Stepwise functional evolution in a fungal sugar transporter family

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Carla
Data de Publicação: 2016
Outros Autores: Coelho, Mauro A., Salema-Oom, Madalena, Gonçalves, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/17556
Resumo: This is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record Mol Biol Evol (2016) 33 (2): 352-366 is available online at: http://mbe.oxfordjournals.org/content/33/2/352 DOI 10.1093/molbev/msv220.
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spelling Stepwise functional evolution in a fungal sugar transporter familyFructose transportYeast metabolic evolutionHorizontal gene transferFfzDHA1This is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record Mol Biol Evol (2016) 33 (2): 352-366 is available online at: http://mbe.oxfordjournals.org/content/33/2/352 DOI 10.1093/molbev/msv220."Sugar transport is of the utmost importance for most cells and is important to a wide range of applied fields. However, despite the straightforward in silico assignment of many novel transporters, including sugar porters, to existing families, their exact biological role and evolutionary trajectory often remain unclear, mainly because biochemical characterization of membrane proteins is inherently challenging, but also owing to their uncommonly turbulent evolutionary histories. In addition, many important shifts in membrane carrier function are apparently ancient, which further limits our ability to reconstruct evolutionary trajectories in a reliable manner.Here we circumvented some of these obstacles by examining the relatively recent emergence of a unique family of fungal sugar facilitators, related to drug antiporters. The former transporters, named Ffz, were previously shown to be required for fructophilic metabolism in yeasts. We first exploited the wealth of fungal genomic data available to define a comprehensive but well-delimited family of Ffz-like transporters, showing that they are only present in Dikarya. Subsequently, a combination of phylogenetic analyses and in vivo functional characterization was used to retrace important changes in function, while highlighting the evolutionary events that are most likely to have determined extant distribution of the gene, such as horizontal gene transfers (HGTs). One such HGT event is proposed to have set the stage for the onset of fructophilic metabolism in yeasts, a trait that according to our results may be the metabolic hallmark of approximately one hundred yeast species that thrive in sugar rich environments."Oxford University PressRepositório ComumGonçalves, CarlaCoelho, Mauro A.Salema-Oom, MadalenaGonçalves, Paula2017-03-01T01:30:10Z2016-02-01T00:00:00Z2016-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.26/17556engCarla Gonçalves, Marco A. Coelho, Madalena Salema-Oom, and Paula Gonçalves. Stepwise Functional Evolution in a Fungal Sugar Transporter Family. Mol Biol Evol (2016) 33 (2): 352-366 first published online October 15, 2015. doi:10.1093/molbev/msv2201537-171910.1093/molbev/msv220info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:43Zoai:comum.rcaap.pt:10400.26/17556Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:43.050226Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Stepwise functional evolution in a fungal sugar transporter family
title Stepwise functional evolution in a fungal sugar transporter family
spellingShingle Stepwise functional evolution in a fungal sugar transporter family
Gonçalves, Carla
Fructose transport
Yeast metabolic evolution
Horizontal gene transfer
Ffz
DHA1
title_short Stepwise functional evolution in a fungal sugar transporter family
title_full Stepwise functional evolution in a fungal sugar transporter family
title_fullStr Stepwise functional evolution in a fungal sugar transporter family
title_full_unstemmed Stepwise functional evolution in a fungal sugar transporter family
title_sort Stepwise functional evolution in a fungal sugar transporter family
author Gonçalves, Carla
author_facet Gonçalves, Carla
Coelho, Mauro A.
Salema-Oom, Madalena
Gonçalves, Paula
author_role author
author2 Coelho, Mauro A.
Salema-Oom, Madalena
Gonçalves, Paula
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Gonçalves, Carla
Coelho, Mauro A.
Salema-Oom, Madalena
Gonçalves, Paula
dc.subject.por.fl_str_mv Fructose transport
Yeast metabolic evolution
Horizontal gene transfer
Ffz
DHA1
topic Fructose transport
Yeast metabolic evolution
Horizontal gene transfer
Ffz
DHA1
description This is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record Mol Biol Evol (2016) 33 (2): 352-366 is available online at: http://mbe.oxfordjournals.org/content/33/2/352 DOI 10.1093/molbev/msv220.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01T00:00:00Z
2016-02-01T00:00:00Z
2017-03-01T01:30:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/17556
url http://hdl.handle.net/10400.26/17556
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carla Gonçalves, Marco A. Coelho, Madalena Salema-Oom, and Paula Gonçalves. Stepwise Functional Evolution in a Fungal Sugar Transporter Family. Mol Biol Evol (2016) 33 (2): 352-366 first published online October 15, 2015. doi:10.1093/molbev/msv220
1537-1719
10.1093/molbev/msv220
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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