The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/23565 |
Resumo: | The authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009). |
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The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditionsantihypertensive drugsCHRONIC EPISODIC HYPOXIASYSTEMIC BLOOD-PRESSURECAROTID BARORECEPTOR STIMULATIONPULMONARY ARTERIAL-HYPERTENSIONRENAL SYMPATHETIC DENERVATIONRANDOMIZED CLINICAL-TRIALOBSTRUCTIVE SLEEP-APNEAPOSITIVE AIRWAY PRESSUREobstructive sleep apneaRESISTANT HYPERTENSIONhypertensionblood pressurechronic intermittent hypoxiaRENIN-ANGIOTENSIN SYSTEMantihypertensive drugsblood pressurechronic intermittent hypoxiahypertensionobstructive sleep apneaQP PhysiologyThe authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009).Sleep apnea/hypopnea disorders include centrally originated diseases and obstructive sleep apnea (OSA). This last condition is renowned as a frequent secondary cause of hypertension (HT). The mechanisms involved in the pathogenesis of HT can be summarized in relation to two main pathways: sympathetic nervous system stimulation mediated mainly by activation of carotid body (CB) chemoreflexes and/or asphyxia, and, by no means the least important, the systemic effects of chronic intermittent hypoxia (CIH). The use of animal models has revealed that CIH is the critical stimulus underlying sympathetic activity and hypertension, and that this effect requires the presence of functional arterial chemoreceptors, which are hyperactive in CIH. These models of CIH mimic the HT observed in humans and allow the study of CIH independently without the mechanical obstruction component. The effect of continuous positive airway pressure (CRAP), the gold standard treatment for OSA patients, to reduce blood pressure seems to be modest and concomitant antihypertensive therapy is still required. We focus this review on the efficacy of pharmacological interventions to revert HT associated with CIH conditions in both animal models and humans. First, we explore the experimental animal models, developed to mimic HT related to CIH, which have been used to investigate the effect of antihypertensive drugs (AHDs). Second, we review what is known about drug efficacy to reverse HT induced by CIH in animals. Moreover, findings in humans with OSA are cited to demonstrate the lack of strong evidence for the establishment of a first-line antihypertensive regimen for these patients. Indeed, specific therapeutic guidelines for the pharmacological treatment of HT in these patients are still lacking. Finally, we discuss the future perspectives concerning the non-pharmacological and pharmacological management of this particular type of HT.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNDiogo, LNMonteiro, Emília C.2017-09-25T22:01:14Z2014-092014-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article24application/pdfhttp://hdl.handle.net/10362/23565eng1664-042XPURE: 319554https://doi.org/10.3389/fphys.2014.00361info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:11:51Zoai:run.unl.pt:10362/23565Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:50.331778Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
title |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
spellingShingle |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions Diogo, LN antihypertensive drugs CHRONIC EPISODIC HYPOXIA SYSTEMIC BLOOD-PRESSURE CAROTID BARORECEPTOR STIMULATION PULMONARY ARTERIAL-HYPERTENSION RENAL SYMPATHETIC DENERVATION RANDOMIZED CLINICAL-TRIAL OBSTRUCTIVE SLEEP-APNEA POSITIVE AIRWAY PRESSURE obstructive sleep apnea RESISTANT HYPERTENSION hypertension blood pressure chronic intermittent hypoxia RENIN-ANGIOTENSIN SYSTEM antihypertensive drugs blood pressure chronic intermittent hypoxia hypertension obstructive sleep apnea QP Physiology |
title_short |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
title_full |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
title_fullStr |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
title_full_unstemmed |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
title_sort |
The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions |
author |
Diogo, LN |
author_facet |
Diogo, LN Monteiro, Emília C. |
author_role |
author |
author2 |
Monteiro, Emília C. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Diogo, LN Monteiro, Emília C. |
dc.subject.por.fl_str_mv |
antihypertensive drugs CHRONIC EPISODIC HYPOXIA SYSTEMIC BLOOD-PRESSURE CAROTID BARORECEPTOR STIMULATION PULMONARY ARTERIAL-HYPERTENSION RENAL SYMPATHETIC DENERVATION RANDOMIZED CLINICAL-TRIAL OBSTRUCTIVE SLEEP-APNEA POSITIVE AIRWAY PRESSURE obstructive sleep apnea RESISTANT HYPERTENSION hypertension blood pressure chronic intermittent hypoxia RENIN-ANGIOTENSIN SYSTEM antihypertensive drugs blood pressure chronic intermittent hypoxia hypertension obstructive sleep apnea QP Physiology |
topic |
antihypertensive drugs CHRONIC EPISODIC HYPOXIA SYSTEMIC BLOOD-PRESSURE CAROTID BARORECEPTOR STIMULATION PULMONARY ARTERIAL-HYPERTENSION RENAL SYMPATHETIC DENERVATION RANDOMIZED CLINICAL-TRIAL OBSTRUCTIVE SLEEP-APNEA POSITIVE AIRWAY PRESSURE obstructive sleep apnea RESISTANT HYPERTENSION hypertension blood pressure chronic intermittent hypoxia RENIN-ANGIOTENSIN SYSTEM antihypertensive drugs blood pressure chronic intermittent hypoxia hypertension obstructive sleep apnea QP Physiology |
description |
The authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009). |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09 2014-09-01T00:00:00Z 2017-09-25T22:01:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/23565 |
url |
http://hdl.handle.net/10362/23565 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-042X PURE: 319554 https://doi.org/10.3389/fphys.2014.00361 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
24 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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