, Michele |
author_facet |
Miragoli, Michele Ceriotti, Paola Iafisco, Michele Vacchiano, Marco Salvarani, Nicolò Carullo, Pierluigi Ramírez-Rodríguez, Gloria Belén Fernandes Patrício, Tatiana Marisa Degli Esposti, Lorenzo Rossi, Francesca Ravanetti, Francesca Pinelli, Silvana Alinovi, Rossella Erreni, Marco ROSSI, Stefano Condorelli, Gianluigi Post, Heiner TAMPIERI, ANNA Catalucci, Daniele |
author_role |
author |
author2 |
Ceriotti, Paola Iafisco, Michele Vacchiano, Marco Salvarani, Nicolò Carullo, Pierluigi Ramírez-Rodríguez, Gloria Belén Fernandes Patrício, Tatiana Marisa Degli Esposti, Lorenzo Rossi, Francesca Ravanetti, Francesca Pinelli, Silvana Alinovi, Rossella Erreni, Marco ROSSI, Stefano Condorelli, Gianluigi Post, Heiner TAMPIERI, ANNA Catalucci, Daniele |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Miragoli, Michele Ceriotti, Paola Iafisco, Michele Vacchiano, Marco Salvarani, Nicolò Carullo, Pierluigi Ramírez-Rodríguez, Gloria Belén Fernandes Patrício, Tatiana Marisa Degli Esposti, Lorenzo Rossi, Francesca Ravanetti, Francesca Pinelli, Silvana Alinovi, Rossella Erreni, Marco ROSSI, Stefano Condorelli, Gianluigi Post, Heiner TAMPIERI, ANNA Catalucci, Daniele |
description |
Peptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small (<50 nm in diameter) biocompatible and biodegradable calcium phosphate nanoparticles (CaPs) allows for rapid translocation of CaPs from the pulmonary tree to the bloodstream and to the myocardium, where their cargo is quickly released. Treatment of a rodent model of diabetic cardiomyopathy by inhalation of CaPs loaded with a therapeutic mimetic peptide that we previously demonstrated to improve myocardial contraction resulted in restoration of cardiac function. Translation to a porcine large animal model provides evidence that inhalation of a peptide-loaded CaP formulation is an effective method of targeted administration to the heart. Together, these results demonstrate that inhalation of biocompatible tailored peptide nanocarriers represents a pioneering approach for the pharmacological treatment of heart failure. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2023-11-15T17:50:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8927 |
url |
http://hdl.handle.net/10400.8/8927 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Michele Miragoli et al. ,Inhalation of peptide-loaded nanoparticles improves heart failure.Sci. Transl. Med.10,eaan6205(2018).DOI:10.1126/scitranslmed.aan6205 1946-6234 https://www.science.org/doi/10.1126/scitranslmed.aan6205 1946-6242 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
publisher.none.fl_str_mv |
American Association for the Advancement of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137006813446144 |