Carotid body, insulin, and metabolic diseases: unraveling the links

Detalhes bibliográficos
Autor(a) principal: Conde, Silvia
Data de Publicação: 2014
Outros Autores: Sacramento, Joana, Guarino, MP, Gonzalez, Constancio, Obeso, Ana, Diogo, Lucília, Monteiro, Emília, Ribeiro, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/23493
Resumo: This work was supported by the Portuguese Foundation for Science and Technology [Grants EXPL/NEU-SCC/2183/2013] and by the L'Oreal/FCT/UNESCO Medals of Honor for Women in Science 2009 (to Silvia V. Conde) and by Spanish Ministry of Economy and Competitiveness [Grant BFU2012-37459 to Constancio Gonzalez] and by Spanish Ministry of Health-Institute Carlos III [CIBERES to Constancio Gonzalez].
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spelling Carotid body, insulin, and metabolic diseases: unraveling the linksCHRONIC CAFFEINE INTAKELOW-GLUCOSEHEART HEALTHcarotid bodyOBESITY-RELATED HYPERTENSIONSYMPATHETIC-NERVOUS-SYSTEMTYPE-2 DIABETES-MELLITUSCHRONIC INTERMITTENT HYPOXIAinsulin resistanceOBSTRUCTIVE SLEEP-APNEAPOSITIVE AIRWAY PRESSUREobstructive sleep apneaBLOOD-PRESSUREchronic intermittent hypoxiametabolic dysfunctioncarotid bodychronic intermittent hypoxiainsulin resistancemetabolic dysfunctionobstructive sleep apneaQP PhysiologyPhysiology (medical)SDG 3 - Good Health and Well-beingThis work was supported by the Portuguese Foundation for Science and Technology [Grants EXPL/NEU-SCC/2183/2013] and by the L'Oreal/FCT/UNESCO Medals of Honor for Women in Science 2009 (to Silvia V. Conde) and by Spanish Ministry of Economy and Competitiveness [Grant BFU2012-37459 to Constancio Gonzalez] and by Spanish Ministry of Health-Institute Carlos III [CIBERES to Constancio Gonzalez].The carotid bodies (CB) are peripheral chemoreceptors that sense changes in arterial blood O-2, CO2, and pH levels. Hypoxia, hypercapnia, and acidosis activate the CB, which respond by increasing the action potential frequency in their sensory nerve, the carotid sinus nerve (CSN). CSN activity is integrated in the brain stem to induce a panoply of cardiorespiratory reflexes aimed, primarily, to normalize the altered blood gases, via hyperventilation, and to regulate blood pressure and cardiac performance, via sympathetic nervous system (SNS) activation. Besides its role in the cardiorespiratory control the CB has been proposed as a metabolic sensor implicated in the control of energy homeostasis and, more recently, in the regulation of whole body insulin sensitivity. Hypercaloric diets cause CB overactivation in rats, which seems to be at the origin of the development of insulin resistance and hypertension, core features of metabolic syndrome and type 2 diabetes. Consistent with this notion, CB sensory denervation prevents metabolic and hemodynamic alterations in hypercaloric feed animal. Obstructive sleep apnea (OSA) is another chronic disorder characterized by increased CB activity and intimately related with several metabolic and cardiovascular abnormalities. In this manuscript we review in a concise manner the putative pathways linking CB chemoreceptors deregulation with the pathogenesis of insulin resistance and arterial hypertension. Also, the link between chronic intermittent hypoxia (CIH) and insulin resistance is discussed. Then, a final section is devoted to debate strategies to reduce CB activity and its use for prevention and therapeutics of metabolic diseases with an emphasis on new exciting research in the modulation of bioelectronic signals, likely to be central in the future.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNConde, SilviaSacramento, JoanaGuarino, MPGonzalez, ConstancioObeso, AnaDiogo, LucíliaMonteiro, EmíliaRibeiro, Maria João2017-09-21T22:00:50Z2014-10-292014-10-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/23493eng1664-042XPURE: 319814https://doi.org/10.3389/fphys.2014.00418info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:11:46Zoai:run.unl.pt:10362/23493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:49.316928Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Carotid body, insulin, and metabolic diseases: unraveling the links
