An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/14918 |
Resumo: | The delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed. |
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An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalationProtein deliveryPolymeric nanoparticleParticle depositionBronchiLungPulmonary deliveryInhalationAtomizationSpray-dryingDry powderThe delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed.FCT: UIDB/50006/2020, UIDB/04326/2020, and UIDB/04565/2020.MDPISapientiaMarante, TâniaViegas, Cláudia SofiaDuarte, InêsMacedo, Ana S.Fonte, Pedro2020-12-17T10:32:44Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/14918eng1999-492310.3390/pharmaceutics12111032info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:27:16Zoai:sapientia.ualg.pt:10400.1/14918Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:05:51.637376Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
title |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
spellingShingle |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation Marante, Tânia Protein delivery Polymeric nanoparticle Particle deposition Bronchi Lung Pulmonary delivery Inhalation Atomization Spray-drying Dry powder |
title_short |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
title_full |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
title_fullStr |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
title_full_unstemmed |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
title_sort |
An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation |
author |
Marante, Tânia |
author_facet |
Marante, Tânia Viegas, Cláudia Sofia Duarte, Inês Macedo, Ana S. Fonte, Pedro |
author_role |
author |
author2 |
Viegas, Cláudia Sofia Duarte, Inês Macedo, Ana S. Fonte, Pedro |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Marante, Tânia Viegas, Cláudia Sofia Duarte, Inês Macedo, Ana S. Fonte, Pedro |
dc.subject.por.fl_str_mv |
Protein delivery Polymeric nanoparticle Particle deposition Bronchi Lung Pulmonary delivery Inhalation Atomization Spray-drying Dry powder |
topic |
Protein delivery Polymeric nanoparticle Particle deposition Bronchi Lung Pulmonary delivery Inhalation Atomization Spray-drying Dry powder |
description |
The delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-17T10:32:44Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/14918 |
url |
http://hdl.handle.net/10400.1/14918 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1999-4923 10.3390/pharmaceutics12111032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133298854723584 |