An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation

Detalhes bibliográficos
Autor(a) principal: Marante, Tânia
Data de Publicação: 2020
Outros Autores: Viegas, Cláudia Sofia, Duarte, Inês, Macedo, Ana S., Fonte, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/14918
Resumo: The delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed.
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spelling An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalationProtein deliveryPolymeric nanoparticleParticle depositionBronchiLungPulmonary deliveryInhalationAtomizationSpray-dryingDry powderThe delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed.FCT: UIDB/50006/2020, UIDB/04326/2020, and UIDB/04565/2020.MDPISapientiaMarante, TâniaViegas, Cláudia SofiaDuarte, InêsMacedo, Ana S.Fonte, Pedro2020-12-17T10:32:44Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/14918eng1999-492310.3390/pharmaceutics12111032info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:27:16Zoai:sapientia.ualg.pt:10400.1/14918Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:05:51.637376Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
title An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
spellingShingle An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
Marante, Tânia
Protein delivery
Polymeric nanoparticle
Particle deposition
Bronchi
Lung
Pulmonary delivery
Inhalation
Atomization
Spray-drying
Dry powder
title_short An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
title_full An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
title_fullStr An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
title_full_unstemmed An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
title_sort An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation
author Marante, Tânia
author_facet Marante, Tânia
Viegas, Cláudia Sofia
Duarte, Inês
Macedo, Ana S.
Fonte, Pedro
author_role author
author2 Viegas, Cláudia Sofia
Duarte, Inês
Macedo, Ana S.
Fonte, Pedro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Marante, Tânia
Viegas, Cláudia Sofia
Duarte, Inês
Macedo, Ana S.
Fonte, Pedro
dc.subject.por.fl_str_mv Protein delivery
Polymeric nanoparticle
Particle deposition
Bronchi
Lung
Pulmonary delivery
Inhalation
Atomization
Spray-drying
Dry powder
topic Protein delivery
Polymeric nanoparticle
Particle deposition
Bronchi
Lung
Pulmonary delivery
Inhalation
Atomization
Spray-drying
Dry powder
description The delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-17T10:32:44Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/14918
url http://hdl.handle.net/10400.1/14918
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
10.3390/pharmaceutics12111032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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