The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109442 https://doi.org/10.3390/genes5040926 |
Resumo: | Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing. |
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The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound HealingmicroRNAdiabetesmacrovascular and microvascular complicationsskinwound healinginflammationvascular diseasediagnostic biomarkerstherapeutic targetsOverweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing.MDPI2014-09-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109442http://hdl.handle.net/10316/109442https://doi.org/10.3390/genes5040926eng2073-4425Moura, JoãoBørsheim, ElisabetCarvalho, Eugeniainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-16T09:08:32Zoai:estudogeral.uc.pt:10316/109442Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:38.479682Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
title |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
spellingShingle |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing Moura, João microRNA diabetes macrovascular and microvascular complications skin wound healing inflammation vascular disease diagnostic biomarkers therapeutic targets |
title_short |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
title_full |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
title_fullStr |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
title_full_unstemmed |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
title_sort |
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing |
author |
Moura, João |
author_facet |
Moura, João Børsheim, Elisabet Carvalho, Eugenia |
author_role |
author |
author2 |
Børsheim, Elisabet Carvalho, Eugenia |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Moura, João Børsheim, Elisabet Carvalho, Eugenia |
dc.subject.por.fl_str_mv |
microRNA diabetes macrovascular and microvascular complications skin wound healing inflammation vascular disease diagnostic biomarkers therapeutic targets |
topic |
microRNA diabetes macrovascular and microvascular complications skin wound healing inflammation vascular disease diagnostic biomarkers therapeutic targets |
description |
Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109442 http://hdl.handle.net/10316/109442 https://doi.org/10.3390/genes5040926 |
url |
http://hdl.handle.net/10316/109442 https://doi.org/10.3390/genes5040926 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2073-4425 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134138729496576 |