Measurements in first-trimester abortion products a pathologic study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/70514 |
Resumo: | Context.-Related to the advances in prenatal diagnosis and the emergence of medically challenging situations, there has been an increased interest in conducting a pathologic study of first-trimester abortion products. Objective.-To evaluate measurements across a large group of first-trimester spontaneous abortion specimens. Potential goals include a validation of prenatal embryo and gestational-sac measurements as a function of gestational age (GA). Design.-A retrospective case study of first-trimester spontaneous abortions between June 2015 and April 2017 in Centro de Genética Clínica Embryo-Fetal Pathology Laboratory, Porto, Portugal. Considering the inclusion criteria, 585 complete gestational sacs, 182 embryos, and 116 umbilical cords were selected. We recorded the weight of the gestational sacs and embryos and measurements of gestational sacs, umbilical cords, and embryo crown-rump length. Models were computed using regression techniques. Results.-Gestational-sac diameter percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval the diameter increased an average of 3 mm. Umbilical cord length percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval, the length increased an average of 1.35 mm. Embryo crown-rump length estimated mean 6 SD values were GA 6 weeks, 5.3 6 2.3 mm; GA 7 weeks, 9.4 6 4.8 mm; GA 8 weeks, 13.7 6 8.2 mm; GA 9 weeks, 20.8 6 9.1 mm; GA 10 weeks, 22.6 6 13.4 mm; GA 11 weeks, 29.4 6 12.9 mm; and GA 12 weeks, 52 mm. Conclusions.-Pathologic measurements obtained should be compared to expected measurements and correlated with ultrasound findings, clinical information, and microscopic findings. Deviations from expected values could lead to an understanding of early pregnancy loss. |
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Measurements in first-trimester abortion products a pathologic studyScience & TechnologyContext.-Related to the advances in prenatal diagnosis and the emergence of medically challenging situations, there has been an increased interest in conducting a pathologic study of first-trimester abortion products. Objective.-To evaluate measurements across a large group of first-trimester spontaneous abortion specimens. Potential goals include a validation of prenatal embryo and gestational-sac measurements as a function of gestational age (GA). Design.-A retrospective case study of first-trimester spontaneous abortions between June 2015 and April 2017 in Centro de Genética Clínica Embryo-Fetal Pathology Laboratory, Porto, Portugal. Considering the inclusion criteria, 585 complete gestational sacs, 182 embryos, and 116 umbilical cords were selected. We recorded the weight of the gestational sacs and embryos and measurements of gestational sacs, umbilical cords, and embryo crown-rump length. Models were computed using regression techniques. Results.-Gestational-sac diameter percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval the diameter increased an average of 3 mm. Umbilical cord length percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval, the length increased an average of 1.35 mm. Embryo crown-rump length estimated mean 6 SD values were GA 6 weeks, 5.3 6 2.3 mm; GA 7 weeks, 9.4 6 4.8 mm; GA 8 weeks, 13.7 6 8.2 mm; GA 9 weeks, 20.8 6 9.1 mm; GA 10 weeks, 22.6 6 13.4 mm; GA 11 weeks, 29.4 6 12.9 mm; and GA 12 weeks, 52 mm. Conclusions.-Pathologic measurements obtained should be compared to expected measurements and correlated with ultrasound findings, clinical information, and microscopic findings. Deviations from expected values could lead to an understanding of early pregnancy loss.This work was developed under the scope of the project NORTE-01-0145-FEDER-000013, NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020) under the Portugal Partnership Agreement, through the European Regional Development Fund (FEDER), and through the Competitiveness Factors Operational Programme (COMPETE) and by national funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038 Centro de Genética Clínica, CGC Genetics, Porto Portugal. The authors have no relevant financial interest in the products or companies described in this article.College of American PathologistsUniversidade do MinhoCardoso, Rosete Maria Amorim Novais NogueiraSousa, SaraBraga, A. C.Azevedo, AnaPereira, NunoCarmo, OlímpiaTavares, Maria PurificaçãoCorreia-Pinto, Jorge20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/70514engRosete Nogueira, Sara Sousa, Ana Cristina Braga, Ana Azevedo, Nuno Pereira, Olímpia Carmo, Maria Purificação Tavares, Jorge Correia Pinto; Measurements in First-Trimester Abortion Products: A Pathologic Study. Arch Pathol Lab Med 1 February 2020; 144 (2): 207–214. doi: https://doi.org/10.5858/arpa.2018-0181-OA0003-998510.5858/arpa.2018-0181-OA31173530https://meridian.allenpress.com/aplm/article/144/2/207/433650/Measurements-in-First-Trimester-Abortion-Productsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:24Zoai:repositorium.sdum.uminho.pt:1822/70514Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:55.501499Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Measurements in first-trimester abortion products a pathologic study |
