Abdominal perfusion pressure in critically ill cirrhotic patients

Detalhes bibliográficos
Autor(a) principal: Pereira, Rui Antunes
Data de Publicação: 2023
Outros Autores: Esteves, André F., Cardoso, Filipe S., Perdigoto, Rui, Marcelino, Paulo, Saliba, Faouzi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153629
Resumo: Funding Information: The authors of this study would like to thank the entire nursing and medical staff of the intensive care unit, Unidade de Cuidados Intensivos Polivalente 7, at Hospital de Curry Cabral, for their fundamental work in this study, and the “Centro de Investigação”, at Centro Hospitalar Universitário Lisboa Central, for their support. Publisher Copyright: © 2023, The Author(s).
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spelling Abdominal perfusion pressure in critically ill cirrhotic patientsa prospective observational studyGeneralFunding Information: The authors of this study would like to thank the entire nursing and medical staff of the intensive care unit, Unidade de Cuidados Intensivos Polivalente 7, at Hospital de Curry Cabral, for their fundamental work in this study, and the “Centro de Investigação”, at Centro Hospitalar Universitário Lisboa Central, for their support. Publisher Copyright: © 2023, The Author(s).In critical patients, abdominal perfusion pressure (APP) has been shown to correlate with outcome. However, data from cirrhotic patients is scarce. We aimed to characterize APP in critically ill cirrhotic patients, analyze the prevalence and risk factors of abdominal hypoperfusion (AhP) and outcomes. A prospective cohort study in a general ICU specialized in liver disease at a tertiary hospital center recruited consecutive cirrhotic patients between October 2016 and December 2021. The study included 101 patients, with a mean age of 57.2 (± 10.4) years and a female gender proportion of 23.5%. The most frequent etiology of cirrhosis was alcohol (51.0%), and the precipitant event was infection (37.3%). ACLF grade (1–3) distribution was 8.9%, 26.7% and 52.5%, respectively. A total of 1274 measurements presented a mean APP of 63 (± 15) mmHg. Baseline AhP prevalence was 47%, independently associated with paracentesis (aOR 4.81, CI 95% 1.46–15.8, p = 0.01) and ACLF grade (aOR 2.41, CI 95% 1.20–4.85, p = 0.01). Similarly, AhP during the first week (64%) had baseline ACLF grade (aOR 2.09, CI 95% 1.29–3.39, p = 0.003) as a risk factor. Independent risk factors for 28-day mortality were bilirubin (aOR 1.10, CI 95% 1.04–1.16, p < 0.001) and SAPS II score (aOR 1.07, CI 95% 1.03–1.11, p = 0.001). There was a high prevalence of AhP in critical cirrhotic patients. Abdominal hypoperfusion was independently associated with higher ACLF grade and baseline paracentesis. Risk factors for 28-day mortality included clinical severity and total bilirubin. The prevention and treatment of AhP in the high-risk cirrhotic patient is prudential.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPereira, Rui AntunesEsteves, André F.Cardoso, Filipe S.Perdigoto, RuiMarcelino, PauloSaliba, Faouzi2023-06-05T22:21:11Z2023-052023-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/153629eng2045-2322PURE: 62792367https://doi.org/10.1038/s41598-023-34367-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:11Zoai:run.unl.pt:10362/153629Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:21.177120Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Abdominal perfusion pressure in critically ill cirrhotic patients
a prospective observational study
title Abdominal perfusion pressure in critically ill cirrhotic patients
spellingShingle Abdominal perfusion pressure in critically ill cirrhotic patients
Pereira, Rui Antunes
General
title_short Abdominal perfusion pressure in critically ill cirrhotic patients
title_full Abdominal perfusion pressure in critically ill cirrhotic patients
title_fullStr Abdominal perfusion pressure in critically ill cirrhotic patients
title_full_unstemmed Abdominal perfusion pressure in critically ill cirrhotic patients
title_sort Abdominal perfusion pressure in critically ill cirrhotic patients
author Pereira, Rui Antunes
author_facet Pereira, Rui Antunes
Esteves, André F.
Cardoso, Filipe S.
Perdigoto, Rui
Marcelino, Paulo
Saliba, Faouzi
author_role author
author2 Esteves, André F.
Cardoso, Filipe S.
Perdigoto, Rui
Marcelino, Paulo
Saliba, Faouzi
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Pereira, Rui Antunes
Esteves, André F.
Cardoso, Filipe S.
Perdigoto, Rui
Marcelino, Paulo
Saliba, Faouzi
dc.subject.por.fl_str_mv General
topic General
description Funding Information: The authors of this study would like to thank the entire nursing and medical staff of the intensive care unit, Unidade de Cuidados Intensivos Polivalente 7, at Hospital de Curry Cabral, for their fundamental work in this study, and the “Centro de Investigação”, at Centro Hospitalar Universitário Lisboa Central, for their support. Publisher Copyright: © 2023, The Author(s).
publishDate 2023
dc.date.none.fl_str_mv 2023-06-05T22:21:11Z
2023-05
2023-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153629
url http://hdl.handle.net/10362/153629
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 62792367
https://doi.org/10.1038/s41598-023-34367-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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