title Carotid body, insulin, and metabolic diseases: unraveling the links
spellingShingle Carotid body, insulin, and metabolic diseases: unraveling the links
Conde, Silvia
CHRONIC CAFFEINE INTAKE
LOW-GLUCOSE
HEART HEALTH
carotid body
OBESITY-RELATED HYPERTENSION
SYMPATHETIC-NERVOUS-SYSTEM
TYPE-2 DIABETES-MELLITUS
CHRONIC INTERMITTENT HYPOXIA
insulin resistance
OBSTRUCTIVE SLEEP-APNEA
POSITIVE AIRWAY PRESSURE
obstructive sleep apnea
BLOOD-PRESSURE
chronic intermittent hypoxia
metabolic dysfunction
carotid body
chronic intermittent hypoxia
insulin resistance
metabolic dysfunction
obstructive sleep apnea
QP Physiology
Physiology (medical)
SDG 3 - Good Health and Well-being
title_short Carotid body, insulin, and metabolic diseases: unraveling the links
title_full Carotid body, insulin, and metabolic diseases: unraveling the links
title_fullStr Carotid body, insulin, and metabolic diseases: unraveling the links
title_full_unstemmed Carotid body, insulin, and metabolic diseases: unraveling the links
title_sort Carotid body, insulin, and metabolic diseases: unraveling the links
author Conde, Silvia
author_facet Conde, Silvia
Sacramento, Joana
Guarino, MP
Gonzalez, Constancio
Obeso, Ana
Diogo, Lucília
Monteiro, Emília
Ribeiro, Maria João
author_role author
author2 Sacramento, Joana
Guarino, MP
Gonzalez, Constancio
Obeso, Ana
Diogo, Lucília
Monteiro, Emília
Ribeiro, Maria João
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Conde, Silvia
Sacramento, Joana
Guarino, MP
Gonzalez, Constancio
Obeso, Ana
Diogo, Lucília
Monteiro, Emília
Ribeiro, Maria João
dc.subject.por.fl_str_mv CHRONIC CAFFEINE INTAKE
LOW-GLUCOSE
HEART HEALTH
carotid body
OBESITY-RELATED HYPERTENSION
SYMPATHETIC-NERVOUS-SYSTEM
TYPE-2 DIABETES-MELLITUS
CHRONIC INTERMITTENT HYPOXIA
insulin resistance
OBSTRUCTIVE SLEEP-APNEA
POSITIVE AIRWAY PRESSURE
obstructive sleep apnea
BLOOD-PRESSURE
chronic intermittent hypoxia
metabolic dysfunction
carotid body
chronic intermittent hypoxia
insulin resistance
metabolic dysfunction
obstructive sleep apnea
QP Physiology
Physiology (medical)
SDG 3 - Good Health and Well-being
topic CHRONIC CAFFEINE INTAKE
LOW-GLUCOSE
HEART HEALTH
carotid body
OBESITY-RELATED HYPERTENSION
SYMPATHETIC-NERVOUS-SYSTEM
TYPE-2 DIABETES-MELLITUS
CHRONIC INTERMITTENT HYPOXIA
insulin resistance
OBSTRUCTIVE SLEEP-APNEA
POSITIVE AIRWAY PRESSURE
obstructive sleep apnea
BLOOD-PRESSURE
chronic intermittent hypoxia
metabolic dysfunction
carotid body
chronic intermittent hypoxia
insulin resistance
metabolic dysfunction
obstructive sleep apnea
QP Physiology
Physiology (medical)
SDG 3 - Good Health and Well-being
description This work was supported by the Portuguese Foundation for Science and Technology [Grants EXPL/NEU-SCC/2183/2013] and by the L'Oreal/FCT/UNESCO Medals of Honor for Women in Science 2009 (to Silvia V. Conde) and by Spanish Ministry of Economy and Competitiveness [Grant BFU2012-37459 to Constancio Gonzalez] and by Spanish Ministry of Health-Institute Carlos III [CIBERES to Constancio Gonzalez].
publishDate 2014
dc.date.none.fl_str_mv 2014-10-29
2014-10-29T00:00:00Z
2017-09-21T22:00:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/23493
url http://hdl.handle.net/10362/23493
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-042X
PURE: 319814
https://doi.org/10.3389/fphys.2014.00418
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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