Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/162708 |
Resumo: | 2019/15960-6, São Paulo Research Foundation in Brazil (FAPESP) and FCT/Minister of Science, Technology and Higher Education in Portugal (MCTES) and by European Regional Development Fund (FEDER) funds through the COMPETE 2020 Program in the framework of ORAiDEA project (ref n° 39985 - AAC 31/SI/2017). The authors would also like to acknowledge Materials Research Center (CENIMAT) of the Associated Laboratory Institute of Nanostructures, Nanomodeling and Nanofabrication (i3N), NOVA University of Lisbon CENIMAT|i3N and National Council for Scientific and Technological Development in Brazil CNPq (303149/2018-3). Ibrahim Fatih Cengiz acknowledges the FCT distinction attributed to him under the “Estímulo ao Emprego Científico” program (2021.01969.CEECIND). The authors thank the financial support provided under the projects: “HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological, and infectious diseases”, reference NORTE-01-0145-FEDER-000039, funded by the Norte Portugal Regional Coordination and Development Commission (CCDR-N), under the NORTE2020 Program; Projects LA/P/0037/2020. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society. |
| id |
RCAP_38acbb32b245195868ca745aa044f7da |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/162708 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillersbioactive glassbone defectsencapsulationmacrospheresstrontiumElectronic, Optical and Magnetic MaterialsBiomaterialsPolymers and PlasticsMaterials ChemistrySDG 3 - Good Health and Well-being2019/15960-6, São Paulo Research Foundation in Brazil (FAPESP) and FCT/Minister of Science, Technology and Higher Education in Portugal (MCTES) and by European Regional Development Fund (FEDER) funds through the COMPETE 2020 Program in the framework of ORAiDEA project (ref n° 39985 - AAC 31/SI/2017). The authors would also like to acknowledge Materials Research Center (CENIMAT) of the Associated Laboratory Institute of Nanostructures, Nanomodeling and Nanofabrication (i3N), NOVA University of Lisbon CENIMAT|i3N and National Council for Scientific and Technological Development in Brazil CNPq (303149/2018-3). Ibrahim Fatih Cengiz acknowledges the FCT distinction attributed to him under the “Estímulo ao Emprego Científico” program (2021.01969.CEECIND). The authors thank the financial support provided under the projects: “HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological, and infectious diseases”, reference NORTE-01-0145-FEDER-000039, funded by the Norte Portugal Regional Coordination and Development Commission (CCDR-N), under the NORTE2020 Program; Projects LA/P/0037/2020. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.Traditional bioactive glass powders are typically composed of irregular particles that can be packed into dense configurations presenting low interconnectivity, which can limit bone ingrowth. The use of novel biocomposite sphere formulations comprising bioactive factors as bone fillers are most advantageous, as it simultaneously allows for packing the particles in a 3-dimensional manner to achieve an adequate interconnected porosity, enhanced biological performance, and ultimately a superior new bone formation. In this work, we develop and characterize novel biocomposite macrospheres of Sr-bioactive glass using sodium alginate, polylactic acid (PLA), and chitosan (CH) as encapsulating materials for finding applications as bone fillers. The biocomposite macrospheres that were obtained using PLA have a larger size distribution and higher porosity and an interconnectivity of 99.7%. Loose apatite particles were observed on the surface of macrospheres prepared with alginate and CH by means of soaking into a simulated body fluid (SBF) for 7 days. A dense apatite layer was formed on the biocomposite macrospheres’ surface produced with PLA, which served to protect PLA from degradation. In vitro investigations demonstrated that biocomposite macrospheres had minimal cytotoxic effects on a human osteosarcoma cell line (SaOS-2 cells). However, the accelerated degradation of PLA due to the degradation of bioactive glass may account for the observed decrease in SaOS-2 cells viability. Among the biocomposite macrospheres, those composed of PLA exhibited the most promising characteristics for their potential use as fillers in bone tissue repair applications.