Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration

Detalhes bibliográficos
Autor(a) principal: Duarte, Rui M.
Data de Publicação: 2018
Outros Autores: Correia-Pinto, Jorge, Reis, R. L., Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58131
Resumo: Accepted manuscript
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spelling Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regenerationPolycaprolactoneCarbon dioxideSubcriticalBone regenerationScaffoldsBioactive agentsCiências Médicas::Medicina BásicaScience & TechnologyAccepted manuscriptThe preparation of three-dimensional polycaprolactone scaffolds using dense CO2 as foaming agent, without supercritical conditions, was evaluated in this study towards future applications in bone repair. Herein, 3D foams were obtained at 5.0 MPa and 45 °C. To induce bioactivity, β-tricalcium phosphate (β-TCP, 10 wt%) and dexamethasone (5 and 10 wt%) were dispersed in the scaffolds. Foams revealed a pore size range of 164–882 μm, 73–99% porosity and 79–99% interconnectivity, assessed by micro-computed tomography, and a Young modulus of 1.76–2.92 MPa. Dexamethasone did not impair morphology of the matrices in comparison with PCL+β-TCP, which presented a water uptake of nearly 100% after 14 days. A sustained release of dexamethasone was achieved over 35 days in physiologic solution. This study reports the feasibility of using dense CO2 to produce in one-step a porous matrix loaded with active agents opening new possibilities towards injectable systems for in situ foamingEuropean Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number REGPOT-CT2012-316331-POLARIS. It was also funded by the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” (RL1-ABMR-NORTE-01-0124-FEDER-000016) co-financed by North Portugal Regional Operational Programme (ON.2 – O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF) and the project NORTE‐01‐0145‐FEDER‐000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement. The authors would like to acknowledge the funding of the project Associate Laboratory ICVS/3B’s, under grant agreement number POCI-01-0145-FEDER-007038 supported by FEDER, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT)info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoDuarte, Rui M.Correia-Pinto, JorgeReis, R. L.Duarte, Ana Rita C.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58131engDuarte, R. M., Correia-Pinto, J., Reis, R. L., & Duarte, A. R. C. (2018). Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration. The Journal of Supercritical Fluids, 140, 1-100896-844610.1016/j.supflu.2018.05.019https://www.sciencedirect.com/science/article/pii/S0896844617308768info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:43Zoai:repositorium.sdum.uminho.pt:1822/58131Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:11.976912Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
title Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
spellingShingle Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
Duarte, Rui M.
Polycaprolactone
Carbon dioxide
Subcritical
Bone regeneration
Scaffolds
Bioactive agents
Ciências Médicas::Medicina Básica
Science & Technology
title_short Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
title_full Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
title_fullStr Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
title_full_unstemmed Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
title_sort Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration
author Duarte, Rui M.
author_facet Duarte, Rui M.
Correia-Pinto, Jorge
Reis, R. L.
Duarte, Ana Rita C.
author_role author
author2 Correia-Pinto, Jorge
Reis, R. L.
Duarte, Ana Rita C.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Duarte, Rui M.
Correia-Pinto, Jorge
Reis, R. L.
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Polycaprolactone
Carbon dioxide
Subcritical
Bone regeneration
Scaffolds
Bioactive agents
Ciências Médicas::Medicina Básica
Science & Technology
topic Polycaprolactone
Carbon dioxide
Subcritical
Bone regeneration
Scaffolds
Bioactive agents
Ciências Médicas::Medicina Básica
Science & Technology
description Accepted manuscript
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58131
url http://hdl.handle.net/1822/58131
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Duarte, R. M., Correia-Pinto, J., Reis, R. L., & Duarte, A. R. C. (2018). Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration. The Journal of Supercritical Fluids, 140, 1-10
0896-8446
10.1016/j.supflu.2018.05.019
https://www.sciencedirect.com/science/article/pii/S0896844617308768
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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