Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/143 |
Resumo: | Serotonin (5-hydroxytryptamine [5-HT]) is known to influence a wide range of behaviors and physiological processes, but relatively little is known about events that trigger 5-HT release. To address this issue, we recorded from neurons in the dorsal raphe nucleus (DRN) in rats performing an odor-guided spatial decision task. A large fraction of DRN neurons showed transient firing time locked to behavioral events on timescales as little as 20 ms. DRN transients were sometimes correlated with reward parameters, but also encoded specific sensorimotor events, including stimulus identity and response direction. These behavioral correlates were diverse but showed no apparent relationship with waveform or other firing properties indicative of neurochemical identity. These results suggest that the 5-HT system does not encode a unitary signal and that it will broadcast specific information to the forebrain with speed and precision sufficient not only to modulate but also to dynamically sculpt ongoing information processing. |
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Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward eventsFREELY MOVING CATSJUXTACELLULAR LABELING METHODSSEROTONIN NEURONSOLFACTORY DISCRIMINATIONVISUAL-STIMULIUNIT-ACTIVITYSerotonin (5-hydroxytryptamine [5-HT]) is known to influence a wide range of behaviors and physiological processes, but relatively little is known about events that trigger 5-HT release. To address this issue, we recorded from neurons in the dorsal raphe nucleus (DRN) in rats performing an odor-guided spatial decision task. A large fraction of DRN neurons showed transient firing time locked to behavioral events on timescales as little as 20 ms. DRN transients were sometimes correlated with reward parameters, but also encoded specific sensorimotor events, including stimulus identity and response direction. These behavioral correlates were diverse but showed no apparent relationship with waveform or other firing properties indicative of neurochemical identity. These results suggest that the 5-HT system does not encode a unitary signal and that it will broadcast specific information to the forebrain with speed and precision sufficient not only to modulate but also to dynamically sculpt ongoing information processing.American Physiological Society'sARCARanade, SPMainen, ZF2010-08-05T09:37:22Z2009-112009-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/143engRanade, SP., Mainen, ZF.(2009). "Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor,and reward events”. Journal of Neurophysiology. 102 (5): 3026-30370022-3077info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:39Zoai:arca.igc.gulbenkian.pt:10400.7/143Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:35.572758Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
title |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
spellingShingle |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events Ranade, SP FREELY MOVING CATS JUXTACELLULAR LABELING METHODS SEROTONIN NEURONS OLFACTORY DISCRIMINATION VISUAL-STIMULI UNIT-ACTIVITY |
title_short |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
title_full |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
title_fullStr |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
title_full_unstemmed |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
title_sort |
Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events |
author |
Ranade, SP |
author_facet |
Ranade, SP Mainen, ZF |
author_role |
author |
author2 |
Mainen, ZF |
author2_role |
author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Ranade, SP Mainen, ZF |
dc.subject.por.fl_str_mv |
FREELY MOVING CATS JUXTACELLULAR LABELING METHODS SEROTONIN NEURONS OLFACTORY DISCRIMINATION VISUAL-STIMULI UNIT-ACTIVITY |
topic |
FREELY MOVING CATS JUXTACELLULAR LABELING METHODS SEROTONIN NEURONS OLFACTORY DISCRIMINATION VISUAL-STIMULI UNIT-ACTIVITY |
description |
Serotonin (5-hydroxytryptamine [5-HT]) is known to influence a wide range of behaviors and physiological processes, but relatively little is known about events that trigger 5-HT release. To address this issue, we recorded from neurons in the dorsal raphe nucleus (DRN) in rats performing an odor-guided spatial decision task. A large fraction of DRN neurons showed transient firing time locked to behavioral events on timescales as little as 20 ms. DRN transients were sometimes correlated with reward parameters, but also encoded specific sensorimotor events, including stimulus identity and response direction. These behavioral correlates were diverse but showed no apparent relationship with waveform or other firing properties indicative of neurochemical identity. These results suggest that the 5-HT system does not encode a unitary signal and that it will broadcast specific information to the forebrain with speed and precision sufficient not only to modulate but also to dynamically sculpt ongoing information processing. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-11 2009-11-01T00:00:00Z 2010-08-05T09:37:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/143 |
url |
http://hdl.handle.net/10400.7/143 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ranade, SP., Mainen, ZF.(2009). "Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor,and reward events”. Journal of Neurophysiology. 102 (5): 3026-3037 0022-3077 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Physiological Society's |
publisher.none.fl_str_mv |
American Physiological Society's |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130571451924480 |