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaRUNde Oliveira, Ivone Reginados Santos Gonçalves, IsabelaWallace dos Santos, KennedyLança, Maria CarmoVieira, TâniaCarvalho Silva, JorgeCengiz, Ibrahim FatihReis, Rui LuísOliveira, Joaquim MiguelMiranda Ribeiro Borges, João Paulo2024-01-24T17:01:54Z2023-11-082023-11-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/162708eng2694-2461PURE: 81995512https://doi.org/10.1021/acsmaterialsau.3c00048info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:39Zoai:run.unl.pt:10362/162708Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:02.085207Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| title |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| spellingShingle |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers de Oliveira, Ivone Regina bioactive glass bone defects encapsulation macrospheres strontium Electronic, Optical and Magnetic Materials Biomaterials Polymers and Plastics Materials Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| title_full |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| title_fullStr |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| title_full_unstemmed |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| title_sort |
Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers |
| author |
de Oliveira, Ivone Regina |
| author_facet |
de Oliveira, Ivone Regina dos Santos Gonçalves, Isabela Wallace dos Santos, Kennedy Lança, Maria Carmo Vieira, Tânia Carvalho Silva, Jorge Cengiz, Ibrahim Fatih Reis, Rui Luís Oliveira, Joaquim Miguel Miranda Ribeiro Borges, João Paulo |
| author_role |
author |
| author2 |
dos Santos Gonçalves, Isabela Wallace dos Santos, Kennedy Lança, Maria Carmo Vieira, Tânia Carvalho Silva, Jorge Cengiz, Ibrahim Fatih Reis, Rui Luís Oliveira, Joaquim Miguel Miranda Ribeiro Borges, João Paulo |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais DF – Departamento de Física RUN |
| dc.contributor.author.fl_str_mv |
de Oliveira, Ivone Regina dos Santos Gonçalves, Isabela Wallace dos Santos, Kennedy Lança, Maria Carmo Vieira, Tânia Carvalho Silva, Jorge Cengiz, Ibrahim Fatih Reis, Rui Luís Oliveira, Joaquim Miguel Miranda Ribeiro Borges, João Paulo |
| dc.subject.por.fl_str_mv |
bioactive glass bone defects encapsulation macrospheres strontium Electronic, Optical and Magnetic Materials Biomaterials Polymers and Plastics Materials Chemistry SDG 3 - Good Health and Well-being |
| topic |
bioactive glass bone defects encapsulation macrospheres strontium Electronic, Optical and Magnetic Materials Biomaterials Polymers and Plastics Materials Chemistry SDG 3 - Good Health and Well-being |
| description |
2019/15960-6, São Paulo Research Foundation in Brazil (FAPESP) and FCT/Minister of Science, Technology and Higher Education in Portugal (MCTES) and by European Regional Development Fund (FEDER) funds through the COMPETE 2020 Program in the framework of ORAiDEA project (ref n° 39985 - AAC 31/SI/2017). The authors would also like to acknowledge Materials Research Center (CENIMAT) of the Associated Laboratory Institute of Nanostructures, Nanomodeling and Nanofabrication (i3N), NOVA University of Lisbon CENIMAT|i3N and National Council for Scientific and Technological Development in Brazil CNPq (303149/2018-3). Ibrahim Fatih Cengiz acknowledges the FCT distinction attributed to him under the “Estímulo ao Emprego Científico” program (2021.01969.CEECIND). The authors thank the financial support provided under the projects: “HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological, and infectious diseases”, reference NORTE-01-0145-FEDER-000039, funded by the Norte Portugal Regional Coordination and Development Commission (CCDR-N), under the NORTE2020 Program; Projects LA/P/0037/2020. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-08 2023-11-08T00:00:00Z 2024-01-24T17:01:54Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/162708 |
| url |
http://hdl.handle.net/10362/162708 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2694-2461 PURE: 81995512 https://doi.org/10.1021/acsmaterialsau.3c00048 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
13 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799138170898481152 |