title |
Measurements in first-trimester abortion products a pathologic study |
spellingShingle |
Measurements in first-trimester abortion products a pathologic study Cardoso, Rosete Maria Amorim Novais Nogueira Science & Technology |
title_short |
Measurements in first-trimester abortion products a pathologic study |
title_full |
Measurements in first-trimester abortion products a pathologic study |
title_fullStr |
Measurements in first-trimester abortion products a pathologic study |
title_full_unstemmed |
Measurements in first-trimester abortion products a pathologic study |
title_sort |
Measurements in first-trimester abortion products a pathologic study |
author |
Cardoso, Rosete Maria Amorim Novais Nogueira |
author_facet |
Cardoso, Rosete Maria Amorim Novais Nogueira Sousa, Sara Braga, A. C. Azevedo, Ana Pereira, Nuno Carmo, Olímpia Tavares, Maria Purificação Correia-Pinto, Jorge |
author_role |
author |
author2 |
Sousa, Sara Braga, A. C. Azevedo, Ana Pereira, Nuno Carmo, Olímpia Tavares, Maria Purificação Correia-Pinto, Jorge |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cardoso, Rosete Maria Amorim Novais Nogueira Sousa, Sara Braga, A. C. Azevedo, Ana Pereira, Nuno Carmo, Olímpia Tavares, Maria Purificação Correia-Pinto, Jorge |
dc.subject.por.fl_str_mv |
Science & Technology |
topic |
Science & Technology |
description |
Context.-Related to the advances in prenatal diagnosis and the emergence of medically challenging situations, there has been an increased interest in conducting a pathologic study of first-trimester abortion products. Objective.-To evaluate measurements across a large group of first-trimester spontaneous abortion specimens. Potential goals include a validation of prenatal embryo and gestational-sac measurements as a function of gestational age (GA). Design.-A retrospective case study of first-trimester spontaneous abortions between June 2015 and April 2017 in Centro de Genética Clínica Embryo-Fetal Pathology Laboratory, Porto, Portugal. Considering the inclusion criteria, 585 complete gestational sacs, 182 embryos, and 116 umbilical cords were selected. We recorded the weight of the gestational sacs and embryos and measurements of gestational sacs, umbilical cords, and embryo crown-rump length. Models were computed using regression techniques. Results.-Gestational-sac diameter percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval the diameter increased an average of 3 mm. Umbilical cord length percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval, the length increased an average of 1.35 mm. Embryo crown-rump length estimated mean 6 SD values were GA 6 weeks, 5.3 6 2.3 mm; GA 7 weeks, 9.4 6 4.8 mm; GA 8 weeks, 13.7 6 8.2 mm; GA 9 weeks, 20.8 6 9.1 mm; GA 10 weeks, 22.6 6 13.4 mm; GA 11 weeks, 29.4 6 12.9 mm; and GA 12 weeks, 52 mm. Conclusions.-Pathologic measurements obtained should be compared to expected measurements and correlated with ultrasound findings, clinical information, and microscopic findings. Deviations from expected values could lead to an understanding of early pregnancy loss. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/70514 |
url |
http://hdl.handle.net/1822/70514 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rosete Nogueira, Sara Sousa, Ana Cristina Braga, Ana Azevedo, Nuno Pereira, Olímpia Carmo, Maria Purificação Tavares, Jorge Correia Pinto; Measurements in First-Trimester Abortion Products: A Pathologic Study. Arch Pathol Lab Med 1 February 2020; 144 (2): 207–214. doi: https://doi.org/10.5858/arpa.2018-0181-OA 0003-9985 10.5858/arpa.2018-0181-OA 31173530 https://meridian.allenpress.com/aplm/article/144/2/207/433650/Measurements-in-First-Trimester-Abortion-Products |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
College of American Pathologists |
publisher.none.fl_str_mv |
College of American Pathologists |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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